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Hirotatsu Kojima

Hirotatsu Kojima

D-Index & Metrics

Chemistry

D-Index
47
Citations
15182
World Ranking
15464
National Ranking
1210

Overview

Hirotatsu Kojima is affiliated with the University of Tokyo in Japan and has focused their research on Biochemistry, Genetics and Molecular Biology, as well as Medicine. Their work spans multiple subfields including Molecular Biology, Immunology, Infectious Diseases, Oncology, and Physiology.

The research topics that Kojima has addressed include:

  • Genomics, phytochemicals, and oxidative stress
  • Glutathione Transferases and Polymorphisms
  • Computational Drug Discovery Methods
  • Receptor Mechanisms and Signaling
  • Endoplasmic Reticulum Stress and Disease
  • ATP Synthase and ATPases Research
  • Immune cells in cancer

Among recent papers associated with Kojima are:

  • Targeting FROUNT with disulfiram suppresses macrophage accumulation and its tumor-promoting properties, 2020, Nature Communications
  • Organoid-derived intestinal epithelial cells are a suitable model for preclinical toxicology and pharmacokinetic studies, 2022, iScience
  • Molecular action of larvicidal flavonoids on ecdysteroidogenic glutathione S-transferase Noppera-bo in Aedes aegypti, 2022, BMC Biology
  • Inhibitors of the protein-protein interaction between phosphorylated p62 and Keap1 attenuate chemoresistance in a human hepatocellular carcinoma cell line, 2020, Free Radical Research
  • Drug cytotoxicity screening using human intestinal organoids propagated with extensive cost-reduction strategies, 2023, Scientific Reports

Frequent coauthors in Kojima's publications include Takayoshi Okabe, Tetsuo Nagano, Riyo Imamura, Yuuta Fujikawa, and Toshiya Senda.

The scientist has published several articles in venues such as Scientific Reports, Biochemical and Biophysical Research Communications, iScience, SSRN Electronic Journal, and Nature Communications. The highest number of publications appear in Scientific Reports and Biochemical and Biophysical Research Communications.

Best Publications

  • Detection and Imaging of Nitric Oxide with Novel Fluorescent Indicators: Diaminofluoresceins

    Hirotatsu Kojima;Naoki Nakatsubo;Kazuya Kikuchi;Shigenori Kawahara

  • Highly sensitive fluorescence probes for nitric oxide based on boron dipyrromethene chromophore-rational design of potentially useful bioimaging fluorescence probe.

    Yu Gabe;Yasuteru Urano;Kazuya Kikuchi;Hirotatsu Kojima

  • Development of an iminocoumarin-based zinc sensor suitable for ratiometric fluorescence imaging of neuronal zinc.

    Kensuke Komatsu;Yasuteru Urano;Hirotatsu Kojima;Tetsuo Nagano

  • Design and Synthesis of a Library of BODIPY-Based Environmental Polarity Sensors Utilizing Photoinduced Electron-Transfer-Controlled Fluorescence ON/OFF Switching

    Hisato Sunahara;Yasuteru Urano;Hirotatsu Kojima;Tetsuo Nagano

  • Development of a highly specific rhodamine-based fluorescence probe for hypochlorous acid and its application to real-time imaging of phagocytosis.

    Suguru Kenmoku;Yasuteru Urano;Hirotatsu Kojima;Tetsuo Nagano

  • Fluorescent Indicators for Imaging Nitric Oxide Production

    Hirotatsu Kojima;Yasuteru Urano;Kazuya Kikuchi;Tsunehiko Higuchi

  • Selective zinc sensor molecules with various affinities for Zn2+, revealing dynamics and regional distribution of synaptically released Zn2+ in hippocampal slices.

    Kensuke Komatsu;Kazuya Kikuchi;Hirotatsu Kojima;Yasuteru Urano

  • Development of a ratiometric fluorescent zinc ion probe in near-infrared region, based on tricarbocyanine chromophore.

    Kazuki Kiyose;Hirotatsu Kojima;Yasuteru Urano;Tetsuo Nagano

  • Development and application of a near-infrared fluorescence probe for oxidative stress based on differential reactivity of linked cyanine dyes.

    Daihi Oushiki;Hirotatsu Kojima;Takuya Terai;Makoto Arita

  • Mechanism-based molecular design of highly selective fluorescence probes for nitrative stress.

    Tasuku Ueno;Yasuteru Urano;Hirotatsu Kojima;Tetsuo Nagano

  • Highly Sensitive Near-Infrared Fluorescent Probes for Nitric Oxide and Their Application to Isolated Organs

    Eita Sasaki;Hirotatsu Kojima;Hiroaki Nishimatsu;Yasuteru Urano

  • Direct evidence of nitric oxide production from bovine aortic endothelial cells using new fluorescence indicators: diaminofluoresceins

    Naoki Nakatsubo;Hirotatsu Kojima;Kazuya Kikuchi;Hiroshi Nagoshi

  • Development of a Zinc Ion-Selective Luminescent Lanthanide Chemosensor for Biological Applications

    Kenjiro Hanaoka;Kazuya Kikuchi;Hirotatsu Kojima;Yasuteru Urano

  • A Thiol-Reactive Fluorescence Probe Based on Donor-Excited Photoinduced Electron Transfer: Key Role of Ortho Substitution

    Takuya Matsumoto;Yasuteru Urano;Takuji Shoda;Hirotatsu Kojima,†,§ and

  • Rational Principles for Modulating Fluorescence Properties of Fluorescein

    Tasuku Ueno;Yasuteru Urano;Ken-Ichi Setsukinai;Hideo Takakusa

  • Rational design of ratiometric near-infrared fluorescent pH probes with various pKa values, based on aminocyanine

    Takuya Myochin;Kazuki Kiyose;Kenjiro Hanaoka;Hirotatsu Kojima

  • Design and synthesis of fluorescent probes for selective detection of highly reactive oxygen species in mitochondria of living cells.

    Yuichiro Koide;Yasuteru Urano;Suguru Kenmoku;Hirotatsu Kojima

  • Bioimaging of Nitric Oxide with Fluorescent Indicators Based on the Rhodamine Chromophore

    Hirotatsu Kojima;Miki Hirotani;Naoki Nakatsubo;Kazuya Kikuchi

  • DEVELOPMENT OF A FLUORESCENT INDICATOR FOR NITRIC OXIDE BASED ON THE FLUORESCEIN CHROMOPHORE

    Hirotatsu Kojima;Kuniko Sakurai;Kazuya Kikuchi;Shigenori Kawahara

  • Functional Near‐Infrared Fluorescent Probes

    Kazuki Kiyose;Hirotatsu Kojima;Tetsuo Nagano

  • Selective detection of zinc ions with novel luminescent lanthanide probes.

    Kenjiro Hanaoka;Kazuya Kikuchi;Kazuya Kikuchi;Hirotatsu Kojima;Yasuteru Urano

Frequent Co-Authors

Tetsuo Nagano
Tetsuo Nagano University of Tokyo
Yasuteru Urano
Yasuteru Urano University of Tokyo
Kazuya Kikuchi
Kazuya Kikuchi Osaka University
Kenjiro Hanaoka
Kenjiro Hanaoka Keio University
Takuya Terai
Takuya Terai University of Tokyo
Toru Komatsu
Toru Komatsu University of Tokyo
Yasunobu Hirata
Yasunobu Hirata University of Tokyo
Junken Aoki
Junken Aoki Tohoku University
Hiroshi Nishimasu
Hiroshi Nishimasu University of Tokyo
Osamu Nureki
Osamu Nureki University of Tokyo

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