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Immunology

D-Index
72
Citations
15730
World Ranking
2248
National Ranking
201

Overview

Jean Langhorne is affiliated with The Francis Crick Institute in the United Kingdom. Their research centers primarily on medicine and immunology and microbiology, with a focus on public health, environmental and occupational health; immunology; parasitology; hematology; and nutrition and dietetics.

Their major topics of work include malaria research and control, mosquito-borne diseases and control, invertebrate immune response mechanisms, complement system in diseases, T-cell and B-cell immunology, parasites and host interactions, and child nutrition and water access.

Langhorne has contributed extensively to scientific literature, with notable recent publications including:

  • "Distinct ontogenetic lineages dictate cDC2 heterogeneity" (2024, Nature Immunology)
  • "Manipulating niche composition limits damage to haematopoietic stem cells during Plasmodium infection" (2020, Nature Cell Biology)
  • "Acquisition of suppressive function by conventional T cells limits antitumor immunity upon T reg depletion" (2023, Science Immunology)
  • "Analysis of pir gene expression across the Plasmodium life cycle" (2021, Malaria Journal)
  • "10-year longitudinal study of malaria in children: Insights into acquisition and maintenance of naturally acquired immunity" (2021, Wellcome Open Research)

The venues where Langhorne frequently publishes include Wellcome Open Research, Malaria Journal, Current Research in Immunology, Nature Immunology, and Nature Cell Biology.

Frequent coauthors collaborating with Langhorne are Deirdre Cunningham, Adam J. Reid, John Addy, Philip Bejon, and Caroline Hosking.

Best Publications

  • Immunity to malaria: more questions than answers.

    Jean Langhorne;Francis M Ndungu;Anne-Marit Sponaas;Kevin Marsh

  • High sensitivity collisionally-activated decomposition tandem mass spectrometry on a novel quadrupole/orthogonal-acceleration time-of-flight mass spectrometer.

    Howard R. Morris;Thanai Paxton;Anne Dell;Jean Langhorne

  • The role of animal models for research on severe malaria.

    Alister G. Craig;Georges E. Grau;Chris Janse;James W. Kazura

  • A comprehensive evaluation of rodent malaria parasite genomes and gene expression

    Thomas D Otto;Ulrike Böhme;Andrew P Jackson;Martin Hunt

  • A Defect in Interleukin-10 Leads to Enhanced Malarial Disease in Plasmodium chabaudi chabaudi Infection in Mice

    Ching Li;Inés Corraliza;Jean Langhorne;Jean Langhorne

  • Malarial anemia: of mice and men.

    Abigail A. Lamikanra;Douglas Brown;Alexandre Potocnik;Climent Casals-Pascual;Climent Casals-Pascual

  • IL-27 Promotes IL-10 Production by Effector Th1 CD4+ T Cells: A Critical Mechanism for Protection from Severe Immunopathology during Malaria Infection

    Ana Paula Freitas do Rosário;Tracey Lamb;Tracey Lamb;Philip Spence;Robin Stephens

  • The role of the spleen in malaria.

    Hernando A. del Portillo;Mireia Ferrer;Thibaut Brugat;Lorena Martin-Jaular

  • Mouse models of blood-stage malaria infections: Immune responses and cytokines involved in protection and pathology

    Jean Langhorne;Stuart J Quin;Latifu A Sanni

  • Pathology of Plasmodium chabaudi chabaudi Infection and Mortality in Interleukin-10-Deficient Mice Are Ameliorated by Anti-Tumor Necrosis Factor Alpha and Exacerbated by Anti-Transforming Growth Factor β Antibodies

    Ching Li;Latifu A. Sanni;Fakhreldin Omer;Eleanor Riley

  • A role for B cells in the development of T cell helper function in a malaria infection in mice

    Jean Langhorne;Caroline Cross;Elsa Seixas;Ching Li

  • Frequencies of CD4+ T cells reactive with Plasmodium chabaudi chabaudi: distinct response kinetics for cells with Th1 and Th2 characteristics during infection

    Jean Langhorne;Sylvie Gillard;Birgit Simon;Sally Slade

  • CD4 T-Cell Subsets in Malaria: TH1/TH2 Revisited

    Damian Perez-Mazliah;Jean Langhorne

  • Gene-targeted mice lacking B cells are unable to eliminate a blood stage malaria infection.

    T von der Weid;N Honarvar;J Langhorne

  • Systemic lupus erythematosus-associated defects in the inhibitory receptor FcγRIIb reduce susceptibility to malaria

    Menna R. Clatworthy;Lisa Willcocks;Britta Urban;Jean Langhorne

  • Vector transmission regulates immune control of Plasmodium virulence

    Philip J. Spence;William Jarra;Prisca Lévy;Adam J. Reid

  • Malaria infection changes the ability of splenic dendritic cell populations to stimulate antigen-specific T cells.

    Anne-Marit Sponaas;Emma Tamsin Cadman;Cecile Voisine;Vicky Harrison

  • Production of Interferon-Gamma during Infection of Mice with Plasmodium chabaudi chabaudi

    Sally J. Slade;Jean Langhorne

  • Migrating monocytes recruited to the spleen play an important role in control of blood stage malaria

    Anne-Marit Sponaas;Ana Paula Freitas do Rosario;Cecile Voisine;Beatris Mastelic

  • Plasmodium chabaudi chabaudi Infection in Mice Induces Strong B Cell Responses and Striking But Temporary Changes in Splenic Cell Distribution

    Ariel H. Achtman;Mahmood Khan;Ian C. M. MacLennan;Jean Langhorne

Frequent Co-Authors

Kevin Marsh
Kevin Marsh University of Oxford
Anne O'Garra
Anne O'Garra The Francis Crick Institute
Britta C. Urban
Britta C. Urban Liverpool School of Tropical Medicine
Patrick E. Duffy
Patrick E. Duffy National Institute of Allergy and Infectious Diseases
Anthony A. Holder
Anthony A. Holder The Francis Crick Institute
Klaus Eichmann
Klaus Eichmann Max Planck Society
Peter R. Preiser
Peter R. Preiser Nanyang Technological University
Matthew Berriman
Matthew Berriman University of Glasgow
Chris I. Newbold
Chris I. Newbold Wellcome Sanger Institute
Mandy Sanders
Mandy Sanders Wellcome Sanger Institute

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