What is he best known for?
The fields of study he is best known for:
His primary scientific interests are in Molecular biology, Biochemistry, DNA repair, Gene targeting and DNA.
His Molecular biology research includes themes of Mutation, Transversion, Mitochondrial matrix and HSPA2.
His DNA repair study introduces a deeper knowledge of Gene.
Mutsuo Sekiguchi has researched Gene in several fields, including Oxidative stress, dGTPase and DNA damage.
Mutsuo Sekiguchi interconnects Carcinogenesis and Methyltransferase in the investigation of issues within Gene targeting.
His study in DNA is interdisciplinary in nature, drawing from both Mutagenesis and Guanine.
His most cited work include:
- Targeted disruption of the Rad51 gene leads to lethality in embryonic mice. (713 citations)
- Functional cooperation of MutT, MutM and MutY proteins in preventing mutations caused by spontaneous oxidation of guanine nucleotide in Escherichia coli (293 citations)
- Spontaneous tumorigenesis in mice defective in the MTH1 gene encoding 8-oxo-dGTPase (253 citations)
What are the main themes of his work throughout his whole career to date?
His main research concerns Molecular biology, Biochemistry, DNA, Methyltransferase and RNA.
His Molecular biology research incorporates themes from Mutation, Gene, DNA repair, Gene targeting and Transversion.
In his research, dGTPase is intimately related to DNA damage, which falls under the overarching field of DNA repair.
His work deals with themes such as Carcinogenesis and Cell growth, which intersect with Gene targeting.
The study incorporates disciplines such as Protein structure, Mutagenesis and Binding site in addition to DNA.
His Methyltransferase study combines topics from a wide range of disciplines, such as Ratón, Cancer research, DNA mismatch repair and Carcinogen.
He most often published in these fields:
- Molecular biology (62.62%)
- Biochemistry (46.73%)
- DNA (33.64%)
What were the highlights of his more recent work (between 2010-2020)?
- RNA (18.69%)
- Biochemistry (46.73%)
- Cell biology (12.15%)
In recent papers he was focusing on the following fields of study:
Mutsuo Sekiguchi mainly focuses on RNA, Biochemistry, Cell biology, DNA and Molecular biology.
His RNA study incorporates themes from Oxidative stress, 8-Oxoguanine, Guanine, Nucleic acid and Messenger RNA.
His Cell biology research is multidisciplinary, relying on both Cleavage, Mutation, Apoptosis, Mutant and Induced pluripotent stem cell.
Mutsuo Sekiguchi focuses mostly in the field of Mutation, narrowing it down to matters related to Luciferase and, in some cases, Mutagenesis.
Mutsuo Sekiguchi has included themes like DNA damage, Protein kinase A, Gene knockdown, AMP-activated protein kinase and Cell growth in his Molecular biology study.
His Deoxyguanosine research includes elements of genomic DNA, Guanosine and DNA repair.
Between 2010 and 2020, his most popular works were:
- Human MTH3 (NUDT18) Protein Hydrolyzes Oxidized Forms of Guanosine and Deoxyguanosine Diphosphates: COMPARISON WITH MTH1 AND MTH2* (71 citations)
- Age-dependent increases in the oxidative damage of DNA, RNA, and their metabolites in normal and senescence-accelerated mice analyzed by LC-MS/MS: urinary 8-oxoguanosine as a novel biomarker of aging. (61 citations)
- Age-Dependent Accumulation of 8-Oxoguanine in the DNA and RNA in Various Rat Tissues (45 citations)
In his most recent research, the most cited papers focused on:
His primary areas of study are RNA, DNA, Biochemistry, Deoxyguanosine and Guanosine.
Mutsuo Sekiguchi interconnects 8-Oxoguanine, Messenger RNA, Gene expression and Cell biology in the investigation of issues within RNA.
His research on DNA often connects related topics like Molecular biology.
Mutsuo Sekiguchi studied Molecular biology and Urine that intersect with DNA damage, Oxidative phosphorylation and Urinary system.
His Deoxyguanosine research includes themes of Ribonucleotide, Nucleotide, Enzyme, Pyrophosphatases and Nucleoside.
His Guanosine research integrates issues from Oxidative stress and DNA replication.
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