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Molecular Biology

D-Index
69
Citations
16923
World Ranking
1474
National Ranking
115

Overview

Hiromi Sakamoto is affiliated with the National Cancer Research Institute, UK, and has an active role in research primarily situated in the United Kingdom. Their academic contributions span a broad set of topics within the fields of Biochemistry, Genetics and Molecular Biology, as well as Medicine.

Their research engages deeply with subfields including Molecular Biology, Cancer Research, Genetics, Pathology and Forensic Medicine, and Oncology. The main topics addressed in their work are:

  • MicroRNA in disease regulation
  • Genetic factors in colorectal cancer
  • Cancer-related molecular mechanisms research
  • RNA modifications and cancer
  • Cancer Genomics and Diagnostics
  • Circular RNAs in diseases
  • RNA Research and Splicing

Notable recent papers authored or co-authored by Hiromi Sakamoto include:

  • "A miRNA-based diagnostic model predicts resectable lung cancer in humans with high accuracy," 2020, Communications Biology
  • "Aberrant splicing isoforms detected by full-length transcriptome sequencing as transcripts of potential neoantigens in non-small cell lung cancer," 2021, Genome biology
  • "Genome-wide association meta-analysis identifies GP2 gene risk variants for pancreatic cancer," 2020, Nature Communications
  • "A novel combination of serum microRNAs for the detection of early gastric cancer," 2021, Gastric Cancer
  • "Prediction of tissue-of-origin of early stage cancers using serum miRNomes," 2022, JNCI Cancer Spectrum

Frequent co-authors in their research activities are:

  • Makoto Hirata
  • Teruhiko Yoshida
  • Ken Kato
  • Mineko Ushiama
  • Noriko Tanabe

Publication venues where Hiromi Sakamoto is frequently published include:

  • Scientific Reports
  • Research Square (Research Square)
  • Communications Biology
  • Genome biology
  • Gastric Cancer

The body of work produced by Hiromi Sakamoto reflects a focus on molecular and genetic mechanisms of cancer, broadly integrating biochemical research and clinical medicine. Their investigation into microRNAs and RNA splicing touches on emerging biomarkers and diagnostic tools, illustrating their role within evolving cancer research methodologies.

Best Publications

  • KIF5B-RET fusions in lung adenocarcinoma.

    Takashi Kohno;Hitoshi Ichikawa;Yasushi Totoki;Kazuki Yasuda

  • Epidermal Growth Factor Receptor Gene Mutations and Increased Copy Numbers Predict Gefitinib Sensitivity in Patients With Recurrent Non–Small-Cell Lung Cancer

    Toshimi Takano;Yuichiro Ohe;Hiromi Sakamoto;Koji Tsuta

  • Identification of genes upregulated in ALK-positive and EGFR/KRAS/ALK-negative lung adenocarcinomas.

    Hirokazu Okayama;Takashi Kohno;Yuko Ishii;Yoko Shimada

  • Genetic variation in PSCA is associated with susceptibility to diffuse-type gastric cancer.

    Hiromi Sakamoto;Kimio Yoshimura;Norihisa Saeki

  • cDNA sequence of human transforming gene hst and identification of the coding sequence required for transforming activity.

    Masanori Taira;Teruhiko Yoshida;Kiyoshi Miyagawa;Hiromi Sakamoto

  • K-sam, an amplified gene in stomach cancer, is a member of the heparin-binding growth factor receptor genes.

    Yutaka Hattori;Hiroki Odagiri;Hiroshi Nakatani;Kiyoshi Miyagawa

  • Transforming gene from human stomach cancers and a noncancerous portion of stomach mucosa.

    Hiromi Sakamoto;Midori Mori;Masanori Taira;Teruhiko Yoshida

  • Genomic sequence of hst, a transforming gene encoding a protein homologous to fibroblast growth factors and the int-2-encoded protein.

    Teruhiko Yoshida;Kiyoshi Miyagawa;Hiroki Odagiri;Hiromi Sakamoto

  • High-resolution characterization of a hepatocellular carcinoma genome

    Yasushi Totoki;Kenji Tatsuno;Shogo Yamamoto;Yasuhito Arai

  • Genetic alterations of the c-erbB-2 oncogene occur frequently in tubular adenocarcinoma of the stomach and are often accompanied by amplification of the v-erbA homologue.

    Yokota J;Yamamoto T;Miyajima N;Toyoshima K

  • Novel combination of serum microRNA for detecting breast cancer in the early stage

    Akihiko Shimomura;Sho Shiino;Junpei Kawauchi;Satoko Takizawa

  • Distinctive expression and function of four GSDM family genes (GSDMA-D) in normal and malignant upper gastrointestinal epithelium.

    Norihisa Saeki;Takebumi Usui;Kazuhiko Aoyagi;Dal Ho Kim

  • Integrated extracellular microRNA profiling for ovarian cancer screening

    Akira Yokoi;Juntaro Matsuzaki;Yusuke Yamamoto;Yutaka Yoneoka

  • ZNF384-related fusion genes define a subgroup of childhood B-cell precursor acute lymphoblastic leukemia with a characteristic immunotype

    Shinsuke Hirabayashi;Kentaro Ohki;Kazuhiko Nakabayashi;Hitoshi Ichikawa

  • High incidence of coamplification of hst-1 and int-2 genes in human esophageal carcinomas.

    Toshitaka Tsuda;Eiichi Tahara;Goro Kajiyama;Hiromi Sakamoto

  • Discovery of Aberrant Expression of R-RAS by Cancer-Linked DNA Hypomethylation in Gastric Cancer Using Microarrays

    Michiko Nishigaki;Kazuhiko Aoyagi;Inaho Danjoh;Masahide Fukaya

  • Druggable Oncogene Fusions in Invasive Mucinous Lung Adenocarcinoma

    Takashi Nakaoku;Koji Tsuta;Hitoshi Ichikawa;Kouya Shiraishi

  • Detection of EGFR mutations in archived cytologic specimens of non-small cell lung cancer using high-resolution melting analysis.

    Kiyoaki Nomoto;Koji Tsuta;Toshimi Takano;Tomoya Fukui

  • Frequent and preferential infection of Treponema denticola, Streptococcus mitis, and Streptococcus anginosus in esophageal cancers.

    Michihiro Narikiyo;Chikako Tanabe;Yukishige Yamada;Hiroyasu Igaki

  • Immunohistochemical detection of K-sam protein in stomach cancer.

    Yutaka Hattori;Hiroshi Itoh;Shinya Uchino;Kouichi Hosokawa

Frequent Co-Authors

Teruhiko Yoshida
Teruhiko Yoshida National Cancer Research Institute, UK
Masaaki Terada
Masaaki Terada National Cancer Research Institute, UK
Takashi Sugimura
Takashi Sugimura National Cancer Centre
Takahiro Ochiya
Takahiro Ochiya Tokyo Medical University
Hiroki Sasaki
Hiroki Sasaki National Cancer Centre
Jun Yokota
Jun Yokota National Cancer Centre
Takashi Kohno
Takashi Kohno National Cancer Centre
Koji Tsuta
Koji Tsuta Kansai Medical University
Shoichiro Tsugane
Shoichiro Tsugane International University of Health and Welfare
Yae Kanai
Yae Kanai Keio University

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