Takeharu Nishimoto

Overview

Best Publications

• Formation and activation of a cyclin E-cdk2 complex during the G1 phase of the human cell cycle

  Koff A;Giordano A;Desai D;Yamashita K

  1442
  Citations

• The Cdt1 protein is required to license DNA for replication in fission yeast.

  Hideo Nishitani;Zoi Lygerou;Takeharu Nishimoto;Paul Nurse

  633
  Citations

• A giant nucleopore protein that binds Ran/TC4.

  N. Yokoyama;N. Hayashi;T. Seki;N. Panté

  583
  Citations

• The RCC1 protein, a regulator for the onset of chromosome condensation locates in the nucleus and binds to DNA.

  Motoaki Ohtsubo;Hiroshi Okazaki;Takeharu Nishimoto

  478
  Citations

• Two E3 ubiquitin ligases, SCF-Skp2 and DDB1-Cul4, target human Cdt1 for proteolysis.

  Hideo Nishitani;Nozomi Sugimoto;Vassilis Roukos;Yohsuke Nakanishi

  450
  Citations

• Structure of a Ran-binding domain complexed with Ran bound to a GTP analogue: implications for nuclear transport.

  Ingrid R. Vetter;Christine Nowak;Takeharu Nishimoto;Jürgen Kuhlmann

  431
  Citations

• Okadaic acid, a potent inhibitor of type 1 and type 2A protein phosphatases, activates cdc2/H1 kinase and transiently induces a premature mitosis-like state in BHK21 cells

  K Yamashita;H Yasuda;J Pines;K Yasumoto

  341
  Citations

• Budding yeast Dsk2p is a polyubiquitin-binding protein that can interact with the proteasome.

  Minoru Funakoshi;Toru Sasaki;Takeharu Nishimoto;Hideki Kobayashi

  334
  Citations

• ALS2, a novel guanine nucleotide exchange factor for the small GTPase Rab5, is implicated in endosomal dynamics

  Asako Otomo;Shinji Hadano;Takeya Okada;Hikaru Mizumura

  333
  Citations

• The human licensing factor for DNA replication Cdt1 accumulates in G1 and is destabilized after initiation of S-phase.

  Hideo Nishitani;Stavros Taraviras;Zoi Lygerou;Takeharu Nishimoto

  327
  Citations

• Novel G Proteins, Rag C and Rag D, Interact with GTP-binding Proteins, Rag A and Rag B

  Takeshi Sekiguchi;Eiji Hirose;Nobutaka Nakashima;Miki

  278
  Citations

• When Overexpressed, a Novel Centrosomal Protein, RanBPM, Causes Ectopic Microtubule Nucleation Similar to γ-Tubulin

  Masafumi Nakamura;Hirohisa Masuda;Johji Horii;Kei Ichi Kuma

  263
  Citations

• Ubc9p and the conjugation of SUMO-1 to RanGAP1 and RanBP2

  Hisato Saitoh;Duncan B. Sparrow;Tetsuo Shiomi;Robert T. Pu

  246
  Citations

• LOSS OF RCC1, A NUCLEAR DNA-BINDING PROTEIN, UNCOUPLES THE COMPLETION OF DNA REPLICATION FROM THE ACTIVATION OF CDC2 PROTEIN KINASE AND MITOSIS

  H Nishitani;M Ohtsubo;K Yamashita;H Iida

  216
  Citations

• Energy- and temperature-dependent transport of integral proteins to the inner nuclear membrane via the nuclear pore

  Tomoyuki Ohba;Eric C. Schirmer;Takeharu Nishimoto;Larry Gerace

  194
  Citations

• Proteolysis of DNA Replication Licensing Factor Cdt1 in S-phase Is Performed Independently of Geminin through Its N-terminal Region

  Hideo Nishitani;Zoi Lygerou;Takeharu Nishimoto

  179
  Citations

• GTP hydrolysis by Ran occurs at the nuclear pore complex in an early step of protein import.

  Frauke Melchior;Tinglu Guan;Nobuhiko Yokoyama;Takeharu Nishimoto

  174
  Citations

• An Arabidopsis thaliana cDNA complementing a hamster apoptosis suppressor mutant

  Patrick Gallois;Tomoko Makishima;Valérie Hecht;Barbara Despres

  172
  Citations

• A mutant form of the Ran/TC4 protein disrupts nuclear function in Xenopus laevis egg extracts by inhibiting the RCC1 protein, a regulator of chromosome condensation.

  M. Dasso;T. Seki;Y. Azuma;T. Ohba

  166
  Citations

• Formation and activation of a cyclin E-cdk2 complex during the G1 phase of the human cell cycle: Science 257, 1689–1694

  A. Koff;V. Dulic;E. Lees;S.I. Reed

  8
  Citations