mutsuo sekiguchi

Overview

Best Publications

• Targeted disruption of the Rad51 gene leads to lethality in embryonic mice.

  T Tsuzuki;Y Fujii;K Sakumi;Y Tominaga

  1173
  Citations

• Functional cooperation of MutT, MutM and MutY proteins in preventing mutations caused by spontaneous oxidation of guanine nucleotide in Escherichia coli

  Tatsurou Tajiri;Hisaji Maki;Mutsuo Sekiguchi

  476
  Citations

• Spontaneous tumorigenesis in mice defective in the MTH1 gene encoding 8-oxo-dGTPase

  Teruhisa Tsuzuki;Akinori Egashira;Hisato Igarashi;Tomoo Iwakuma

  341
  Citations

• Counteraction by MutT Protein of Transcriptional Errors Caused by Oxidative Damage

  F. Taddei;H. Hayakawa;H. Hayakawa;M.-F. Bouton;M.-F. Bouton;A.-M. Cirinesi;A.-M. Cirinesi

  333
  Citations

• Oxidative nucleotide damage: Consequences and prevention

  Mutsuo Sekiguchi;Teruhisa Tsuzuki

  295
  Citations

• Intracellular Localization of 8-Oxo-dGTPase in Human Cells, with Special Reference to the Role of the Enzyme in Mitochondria

  Dongchon Kang;Jun-ichi Nishida;Akihiro Iyama;Yusaku Nakabeppu

  224
  Citations

• Generation and Elimination of 8-Oxo-7,8-dihydro-2'-deoxyguanosine 5'-Triphosphate, a Mutagenic Substrate for DNA Synthesis, in Human Cells

  Hiroshi Hayakawa;Akinobu Taketomi;Kunihiko Sakumi;Michihiko Kuwano

  221
  Citations

• Silencing effect of CpG island hypermethylation and histone modifications on O6-methylguanine-DNA methyltransferase (MGMT) gene expression in human cancer

  Tetsuji Nakagawachi;Hidenobu Soejima;Takeshi Urano;Wei Zhao

  199
  Citations

• The synthesis of messenger RNA without protein synthesis: II. Synthesis of phage-induced RNA and sequential enzyme production*

  Mutsuo Sekiguchi;Seymour S. Cohen

  198
  Citations

• Methylnitrosourea-induced Tumorigenesis in MGMT Gene Knockout Mice

  Kunihiko Sakumi;Akiko Shiraishi;Seiichiro Shimizu;Teruhisa Tsuzuki

  187
  Citations

• SEPARATION OF KILLING AND TUMORIGENIC EFFECTS OF AN ALKYLATING AGENT IN MICE DEFECTIVE IN TWO OF THE DNA REPAIR GENES

  Hisaya Kawate;Kunihiko Sakumi;Teruhisa Tsuzuki;Yoko Nakatsuru

  178
  Citations

• Three-Dimensional Structure of a DNA Repair Enzyme, 3-Methyladenine DNA Glycosylase II, from Escherichia coli

  Yuriko Yamagata;Masato Kato;Kyoko Odawara;Yoshiteru Tokuno

  175
  Citations

• Targeted disruption of the DNA repair methyltransferase gene renders mice hypersensitive to alkylating agent.

  Teruhisa Tsuzuki;Sakumi Kunihiko;Akiko Shiraishi;Hisaya Kawate

  170
  Citations

• Metabolic fate of oxidized guanine ribonucleotides in mammalian cells

  Hiroshi Hayakawa;Anders Hofer;Lars Thelander;Shigetaka Kitajima

  170
  Citations

• A novel mechanism for preventing mutations caused by oxidation of guanine nucleotides

  Toru Ishibashi;Hiroshi Hayakawa;Mutsuo Sekiguchi

  150
  Citations

• Binding capacity of human YB-1 protein for RNA containing 8-oxoguanine.

  Hiroshi Hayakawa;Takeshi Uchiumi;Takao Fukuda;Megumi Ashizuka

  149
  Citations

• Mouse MTH2 protein which prevents mutations caused by 8-oxoguanine nucleotides.

  Jian-Ping Cai;Toru Ishibashi;Yasumitsu Takagi;Hiroshi Hayakawa

  142
  Citations

• Alkylation-induced apoptosis of embryonic stem cells in which the gene for DNA repair, methyltransferase, had been disrupted by gene targeting

  Yohei Tominaga;Teruhisa Tsuzuki;Akiko Shiraishi;Hisaya Kawate

  136
  Citations

• Mammalian enzymes for preventing transcriptional errors caused by oxidative damage

  Toru Ishibashi;Hiroshi Hayakawa;Riyoko Ito;Masayuki Miyazawa

  133
  Citations

• Human MTH3 (NUDT18) Protein Hydrolyzes Oxidized Forms of Guanosine and Deoxyguanosine Diphosphates: COMPARISON WITH MTH1 AND MTH2*

  Yasumitsu Takagi;Daiki Setoyama;Riyoko Ito;Hiroyuki Kamiya

  131
  Citations