Makoto Handa mainly focuses on Platelet, Biochemistry, Internal medicine, Molecular biology and Receptor tyrosine kinase. His study in Platelet is interdisciplinary in nature, drawing from both Anesthesia, Biophysics and In vivo. His research investigates the connection between Biochemistry and topics such as Von Willebrand factor that intersect with issues in Monoclonal antibody and Receptor.
His work focuses on many connections between Internal medicine and other disciplines, such as Endocrinology, that overlap with his field of interest in Glycoprotein, Umbilical vein, Interleukin and Tissue plasminogen activator. His study explores the link between Molecular biology and topics such as Kinase activity that cross with problems in MAP kinase kinase kinase and Platelet-derived growth factor receptor. His Receptor tyrosine kinase research integrates issues from Protein tyrosine phosphatase, Tyrosine kinase, LYN, Proto-oncogene tyrosine-protein kinase Src and Tyrosine phosphorylation.
Makoto Handa spends much of his time researching Platelet, Biochemistry, Molecular biology, Platelet membrane glycoprotein and Biophysics. The Platelet study combines topics in areas such as Fibrinogen and Liposome. His Biochemistry research includes elements of Adenosine diphosphate and Cell biology.
His Molecular biology research is multidisciplinary, relying on both Mutation and Receptor, Integrin, Phosphorylation, Tyrosine phosphorylation. His Platelet membrane glycoprotein study incorporates themes from Thrombasthenia and Recombinant DNA. His work deals with themes such as Gastroenterology, Endocrinology and Immunology, which intersect with Internal medicine.
Platelet, Biochemistry, Liposome, Fibrinogen and Immunology are his primary areas of study. His Platelet research incorporates themes from Spleen, Hemostasis, Thrombus, Pharmacology and In vivo. Makoto Handa focuses mostly in the field of Biochemistry, narrowing it down to topics relating to Adenosine diphosphate and, in certain cases, Pharmacokinetics.
In his study, Biophysics and Peptide is inextricably linked to Platelet activation, which falls within the broad field of Liposome. The study incorporates disciplines such as Hematopoietic stem cell transplantation, Internal medicine and Transplantation in addition to Immunology. His research in Monoclonal antibody tackles topics such as Plasma protein binding which are related to areas like Molecular biology.
His primary areas of investigation include Platelet, Fibrinogen, Liposome, Biochemistry and Adenosine diphosphate. Makoto Handa performs multidisciplinary study on Platelet and Allergic reaction in his works. His study in Fibrinogen is interdisciplinary in nature, drawing from both Liver injury, Kidney and Thrombus.
His study focuses on the intersection of Liver injury and fields such as Anesthesia with connections in the field of Internal medicine. His studies in Liposome integrate themes in fields like Platelet activation and Pharmacology. His work in Biochemistry addresses subjects such as Pharmacokinetics, which are connected to disciplines such as Metabolite, Cholesterol, Immunoglobulin M, PEGylation and Complement system.
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The role of von Willebrand factor and fibrinogen in platelet aggregation under varying shear stress.
Y Ikeda;M Handa;K Kawano;T Kamata.
Journal of Clinical Investigation (1991)
The von Willebrand factor-binding domain of platelet membrane glycoprotein Ib. Characterization by monoclonal antibodies and partial amino acid sequence analysis of proteolytic fragments
M Handa;K Titani;L Z Holland;J R Roberts.
Journal of Biological Chemistry (1986)
Transmembrane calcium influx associated with von Willebrand factor binding to GP Ib in the initiation of shear-induced platelet aggregation
Yasuo Ikeda;Makoto Handa;Tetsuji Kamata;Koichi Kawano.
Thrombosis and Haemostasis (1993)
Thrombopoietin induces tyrosine phosphorylation of Stat3 and Stat5 in human blood platelets
Yoshitaka Miyakawa;Atsushi Oda;Brian J. Druker;Hiroshi Miyazaki.
Soluble P-selectin is present in normal circulation and its plasma level is elevated in patients with thrombotic thrombocytopenic purpura and haemolytic uraemic syndrome.
Masahiko Katayama;Makoto Handa;Yohko Araki;Hironobu Ambo.
British Journal of Haematology (1993)
Turbulence activates platelet biogenesis to enable clinical scale ex vivo production
Yukitaka Ito;Sou Nakamura;Naoshi Sugimoto;Tomohiro Shigemori.
Amino acid sequence of the von Willebrand factor-binding domain of platelet membrane glycoprotein Ib
Koiti Titani;Koji Takio;Makoto Handa;Zaverio M. Ruggeri.
Proceedings of the National Academy of Sciences of the United States of America (1987)
Alternatively spliced isoform of P-selectin is present in vivo as a soluble molecule.
Norihisa Ishiwata;Koji Takio;Masahiko Katayama;Kiyoaki Watanabe.
Journal of Biological Chemistry (1994)
Recombinant thrombopoietin induces rapid protein tyrosine phosphorylation of Janus kinase 2 and Shc in human blood platelets.
Yoshitaka Miyakawa;Atsushi Oda;Brian J. Druker;Takashi Kato.
Functional interaction of STAT5 and nuclear receptor co‐repressor SMRT: implications in negative regulation of STAT5‐dependent transcription
Hideaki Nakajima;Hideaki Nakajima;Hideaki Nakajima;Paul K. Brindle;Makoto Handa;James N. Ihle;James N. Ihle.
The EMBO Journal (2001)
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