Sadaaki Iwanaga

Research.com Recognitions

• 2023 - Research.com Biology and Biochemistry in Japan Leader Award

Overview

Best Publications

• Recent advances in the innate immunity of invertebrate animals.

  Sadaaki Iwanaga;Bok Luel Lee

  1025
  Citations

• Tachyplesin, a class of antimicrobial peptide from the hemocytes of the horseshoe crab (Tachypleus tridentatus). Isolation and chemical structure.

  T Nakamura;H Furunaka;T Miyata;F Tokunaga

  762
  Citations

• New fluorogenic substrates for .ALPHA.-thrombin, factor Xa, kallikreins, and urokinase.

  Takashi Morita;Hisao Kato;Sadaaki Iwanaga;Katsumi Takada

  537
  Citations

• Cloning and sequence analysis of cDNA for the luminescent protein aequorin

  S Inouye;M Noguchi;Y Sakaki;Y Takagi

  480
  Citations

• Antimicrobial Peptides, Isolated from Horseshoe Crab Hemocytes, Tachyplesin II, and Polyphemusins I and II: Chemical Structures and Biological Activity

  Toshiyuki Miyata;Fuminori Tokunaga;Takashi Yoneya;Katsuhiro Yoshikawa

  423
  Citations

• An immune-responsive Serpin regulates the melanization cascade in Drosophila.

  Ennio De Gregorio;Sung Jun Han;Won Jae Lee;Min Ji Baek

  417
  Citations

• New types of clotting factors and defense molecules found in horseshoe crab hemolymph: their structures and functions.

  Sadaaki Iwanaga;Shun Ichiro Kawabata;Tatsushi Muta

  406
  Citations

• The role of hemolymph coagulation in innate immunity

  Tatsushi Muta;Sadaaki Iwanaga

  371
  Citations

• Highly sensitive peptide‐4‐methylcoumaryl‐7‐amide substrates for blood‐clotting proteases and trypsin

  Shun‐Ichiro ‐I Kawabata;Takako Miura;Takashi Morita;Hisao Kato

  366
  Citations

• A new (1 → 3)-β-D-glucan-mediated coagulation pathway found in limulus amebocytes

  Takashi Morita;Shigenori Tanaka;Takanori Nakamura;Sadaaki Iwanaga

  340
  Citations

• The molecular basis of innate immunity in the horseshoe crab

  Sadaaki Iwanaga

  332
  Citations

• New Directions in Invertebrate Immunology

  Kenneth Söderhäll;Sadaaki Iwanaga;Gerardo R. Vasta

  325
  Citations

• Horseshoe crab acetyl group-recognizing lectins involved in innate immunity are structurally related to fibrinogen.

  Soutaro Gokudan;Tatsushi Muta;Ryoko Tsuda;Kumiko Koori

  319
  Citations

• Chromogenic substrates for horseshoe crab clotting enzyme. Its application for the assay of bacterial endotoxins.

  Sadaaki Iwanaga;Takashi Morita;Toshie Harada;Shin Nakamura

  309
  Citations

• Coagulation factor X activating enzyme from Russell's viper venom (RVV-X). A novel metalloproteinase with disintegrin (platelet aggregation inhibitor)-like and C-type lectin-like domains.

  H. Takeya;S. Nishida;T. Miyata;S.-I. Kawada

  291
  Citations

• Antimicrobial peptide, tachyplesin I, isolated from hemocytes of the horseshoe crab (Tachypleus tridentatus). NMR determination of the beta-sheet structure.

  K. Kawano;T. Yoneya;T. Miyata;K. Yoshikawa

  269
  Citations

• A Novel Big Defensin Identified in Horseshoe Crab Hemocytes: Isolation, Amino Acid Sequence, and Antibacterial Activity

  Tetsu Saito;Shun Ichiro Kawabata;Takeshi Shigenaga;Yoko Takayenoki

  257
  Citations

• Snake venom metalloproteinases: structure, function and relevance to the mammalian ADAM/ADAMTS family proteins.

  Soichi Takeda;Hiroyuki Takeya;Sadaaki Iwanaga

  254
  Citations

• Limulus factor C. An endotoxin-sensitive serine protease zymogen with a mosaic structure of complement-like, epidermal growth factor-like, and lectin-like domains.

  T Muta;T Miyata;Y Misumi;F Tokunaga

  254
  Citations

• Limulus anti-LPS factor: An anticoagulant which inhibits the endotoxin-mediated activation of Limulus coagulation system

  Shigenori Tanaka;Takanori Nakamura;Takashi Morita;Sadaaki Iwanaga

  251
  Citations