His primary areas of study are Molecular biology, Biochemistry, Ran, Cell biology and DNA replication factor CDT1. The concepts of his Molecular biology study are interwoven with issues in Chromatin, Premature chromosome condensation, Mitosis, Complementary DNA and Nuclear protein. His study looks at the relationship between Nuclear protein and topics such as Nuclear matrix, which overlap with Peptide sequence.
His Ran research incorporates elements of RANBP2, GTPase, Microtubule, Centrosome and Importin. His study in the fields of Transport protein under the domain of Cell biology overlaps with other disciplines such as Lipid bilayer, Inner membrane and Membrane transport protein. His DNA replication factor CDT1 research is multidisciplinary, incorporating elements of Origin recognition complex, Geminin and Licensing factor.
His main research concerns Molecular biology, Mutant, Cell biology, Ran and Biochemistry. His Molecular biology study incorporates themes from Premature chromosome condensation, Mutation, Gene, Mitosis and DNA. The study incorporates disciplines such as Complementary DNA, Cell culture, Protein subunit and Phosphorylation in addition to Mutant.
His Cell biology research incorporates themes from Cell cycle, Apoptosis and Cyclin D. His research in Ran intersects with topics in Guanine nucleotide exchange factor, GTPase, Saccharomyces cerevisiae, Nuclear protein and GTP'. His Nuclear protein study combines topics in areas such as Nuclear export signal, Nuclear transport, Messenger RNA and Nuclear pore.
Takeharu Nishimoto mainly focuses on Molecular biology, Cell biology, Mutant, Ran and Biochemistry. Takeharu Nishimoto has researched Molecular biology in several fields, including Chromatin, Schizosaccharomyces pombe, Guanine nucleotide exchange factor and Complementary DNA. His Complementary DNA research is multidisciplinary, incorporating perspectives in Microtubule and Immunoprecipitation.
His research integrates issues of Nuclear protein, Nuclear lamina and Chromosome segregation in his study of Cell biology. His Mutant research includes themes of Spindle apparatus, Cytokinesis, Mutation, DEAD box and RNA Helicase A. His Ran research is multidisciplinary, incorporating elements of Saccharomyces cerevisiae, Mitosis, Cell division, Multipolar spindles and RanGAP.
Takeharu Nishimoto mainly investigates Molecular biology, Cell biology, Licensing factor, Geminin and DNA replication. His Molecular biology study combines topics in areas such as Mutant, Microtubule, Guanine nucleotide exchange factor, DEAD box and RNA Helicase A. His Small GTPase and Transport protein study, which is part of a larger body of work in Cell biology, is frequently linked to Integral membrane protein and Membrane transport protein, bridging the gap between disciplines.
His research integrates issues of Endosome, Vacuolar protein sorting and Pleckstrin homology domain in his study of Small GTPase. The Licensing factor study combines topics in areas such as Chromatin, Ubiquitin and DNA replication factor CDT1. His Geminin study integrates concerns from other disciplines, such as Proteolysis, Origin recognition complex, Cyclin A and Cell division control protein 4.
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The Cdt1 protein is required to license DNA for replication in fission yeast.
Hideo Nishitani;Zoi Lygerou;Takeharu Nishimoto;Paul Nurse.
Nature (2000)
A giant nucleopore protein that binds Ran/TC4.
N. Yokoyama;N. Hayashi;T. Seki;N. Panté.
Nature (1995)
The RCC1 protein, a regulator for the onset of chromosome condensation locates in the nucleus and binds to DNA.
Motoaki Ohtsubo;Hiroshi Okazaki;Takeharu Nishimoto.
Journal of Cell Biology (1989)
Two E3 ubiquitin ligases, SCF-Skp2 and DDB1-Cul4, target human Cdt1 for proteolysis.
Hideo Nishitani;Nozomi Sugimoto;Vassilis Roukos;Yohsuke Nakanishi.
The EMBO Journal (2006)
Okadaic acid, a potent inhibitor of type 1 and type 2A protein phosphatases, activates cdc2/H1 kinase and transiently induces a premature mitosis-like state in BHK21 cells
K Yamashita;H Yasuda;J Pines;K Yasumoto.
The EMBO Journal (1990)
Budding yeast Dsk2p is a polyubiquitin-binding protein that can interact with the proteasome.
Minoru Funakoshi;Toru Sasaki;Takeharu Nishimoto;Hideki Kobayashi.
Proceedings of the National Academy of Sciences of the United States of America (2002)
ALS2, a novel guanine nucleotide exchange factor for the small GTPase Rab5, is implicated in endosomal dynamics
Asako Otomo;Shinji Hadano;Takeya Okada;Hikaru Mizumura.
Human Molecular Genetics (2003)
The human licensing factor for DNA replication Cdt1 accumulates in G1 and is destabilized after initiation of S-phase.
Hideo Nishitani;Stavros Taraviras;Zoi Lygerou;Takeharu Nishimoto.
Journal of Biological Chemistry (2001)
When Overexpressed, a Novel Centrosomal Protein, RanBPM, Causes Ectopic Microtubule Nucleation Similar to γ-Tubulin
Masafumi Nakamura;Hirohisa Masuda;Johji Horii;Kei Ichi Kuma.
Journal of Cell Biology (1998)
LOSS OF RCC1, A NUCLEAR DNA-BINDING PROTEIN, UNCOUPLES THE COMPLETION OF DNA REPLICATION FROM THE ACTIVATION OF CDC2 PROTEIN KINASE AND MITOSIS
H. Nishitani;M. Ohtsubo;K. Yamashita;H. Iida.
The EMBO Journal (1991)
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