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Genetics

D-Index
51
Citations
8129
World Ranking
3873
National Ranking
1673

Overview

Roel M. Schaaper is affiliated with the National Institutes of Health in the United States. Their research primarily spans the field of Biochemistry, Genetics and Molecular Biology, with significant contributions to Molecular Biology, Genetics, Structural Biology, Surfaces, Coatings and Films, and Radiation.

The scientist's work covers several main research topics including:

  • Advanced Electron Microscopy Techniques and Applications
  • DNA Repair Mechanisms
  • Electron and X-Ray Spectroscopy Techniques
  • Advanced X-ray Imaging Techniques
  • Bacterial Genetics and Biotechnology
  • Bacteriophages and microbial interactions
  • Evolution and Genetic Dynamics

Roel M. Schaaper has authored or co-authored multiple papers published in recognized scientific venues. Selected recent publications include:

  • "Beam image-shift accelerated data acquisition for near-atomic resolution single-particle cryo-electron tomography," 2021, Nature Communications
  • "Complete Genome Sequence of Escherichia coli BL21-AI," 2020, Microbiology Resource Announcements
  • "Beam image-shift accelerated data acquisition for near-atomic resolution single-particle cryo-electron tomography," 2020, bioRxiv (Cold Spring Harbor Laboratory)
  • "High-resolution structures of the SAMHD1 dGTPase homolog from Leeuwenhoekiella blandensis reveal a novel mechanism of allosteric activation by dATP," 2022, Journal of Biological Chemistry
  • "Mechanism by which T7 bacteriophage protein Gp1.2 inhibits Escherichia coli dGTPase," 2022, Proceedings of the National Academy of Sciences

The frequent co-authors collaborating with Roel M. Schaaper include:

  • Bradley P. Klemm
  • Mario J. Borgnia
  • Andrew P. Sikkema
  • Jonathan Bouvette
  • Hsuan-Fu Liu

The scientist's research has appeared multiple times in publication venues such as bioRxiv (Cold Spring Harbor Laboratory), Nature Communications, Microbiology Resource Announcements, Journal of Biological Chemistry, and Proceedings of the National Academy of Sciences.

Best Publications

  • Base selection, proofreading, and mismatch repair during DNA replication in Escherichia coli.

    R M Schaaper

  • Infidelity of DNA synthesis associated with bypass of apurinic sites

    Roeland M. Schaaper;Thomas A. Kunkel;Lawrence A. Loeb

  • Spectra of spontaneous mutations in Escherichia coli strains defective in mismatch correction: the nature of in vivo DNA replication errors.

    Roel M. Schaaper;Ronnie L. Dunn

  • Mechanisms of spontaneous mutagenesis: An analysis of the spectrum of spontaneous mutation in the Escherichia coli lacI gene

    Roel M. Schaaper;Bryan N. Danforth;Barry W. Glickman

  • Mechanisms of mutagenesis in the Escherichia coli mutator mutD5: role of DNA mismatch repair.

    Roel M. Schaaper

  • Spontaneous mutation in the Escherichia coli lacI gene.

    R M Schaaper;R L Dunn

  • Mutants in the Exo I motif of Escherichia coli dnaQ: defective proofreading and inviability due to error catastrophe

    Iwona J. Fijalkowska;Roel M. Schaaper

  • Depurination causes mutations in SOS-induced cells.

    Roeland M. Schaaper;Lawrence A. Loeb

  • Unequal fidelity of leading strand and lagging strand DNA replication on the Escherichia coli chromosome

    Iwona J. Fijalkowska;Piotr Jonczyk;Magdalena Maliszewska Tkaczyk;Malgorzata Bialoskorska

  • The extreme mutator effect of Escherichia coli mutD5 results from saturation of mismatch repair by excessive DNA replication errors.

    R M Schaaper;M Radman

  • DNA replication fidelity in Escherichia coli: a multi‐DNA polymerase affair

    Iwona J. Fijalkowska;Roel M. Schaaper;Piotr Jonczyk

  • Depurination-induced infidelity of deoxyribonucleic acid synthesis with purified deoxyribonucleic acid replication proteins in vitro.

    Thomas A. Kunkel;Roeland M. Schaaper;Lawrence A. Loeb

  • Mechanisms of ultraviolet-induced mutation. Mutational spectra in the Escherichia coli lacI gene for a wild-type and an excision-repair-deficient strain.

    Roel M. Schaaper;Ronnie L. Dunn;Barry W. Glickman

  • Interactions among the Escherichia coli mutT, mutM, and mutY damage prevention pathways.

    Robert G. Fowler;Steven J. White;Carol Koyama;Sean C. Moore

  • Genetic requirements and mutational specificity of the Escherichia coli SOS mutator activity.

    Iwona J. Fijalkowska;Ronnie L. Dunn;Roel M. Schaaper

  • Rapid repeated cloning of mutant lac repressor genes.

    Roel M. Schaaper;Bryan N. Danforth;Barry W. Glickman

  • On the fidelity of DNA replication. Effect of the next nucleotide on proofreading.

    T A Kunkel;R M Schaaper;R A Beckman;L A Loeb

  • Mutants of Escherichia coli with increased fidelity of DNA replication.

    I J Fijalkowska;R L Dunn;R M Schaaper

  • The C-C (6-4) UV photoproduct is mutagenic in Escherichia coli

    Barry W. Glickman;Roel M. Schaaper;William A. Haseltine;Ronnie L. Dunn

  • Transcription-repair coupling determines the strandedness of ultraviolet mutagenesis in Escherichia coli

    Adriana R. Oller;Iwona J. Fijalkowska;Ronnie L. Dunn;Roel M. Schaaper

Frequent Co-Authors

Barry W. Glickman
Barry W. Glickman University of Victoria
Youri I. Pavlov
Youri I. Pavlov University of Nebraska Medical Center
Robert E. London
Robert E. London National Institutes of Health
David M. DeMarini
David M. DeMarini Environmental Protection Agency
Thomas A. Kunkel
Thomas A. Kunkel National Institutes of Health
Lawrence A. Loeb
Lawrence A. Loeb University of Washington
Igor B. Rogozin
Igor B. Rogozin National Institutes of Health
Steffen Porwollik
Steffen Porwollik APEX Think Consulting
Charles S. McHenry
Charles S. McHenry University of Colorado Boulder
Michael McClelland
Michael McClelland University of California, Irvine

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