What is he best known for?
The fields of study he is best known for:
- Gene
- Internal medicine
- Enzyme
Makoto Handa mainly focuses on Platelet, Biochemistry, Internal medicine, Molecular biology and Receptor tyrosine kinase.
His study in Platelet is interdisciplinary in nature, drawing from both Anesthesia, Biophysics and In vivo.
His research investigates the connection between Biochemistry and topics such as Von Willebrand factor that intersect with issues in Monoclonal antibody and Receptor.
His work focuses on many connections between Internal medicine and other disciplines, such as Endocrinology, that overlap with his field of interest in Glycoprotein, Umbilical vein, Interleukin and Tissue plasminogen activator.
His study explores the link between Molecular biology and topics such as Kinase activity that cross with problems in MAP kinase kinase kinase and Platelet-derived growth factor receptor.
His Receptor tyrosine kinase research integrates issues from Protein tyrosine phosphatase, Tyrosine kinase, LYN, Proto-oncogene tyrosine-protein kinase Src and Tyrosine phosphorylation.
His most cited work include:
- The role of von Willebrand factor and fibrinogen in platelet aggregation under varying shear stress. (536 citations)
- The von Willebrand factor-binding domain of platelet membrane glycoprotein Ib. Characterization by monoclonal antibodies and partial amino acid sequence analysis of proteolytic fragments (212 citations)
- Transmembrane calcium influx associated with von Willebrand factor binding to GP Ib in the initiation of shear-induced platelet aggregation (153 citations)
What are the main themes of his work throughout his whole career to date?
Makoto Handa spends much of his time researching Platelet, Biochemistry, Molecular biology, Platelet membrane glycoprotein and Biophysics.
The Platelet study combines topics in areas such as Fibrinogen and Liposome.
His Biochemistry research includes elements of Adenosine diphosphate and Cell biology.
His Molecular biology research is multidisciplinary, relying on both Mutation and Receptor, Integrin, Phosphorylation, Tyrosine phosphorylation.
His Platelet membrane glycoprotein study incorporates themes from Thrombasthenia and Recombinant DNA.
His work deals with themes such as Gastroenterology, Endocrinology and Immunology, which intersect with Internal medicine.
He most often published in these fields:
- Platelet (51.04%)
- Biochemistry (23.96%)
- Molecular biology (28.13%)
What were the highlights of his more recent work (between 2007-2021)?
- Platelet (51.04%)
- Biochemistry (23.96%)
- Liposome (7.81%)
In recent papers he was focusing on the following fields of study:
Platelet, Biochemistry, Liposome, Fibrinogen and Immunology are his primary areas of study.
His Platelet research incorporates themes from Spleen, Hemostasis, Thrombus, Pharmacology and In vivo.
Makoto Handa focuses mostly in the field of Biochemistry, narrowing it down to topics relating to Adenosine diphosphate and, in certain cases, Pharmacokinetics.
In his study, Biophysics and Peptide is inextricably linked to Platelet activation, which falls within the broad field of Liposome.
The study incorporates disciplines such as Hematopoietic stem cell transplantation, Internal medicine and Transplantation in addition to Immunology.
His research in Monoclonal antibody tackles topics such as Plasma protein binding which are related to areas like Molecular biology.
Between 2007 and 2021, his most popular works were:
- Turbulence activates platelet biogenesis to enable clinical scale ex vivo production (106 citations)
- Development of fibrinogen γ-chain peptide-coated, adenosine diphosphate-encapsulated liposomes as a synthetic platelet substitute (51 citations)
- Incidence of Transfusion-Related Adverse Reactions per Patient Reflects the Potential Risk of Transfusion Therapy in Japan (36 citations)
In his most recent research, the most cited papers focused on:
- Gene
- Internal medicine
- Enzyme
His primary areas of investigation include Platelet, Fibrinogen, Liposome, Biochemistry and Adenosine diphosphate.
Makoto Handa performs multidisciplinary study on Platelet and Allergic reaction in his works.
His study in Fibrinogen is interdisciplinary in nature, drawing from both Liver injury, Kidney and Thrombus.
His study focuses on the intersection of Liver injury and fields such as Anesthesia with connections in the field of Internal medicine.
His studies in Liposome integrate themes in fields like Platelet activation and Pharmacology.
His work in Biochemistry addresses subjects such as Pharmacokinetics, which are connected to disciplines such as Metabolite, Cholesterol, Immunoglobulin M, PEGylation and Complement system.
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