Kunihiko Sakumi

Overview

Best Publications

• Targeted disruption of the Rad51 gene leads to lethality in embryonic mice.

  T Tsuzuki;Y Fujii;K Sakumi;Y Tominaga

  1173
  Citations

• Cloning and expression of cDNA for a human enzyme that hydrolyzes 8-oxo-dGTP, a mutagenic substrate for DNA synthesis.

  K. Sakumi;M. Furuichi;T. Tsuzuki;T. Kakuma

  621
  Citations

• Oxidative damage in nucleic acids and Parkinson's disease.

  Yusaku Nakabeppu;Daisuke Tsuchimoto;Hiroo Yamaguchi;Kunihiko Sakumi

  327
  Citations

• Mutagenesis and carcinogenesis caused by the oxidation of nucleic acids

  Yusaku Nakabeppu;Kunihiko Sakumi;Katsumi Sakamoto;Daisuke Tsuchimoto

  316
  Citations

• Ogg1 Knockout-associated Lung Tumorigenesis and Its Suppression by Mth1 Gene Disruption

  Kunihiko Sakumi;Yohei Tominaga;Masato Furuichi;Ping Xu

  269
  Citations

• Two distinct pathways of cell death triggered by oxidative damage to nuclear and mitochondrial DNAs

  Sugako Oka;Mizuki Ohno;Daisuke Tsuchimoto;Kunihiko Sakumi

  250
  Citations

• Hydrogen in Drinking Water Reduces Dopaminergic Neuronal Loss in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine Mouse Model of Parkinson's Disease

  Kyota Fujita;Toshihiro Seike;Noriko Yutsudo;Mizuki Ohno

  246
  Citations

• Generation and Elimination of 8-Oxo-7,8-dihydro-2'-deoxyguanosine 5'-Triphosphate, a Mutagenic Substrate for DNA Synthesis, in Human Cells

  Hiroshi Hayakawa;Akinobu Taketomi;Kunihiko Sakumi;Michihiko Kuwano

  221
  Citations

• Human APE2 protein is mostly localized in the nuclei and to some extent in the mitochondria, while nuclear APE2 is partly associated with proliferating cell nuclear antigen

  Daisuke Tsuchimoto;Yasunari Sakai;Kunihiko Sakumi;Kenichi Nishioka

  193
  Citations

• Methylnitrosourea-induced Tumorigenesis in MGMT Gene Knockout Mice

  Kunihiko Sakumi;Akiko Shiraishi;Seiichiro Shimizu;Teruhisa Tsuzuki

  187
  Citations

• SEPARATION OF KILLING AND TUMORIGENIC EFFECTS OF AN ALKYLATING AGENT IN MICE DEFECTIVE IN TWO OF THE DNA REPAIR GENES

  Hisaya Kawate;Kunihiko Sakumi;Teruhisa Tsuzuki;Yoko Nakatsuru

  178
  Citations

• 8-oxoguanine causes spontaneous de novo germline mutations in mice

  Mizuki Ohno;Kunihiko Sakumi;Ryutaro Fukumura;Masato Furuichi

  168
  Citations

• An oxidized purine nucleoside triphosphatase, MTH1 suppresses cell death caused by oxidative stress

  Daisuke Yoshimura;Kunihiko Sakumi;Mizuki Ohno;Yasunari Sakai

  161
  Citations

• 8-Oxoguanine Formation Induced by Chronic UVB Exposure Makes Ogg1 Knockout Mice Susceptible to Skin Carcinogenesis

  Makoto Kunisada;Kunihiko Sakumi;Yohei Tominaga;Arief Budiyanto

  151
  Citations

• MUTYH-null mice are susceptible to spontaneous and oxidative stress induced intestinal tumorigenesis.

  Katsumi Sakamoto;Yohei Tominaga;Kazumi Yamauchi;Kazumi Yamauchi;Yoshimichi Nakatsu

  146
  Citations

• Structures and functions of DNA glycosylases.

  Kunihiko Sakumi;Mutsuo Sekiguchi

  140
  Citations

• Comparative profiling of cortical gene expression in Alzheimer's disease patients and mouse models demonstrates a link between amyloidosis and neuroinflammation.

  Erika Castillo;Julio Leon;Julio Leon;Guianfranco Mazzei;Nona Abolhassani

  140
  Citations

• 8-Oxoguanine DNA Glycosylase (OGG1) Deficiency Increases Susceptibility to Obesity and Metabolic Dysfunction

  Harini Sampath;Vladimir Vartanian;M. Rick Rollins;Kunihiko Sakumi

  140
  Citations

• The defense mechanisms in mammalian cells against oxidative damage in nucleic acids and their involvement in the suppression of mutagenesis and cell death.

  Yusaku Nakabeppu;Daisuke Tsuchimoto;Masato Furuichi;Kunihiko Sakumi

  139
  Citations

• 8-Oxoguanine causes neurodegeneration during MUTYH-mediated DNA base excision repair

  Zijing Sheng;Sugako Oka;Daisuke Tsuchimoto;Nona Abolhassani

  138
  Citations