Makoto Handa

Overview

Best Publications

• The role of von Willebrand factor and fibrinogen in platelet aggregation under varying shear stress.

  Y Ikeda;M Handa;K Kawano;T Kamata

  844
  Citations

• The von Willebrand factor-binding domain of platelet membrane glycoprotein Ib. Characterization by monoclonal antibodies and partial amino acid sequence analysis of proteolytic fragments

  M Handa;K Titani;L Z Holland;J R Roberts

  330
  Citations

• Turbulence activates platelet biogenesis to enable clinical scale ex vivo production

  Yukitaka Ito;Sou Nakamura;Naoshi Sugimoto;Tomohiro Shigemori

  309
  Citations

• Thrombopoietin induces tyrosine phosphorylation of Stat3 and Stat5 in human blood platelets

  Yoshitaka Miyakawa;Atsushi Oda;Brian J. Druker;Hiroshi Miyazaki

  242
  Citations

• Transmembrane calcium influx associated with von Willebrand factor binding to GP Ib in the initiation of shear-induced platelet aggregation

  Yasuo Ikeda;Makoto Handa;Tetsuji Kamata;Koichi Kawano

  234
  Citations

• Soluble P-selectin is present in normal circulation and its plasma level is elevated in patients with thrombotic thrombocytopenic purpura and haemolytic uraemic syndrome.

  Masahiko Katayama;Makoto Handa;Yohko Araki;Hironobu Ambo

  194
  Citations

• Amino acid sequence of the von Willebrand factor-binding domain of platelet membrane glycoprotein Ib

  Koiti Titani;Koji Takio;Makoto Handa;Zaverio M. Ruggeri

  189
  Citations

• Alternatively spliced isoform of P-selectin is present in vivo as a soluble molecule.

  Norihisa Ishiwata;Koji Takio;Masahiko Katayama;Kiyoaki Watanabe

  178
  Citations

• Recombinant thrombopoietin induces rapid protein tyrosine phosphorylation of Janus kinase 2 and Shc in human blood platelets.

  Yoshitaka Miyakawa;Atsushi Oda;Brian J. Druker;Takashi Kato

  178
  Citations

• Functional interaction of STAT5 and nuclear receptor co‐repressor SMRT: implications in negative regulation of STAT5‐dependent transcription

  Hideaki Nakajima;Hideaki Nakajima;Hideaki Nakajima;Paul K. Brindle;Makoto Handa;James N. Ihle;James N. Ihle

  162
  Citations

• Platelet unresponsiveness to collagen: Involvement of glycoprotein Ia-IIa (α2β1 integrin) deficiency associated with a myeloproliferative disorder

  M Handa;K Watanabe;Y Kawai;T Kamata

  159
  Citations

• Thrombopoietin primes human platelet aggregation induced by shear stress and by multiple agonists.

  Atsushi Oda;Yoshitaka Miyakawa;Brian J. Druker;Katsutoshi Ozaki

  158
  Citations

• Phosphatidylinositol 3-Kinase Is Involved in the Protection of Primary Cultured Human Erythroid Precursor Cells From Apoptosis

  Yoshihito Haseyama;Ken Ichi Sawada;Atsushi Oda;Kazuki Koizumi

  151
  Citations

• Soluble form of P-selectin in plasma is elevated in acute lung injury.

  F Sakamaki;A Ishizaka;M Handa;S Fujishima

  150
  Citations

• Association between diabetic retinopathy and genetic variations in α2β1 integrin, a platelet receptor for collagen

  Yumiko Matsubara;Mitsuru Murata;Taro Maruyama;Makoto Handa

  139
  Citations

• Hemodynamic forces modulate the effects of cytokines on fibrinolytic activity of endothelial cells

  Yohko Kawai;Yutaka Matsumoto;Kiyoaki Watanabe;Hiroshi Yamamoto

  132
  Citations

• Different effects of various anti-GPIIb-IIIa agents on shear-induced platelet activation and expression of procoagulant activity.

  S. Goto;N. Tamura;M. Li;M. Handa

  129
  Citations

• Functional phenotype of phosphoinositide 3-kinase p85α-null platelets characterized by an impaired response to GP VI stimulation

  Naohide Watanabe;Hideaki Nakajima;Hidenori Suzuki;Atsushi Oda

  126
  Citations

• Rapid tyrosine phosphorylation and activation of Bruton's tyrosine/Tec kinases in platelets induced by collagen binding or CD32 cross-linking.

  Atsushi Oda;Yasuo Ikeda;Hans D. Ochs;Brian J. Druker

  126
  Citations

• Shear-induced platelet aggregation in cerebral ischemia.

  Shinichiro Uchiyama;Masako Yamazaki;Shoichi Maruyama;Makoto Handa

  126
  Citations