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Biology and Biochemistry

D-Index
75
Citations
54167
World Ranking
5179
National Ranking
395

Overview

Ultan McDermott is a researcher affiliated with AstraZeneca in the United Kingdom, focusing primarily on the fields of Biochemistry, Genetics and Molecular Biology as well as Medicine. Their work spans molecular biology, cancer research, oncology, genetics, and computational theory and mathematics.

Their research concentrates on the following main topics:

  • Cancer Genomics and Diagnostics
  • Computational Drug Discovery Methods
  • Colorectal Cancer Treatments and Studies
  • CRISPR and Genetic Engineering
  • Lung Cancer Treatments and Mutations
  • Radiomics and Machine Learning in Medical Imaging
  • Protein Degradation and Inhibitors

McDermott has published extensively in venues including Cancer Research, bioRxiv (Cold Spring Harbor Laboratory), Science Translational Medicine, Nature Communications, and Communications Biology.

Frequent co-authors collaborating with McDermott include:

  • Matthias Pfeifer (9 publications)
  • Mathew J. Garnett (8 publications)
  • Aikaterini Chatzipli (7 publications)
  • Stacey Price (7 publications)
  • Enric Domingo (6 publications)

Some notable recent research papers authored or co-authored by McDermott are:

  • "Image-based consensus molecular subtype (imCMS) classification of colorectal cancer using deep learning", 2020, Gut
  • "ctDNA monitoring using patient-specific sequencing and integration of variant reads", 2020, Science Translational Medicine
  • "A YAP/FOXM1 axis mediates EMT-associated EGFR inhibitor resistance and increased expression of spindle assembly checkpoint components", 2020, Science Translational Medicine
  • "Knowledge graph-based recommendation framework identifies drivers of resistance in EGFR mutant non-small cell lung cancer", 2022, Nature Communications
  • "Genome-wide CRISPR screens of oral squamous cell carcinoma reveal fitness genes in the Hippo pathway", 2020, eLife

Best Publications

  • Signatures of mutational processes in human cancer

    Ludmil B. Alexandrov;Serena Nik-Zainal;Serena Nik-Zainal;David C. Wedge;Samuel A. J. R. Aparicio

  • Genomics of Drug Sensitivity in Cancer (GDSC): a resource for therapeutic biomarker discovery in cancer cells

    Wanjuan Yang;Jorge Soares;Patricia Greninger;Elena J. Edelman

  • Pan-cancer analysis of whole genomes

    Peter J. Campbell;Gad Getz;Jan O. Korbel;Joshua M. Stuart

  • Systematic identification of genomic markers of drug sensitivity in cancer cells

    Mathew J. Garnett;Elena J. Edelman;Sonja J. Heidorn;Christopher Greenman;Christopher Greenman

  • A chromatin-mediated reversible drug-tolerant state in cancer cell subpopulations

    Sreenath V. Sharma;Diana Y. Lee;Bihua Li;Margaret P. Quinlan

  • COSMIC: exploring the world's knowledge of somatic mutations in human cancer

    Simon A. Forbes;David Beare;Prasad Gunasekaran;Kenric Leung

  • Prospective Derivation of a Living Organoid Biobank of Colorectal Cancer Patients

    Marc van de Wetering;Hayley E. Francies;Joshua M. Francis;Joshua M. Francis;Gergana Bounova

  • Clinical Features and Outcome of Patients With Non–Small-Cell Lung Cancer Who Harbor EML4-ALK

    Alice T. Shaw;Beow Y. Yeap;Mari Mino-Kenudson;Subba R. Digumarthy

  • A Landscape of Pharmacogenomic Interactions in Cancer

    Francesco Iorio;Francesco Iorio;Theo A. Knijnenburg;Theo A. Knijnenburg;Daniel J. Vis;Graham R. Bignell

  • The evolutionary history of lethal metastatic prostate cancer.

    Gunes Gundem;Peter Van Loo;Peter Van Loo;Peter Van Loo;Barbara Kremeyer;Ludmil B. Alexandrov

  • Patterns of somatic structural variation in human cancer genomes

    Yilong Li;Nicola D Roberts;Jeremiah A Wala;Jeremiah A Wala;Ofer Shapira;Ofer Shapira

  • A CRISPR Dropout Screen Identifies Genetic Vulnerabilities and Therapeutic Targets in Acute Myeloid Leukemia

    Konstantinos Tzelepis;Hiroko Koike-Yusa;Etienne De Braekeleer;Yilong Li

  • Targeting MYCN in Neuroblastoma by BET Bromodomain Inhibition

    Alexandre Puissant;Stacey M. Frumm;Gabriela Alexe;Christopher F. Bassil

  • Low MITF/AXL ratio predicts early resistance to multiple targeted drugs in melanoma.

    Judith Müller;Oscar Krijgsman;Jennifer Tsoi;Lidia Robert

  • Elevated CRAF as a Potential Mechanism of Acquired Resistance to BRAF Inhibition in Melanoma

    Clara Montagut;Sreenath V. Sharma;Toshi Shioda;Ultan McDermott

  • Machine Learning Prediction of Cancer Cell Sensitivity to Drugs Based on Genomic and Chemical Properties

    Michael P. Menden;Francesco Iorio;Francesco Iorio;Mathew Garnett;Ultan McDermott

  • Pharmacogenomic agreement between two cancer cell line data sets

    Nicolas Stransky;Mahmoud Ghandi

  • MED12 Controls the Response to Multiple Cancer Drugs through Regulation of TGF-β Receptor Signaling.

    Sidong Huang;Michael Hölzel;Theo Knijnenburg;Andreas Schlicker

  • Genomic Alterations of Anaplastic Lymphoma Kinase May Sensitize Tumors to Anaplastic Lymphoma Kinase Inhibitors

    Ultan McDermott;A. John Iafrate;Nathanael S. Gray;Toshi Shioda

  • The evolutionary history of lethal metastatic prostate cancer

    G Gundem;P Van Loo;B Kremeyer;L B Alexandrov

Frequent Co-Authors

Mathew J. Garnett
Mathew J. Garnett Wellcome Sanger Institute
Peter J. Campbell
Peter J. Campbell Wellcome Sanger Institute
Michael R. Stratton
Michael R. Stratton Wellcome Sanger Institute
Cyril H. Benes
Cyril H. Benes Harvard University
Peter Van Loo
Peter Van Loo The Francis Crick Institute
David C. Wedge
David C. Wedge University of Manchester
Graham R. Bignell
Graham R. Bignell Wellcome Sanger Institute
Julio Saez-Rodriguez
Julio Saez-Rodriguez Heidelberg University
Colin Cooper
Colin Cooper University of East Anglia
Ludmil B. Alexandrov
Ludmil B. Alexandrov University of California, San Diego

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