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Immunology

D-Index
55
Citations
9041
World Ranking
3828
National Ranking
150

Overview

Shuhji Seki is affiliated with the National Defense Medical College in Japan and works primarily in the fields of immunology and microbiology as well as medicine. Their research has a focus on immune response, inflammation, and immune cell function, with an emphasis on molecular biology and clinical biochemistry aspects.

Their published work covers topics including immune response and inflammation, immune cell function and interaction, immunotherapy and immune responses, immune cells in cancer, T-cell and B-cell immunology, phagocytosis and immune regulation, and advanced glycation end products research.

Frequent publication venues for Shuhji Seki include:

  • American Journal of Physiology-Renal Physiology
  • Kidney & Blood Pressure Research
  • International Journal of Molecular Sciences
  • PLoS ONE
  • Scientific Reports

Notable recent papers from their research portfolio include:

  • Effects of a CCR2 antagonist on macrophages and Toll-like receptor 9 expression in a mouse model of diabetic nephropathy, 2021, American Journal of Physiology-Renal Physiology
  • Effects of L-Carnitine Treatment on Kidney Mitochondria and Macrophages in Mice with Diabetic Nephropathy, 2022, Kidney & Blood Pressure Research
  • Infections, Reactions of Natural Killer T Cells and Natural Killer Cells, and Kidney Injury, 2022, International Journal of Molecular Sciences
  • Contrasting functional responses of resident Kupffer cells and recruited liver macrophages to irradiation and liver X receptor stimulation, 2021, PLoS ONE
  • Liver X receptors regulate natural killer T cell population and antitumor activity in the liver of mice, 2021, Scientific Reports

Collaborative efforts have involved frequent co-authors such as:

  • Hiroyuki Nakashima
  • Masahiro Nakashima
  • Manabu Kinoshita
  • Takuya Ishikiriyama
  • Seigo Ito

Shuhji Seki's research extensively investigates mechanisms by which immune cells influence kidney injury and disease progression, especially in diabetic nephropathy models. The work also explores macrophage activity and natural killer T cell responses, which are relevant to tissue inflammation and immune regulation.

Overall, their contributions span multiple aspects of immunology, focusing on cellular interactions, molecular pathways, and immunological responses related to kidney function and pathology.

Best Publications

  • The liver as a crucial organ in the first line of host defense: the roles of Kupffer cells, natural killer (NK) cells and NK1.1 Ag+ T cells in T helper 1 immune responses.

    Shuhji Seki;Yoshiko Habu;Toshihiko Kawamura;Kazuyoshi Takeda

  • Characterization of two F4/80-positive Kupffer cell subsets by their function and phenotype in mice

    Manabu Kinoshita;Takefumi Uchida;Atsushi Sato;Masahiro Nakashima

  • Mechanisms of the Antimetastatic Effect in the Liver and of the Hepatocyte Injury Induced by α-Galactosylceramide in Mice

    Ryusuke Nakagawa;Ikuko Nagafune;Yoshiko Tazunoki;Hiromi Ehara

  • Decrease of CD56+T cells and natural killer cells in cirrhotic livers with hepatitis C may be involved in their susceptibility to hepatocellular carcinoma

    Nobuaki Kawarabayashi;Shuhji Seki;Kazuo Hatsuse;Takashi Ohkawa

  • Combined spinal and general anesthesia attenuates liver metastasis by preserving TH1/TH2 cytokine balance.

    Hiroki Wada;Shuhji Seki;Tetsuya Takahashi;Nobuaki Kawarabayashi

  • Details of an isolation method for hepatic lymphocytes in mice

    Hisami Watanabe;Kazuo Ohtsuka;Motohiko Kimura;Yoshinori Ikarashi

  • Estrogen administration activates extrathymic T cell differentiation in the liver.

    R Okuyama;T Abo;S Seki;T Ohteki

  • Systematic characterization of human CD8+ T cells with natural killer cell markers in comparison with natural killer cells and normal CD8+ T cells

    Takashi Ohkawa;Shuhji Seki;Hiroshi Dobashi;Yuji Koike

  • Involvement of NK1+ T cells and their IFN-gamma production in the generalized Shwartzman reaction.

    Kouetsu Ogasawara;Kazuyoshi Takeda;Wataru Hashimoto;Masayuki Satoh

  • Mouse liver T cells: Their change with aging and in comparison with peripheral T cells

    A Tsukahara;S Seki;T Iiai;T Moroda

  • Characterization of cytokine and iNOS mRNA expression in situ during the course of experimental autoimmune myocarditis in rats.

    Yuji Okura;Tadashi Yamamoto;Shin Goto;Takayuki Inomata

  • Distinct development and functions of resident and recruited liver Kupffer cells/macrophages

    Masami Ikarashi;Hiroyuki Nakashima;Manabu Kinoshita;Atsushi Sato

  • Macrophage- and neutrophil- dominant arthritis in human IL-1α transgenic mice

    Yasuo Niki;Harumoto Yamada;Shuhji Seki;Toshiyuki Kikuchi

  • Neutrophil elastase, MIP-2, and TLR-4 expression during human and experimental sepsis.

    Hironori Tsujimoto;Satoshi Ono;Takashi Majima;Nobuaki Kawarabayashi

  • Induction of CD16+ CD56bright NK Cells with Antitumour Cytotoxicity not only from CD16− CD56bright NK Cells but also from CD16− CD56dim NK Cells

    E. Takahashi;N. Kuranaga;K. Satoh;Y. Habu

  • Recombinant Murine Interleukin-12 Facilitates Induction of Cardiac Myosin–Specific Type 1 Helper T Cells in Rats

    Yuji Okura;Kazuyoshi Takeda;Shigeru Honda;Haruo Hanawa

  • CD47 is an adverse prognostic factor and a therapeutic target in gastric cancer.

    Kazumichi Yoshida;Hironori Tsujimoto;Kouji Matsumura;Manabu Kinoshita

  • Superoxide produced by Kupffer cells is an essential effector in concanavalin A-induced hepatitis in mice.

    Hiroyuki Nakashima;Manabu Kinoshita;Masahiro Nakashima;Yoshiko Habu

  • Helicobacter pylori Augments Growth of Gastric Cancers via the Lipopolysaccharide-Toll-like Receptor 4 Pathway whereas Its Lipopolysaccharide Attenuates Antitumor Activities of Human Mononuclear Cells

    Kentaro Chochi;Takashi Ichikura;Manabu Kinoshita;Takashi Majima

  • Flagellin enhances NK cell proliferation and activation directly and through dendritic cell-NK cell interactions

    Hironori Tsujimoto;Takefumi Uchida;Philip A. Efron;Philip O. Scumpia

  • Activation of monocytes and endothelial cells depends on the severity of surgical stress.

    Suefumi Aosasa;Satoshi Ono;Hidetaka Mochizuki;Hironori Tsujimoto

Frequent Co-Authors

Hidetaka Mochizuki
Hidetaka Mochizuki National Defense Medical College
Toru Abo
Toru Abo Niigata University
Michael R. Hamblin
Michael R. Hamblin University of Johannesburg
Shinji Takeoka
Shinji Takeoka Waseda University
Makoto Makishima
Makoto Makishima Nihon University
Lyle L. Moldawer
Lyle L. Moldawer University of Florida
Kazuyoshi Takeda
Kazuyoshi Takeda Juntendo University
Makoto Handa
Makoto Handa Keio University
Hidenori Suzuki
Hidenori Suzuki Nippon Medical School
Shigeaki Nonoyama
Shigeaki Nonoyama National Defense Medical College

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