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Mutsuo Sekiguchi

Mutsuo Sekiguchi

D-Index & Metrics

Molecular Biology

D-Index
80
Citations
20264
World Ranking
1011
National Ranking
76

Overview

Mutsuo Sekiguchi is affiliated with Kyushu University in Japan and has contributed extensively to the fields of Medicine and Biochemistry, Genetics and Molecular Biology. Their research spans multiple subfields, including Molecular Biology, Cardiology and Cardiovascular Medicine, Cancer Research, Surgery, and Pulmonary and Respiratory Medicine.

The scientist's work covers a range of main topics such as Cancer Genomics and Diagnostics, Neuroblastoma Research and Treatments, Epigenetics and DNA Methylation, Acute Lymphoblastic Leukemia research, Cancer, Hypoxia, and Metabolism, Cardiac Imaging and Diagnostics, and Hepatocellular Carcinoma Treatment and Prognosis.

Among their recent publications are several notable papers:

  • "Integrated multiomics analysis of hepatoblastoma unravels its heterogeneity and provides novel druggable targets," 2020, npj Precision Oncology
  • "Multi-omics analysis defines highly refractory RAS burdened immature subgroup of infant acute lymphoblastic leukemia," 2022, Nature Communications
  • "Single-cell multiomics reveals the interplay of clonal evolution and cellular plasticity in hepatoblastoma," 2024, Nature Communications
  • "Evaluation of changes in oral health-related quality of life over time in patients with Sjögren's syndrome," 2020, Modern Rheumatology
  • "Urinary extracellular vesicles signature for diagnosis of kidney disease," 2022, iScience

Sekiguchi has frequently published in journals such as Pediatric Blood & Cancer, Nature Communications, Oncogene, Heart and Vessels, and the International Journal of Hematology.

Frequent collaborators include Motohiro Kato, Junko Takita, Kentaro Watanabe, Mitsuteru Hiwatari, and Aiko Sato-Otsubo, evidencing a consistent research network in their scientific work.

Best Publications

  • Mutt protein specifically hydrolyses a potent mutagenic substrate for dna synthesis

    Hisaji Maki;Mutsuo Sekiguchi

  • Targeted disruption of the Rad51 gene leads to lethality in embryonic mice.

    T Tsuzuki;Y Fujii;K Sakumi;Y Tominaga

  • Regulation and expression of the adaptive response to alkylating agents.

    Tomas Lindahl;Barbara Sedgwick;Mutsuo Sekiguchi;Yusaku Nakabeppu

  • Cloning and expression of cDNA for a human enzyme that hydrolyzes 8-oxo-dGTP, a mutagenic substrate for DNA synthesis.

    K. Sakumi;M. Furuichi;T. Tsuzuki;T. Kakuma

  • Hydrolytic elimination of a mutagenic nucleotide, 8-oxodGTP, by human 18-kilodalton protein: sanitization of nucleotide pool.

    Jin-Yao Mo;Hisaji Maki;Mutsuo Sekiguchi

  • Spontaneous tumorigenesis in mice defective in the MTH1 gene encoding 8-oxo-dGTPase

    Teruhisa Tsuzuki;Akinori Egashira;Hisato Igarashi;Tomoo Iwakuma

  • Transforming gene from human stomach cancers and a noncancerous portion of stomach mucosa.

    Hiromi Sakamoto;Midori Mori;Masanori Taira;Teruhiko Yoshida

  • Counteraction by MutT Protein of Transcriptional Errors Caused by Oxidative Damage

    F. Taddei;H. Hayakawa;H. Hayakawa;M.-F. Bouton;M.-F. Bouton;A.-M. Cirinesi;A.-M. Cirinesi

  • Isolation and characterization of the active cDNA of the human cell cycle gene (RCC1) involved in the regulation of onset of chromosome condensation.

    M Ohtsubo;R Kai;N Furuno;T Sekiguchi

  • Ogg1 Knockout-associated Lung Tumorigenesis and Its Suppression by Mth1 Gene Disruption

    Kunihiko Sakumi;Yohei Tominaga;Masato Furuichi;Ping Xu

  • Restoration of ultraviolet-induced unscheduled DNA synthesis of xeroderma pigmentosum cells by the concomitant treatment with bacteriophage T4 endonuclease V and HVJ (Sendai virus).

    Kiyoji Tanaka;Mutsuo Sekiguchi;Yoshio Okada

  • MUTANTS OF ESCHERICHIA COLI PERMEABLE TO ACTINOMYCIN

    Mutsuo Sekiguchi;Shoko Iida

  • Intracellular Localization of 8-Oxo-dGTPase in Human Cells, with Special Reference to the Role of the Enzyme in Mitochondria

    Dongchon Kang;Jun-ichi Nishida;Akihiro Iyama;Yusaku Nakabeppu

  • T4 Endonuclease Involved in Repair of DNA

    Seiichi Yasuda;Mutsuo Sekiguchi

  • Generation and Elimination of 8-Oxo-7,8-dihydro-2'-deoxyguanosine 5'-Triphosphate, a Mutagenic Substrate for DNA Synthesis, in Human Cells

    Hiroshi Hayakawa;Akinobu Taketomi;Kunihiko Sakumi;Michihiko Kuwano

  • Silencing effect of CpG island hypermethylation and histone modifications on O6-methylguanine-DNA methyltransferase (MGMT) gene expression in human cancer

    Tetsuji Nakagawachi;Hidenobu Soejima;Takeshi Urano;Wei Zhao

  • O6-methylguanine-DNA methyltransferase protects against nitrosamine-induced hepatocarcinogenesis

    Yoko Nakatsuru;Shoichi Matsukuma;Nobuo Nemoto;Haruo Sugano

  • Replication of plasmid pSC101 in Escherichia coli K12: requirement for dnaA function.

    Kohji Hasunuma;Mutsuo Sekiguchi

  • Three-Dimensional Structure of a DNA Repair Enzyme, 3-Methyladenine DNA Glycosylase II, from Escherichia coli

    Yuriko Yamagata;Masato Kato;Kyoko Odawara;Yoshiteru Tokuno

  • Targeted disruption of the DNA repair methyltransferase gene renders mice hypersensitive to alkylating agent.

    Teruhisa Tsuzuki;Sakumi Kunihiko;Akiko Shiraishi;Hisaya Kawate

Frequent Co-Authors

Yusaku Nakabeppu
Yusaku Nakabeppu Kyushu University
Kunihiko Sakumi
Kunihiko Sakumi Kyushu University
Takashi Horiuchi
Takashi Horiuchi National Institutes of Natural Sciences
Takeharu Nishimoto
Takeharu Nishimoto Kyushu University
Shun-ichiro Kawabata
Shun-ichiro Kawabata Kyushu University
Motoya Katsuki
Motoya Katsuki University of Tokyo
Kiyoji Tanaka
Kiyoji Tanaka University of Tsukuba
Keizo Inoue
Keizo Inoue University of Tokyo
Ichiro Kudo
Ichiro Kudo Showa University
Yoshihiko Maehara
Yoshihiko Maehara Kyushu University

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