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Medicine

D-Index
92
Citations
25276
World Ranking
11454
National Ranking
337

Overview

Yae Kanai is affiliated with Keio University in Japan, where they have conducted extensive research primarily in the fields of Medicine and Biochemistry, Genetics and Molecular Biology. Their work spans a variety of subfields including Molecular Biology, Oncology, Pulmonary and Respiratory Medicine, Surgery, and Cancer Research.

Kanai's research focuses on core topics such as Epigenetics and DNA Methylation, Cancer Genomics and Diagnostics, RNA modifications and cancer, Liver Disease Diagnosis and Treatment, Cancer Immunotherapy and Biomarkers, Bladder and Urothelial Cancer Treatments, and Cancer-related gene regulation.

Notable recent publications by Kanai include:

  • Multi-omic profiling of peritoneal metastases in gastric cancer identifies molecular subtypes and therapeutic vulnerabilities (2021, Nature Cancer)
  • The Japanese Society of Pathology Practical Guidelines on the handling of pathological tissue samples for cancer genomic medicine (2021, Pathology International)
  • Aberrant DNA methylation results in altered gene expression in non-alcoholic steatohepatitis-related hepatocellular carcinomas (2020, Journal of Cancer Research and Clinical Oncology)
  • Stromal metalloproteinases: Crucial contributors to the tumor microenvironment (2020, Pathology International)
  • Epigenetic profile of Japanese supercentenarians: a cross-sectional study (2023, The Lancet Healthy Longevity)

Kanai frequently collaborates with other researchers, among whom the most common co-authors include Eri Arai, Mao Fujimoto, Teruhiko Yoshida, Ying Tian, and Junko Kuramoto. This collaborative pattern reflects a network of scholars active in related biomedical research areas.

Their work has been published repeatedly in several scientific journals with multiple contributions, particularly in:

  • Pathology International
  • Cancer Research
  • Journal of Cancer Research and Clinical Oncology
  • Gastric Cancer
  • Carcinogenesis

Best Publications

  • Immune cell infiltration as an indicator of the immune microenvironment of pancreatic cancer.

    Y Ino;R Yamazaki-Itoh;K Shimada;M Iwasaki

  • Silencing of the E-cadherin invasion-suppressor gene by CpG methylation in human carcinomas.

    Kenta Yoshiura;Yae Kanai;Atsushi Ochiai;Yutaka Shimoyama

  • Cell adhesion system and human cancer morphogenesis

    Setsuo Hirohashi;Yae Kanai

  • FOXP3+ regulatory T cells affect the development and progression of hepatocarcinogenesis

    Noritoshi Kobayashi;Nobuyoshi Hiraoka;Wataru Yamagami;Hidenori Ojima

  • Increased DNA methyltransferase 1 (DNMT1) protein expression correlates significantly with poorer tumor differentiation and frequent DNA hypermethylation of multiple CpG islands in gastric cancers.

    Tsuyoshi Etoh;Yae Kanai;Saori Ushijima;Tohru Nakagawa

  • E-cadherin gene mutations in human gastric carcinoma cell lines.

    Tatsuya Oda;Yae Kanai;Tsukasa Oyama;Kenta Yoshiura

  • A Truncated β-Catenin Disrupts the Interaction between E-Cadherin and α-Catenin: A Cause of Loss of Intercellular Adhesiveness in Human Cancer Cell Lines

    Tsukasa Oyama;Yae Kanai;Atsushi Ochiai;Shingo Akimoto

  • Genetic instability and aberrant DNA methylation in chronic hepatitis and cirrhosis--A comprehensive study of loss of heterozygosity and microsatellite instability at 39 loci and DNA hypermethylation on 8 CpG islands in microdissected specimens from patients with hepatocellular carcinoma.

    Yutaka Kondo;Y. A. E. Kanai;Michiie Sakamoto;Masashi Mizokami

  • Expression of mRNA for DNA methyltransferases and methyl-CpG-binding proteins and DNA methylation status on CpG islands and pericentromeric satellite regions during human hepatocarcinogenesis.

    Yoshimasa Saito;Yoshimasa Saito;Yae Kanai;Michiie Sakamoto;Hidetsugu Saito

  • Intratumoral tertiary lymphoid organ is a favourable prognosticator in patients with pancreatic cancer.

    N Hiraoka;Y Ino;R Yamazaki-Itoh;Y Kanai

  • The E-cadherin gene is silenced by CpG methylation in human hepatocellular carcinomas

    Yae Kanai;Saori Ushijima;Ai Min Hui;Atsushi Ochiai

  • Increased protein expression of DNA methyltransferase (DNMT) 1 is significantly correlated with the malignant potential and poor prognosis of human hepatocellular carcinomas

    Yoshimasa Saito;Yoshimasa Saito;Yae Kanai;Tohru Nakagawa;Michiie Sakamoto

  • MicroRNA-500 as a potential diagnostic marker for hepatocellular carcinoma

    Yusuke Yamamoto;Nobuyoshi Kosaka;Minoru Tanaka;Fumiaki Koizumi

  • Overexpression of a splice variant of DNA methyltransferase 3b, DNMT3b4, associated with DNA hypomethylation on pericentromeric satellite regions during human hepatocarcinogenesis

    Yoshimasa Saito;Yae Kanai;Michiie Sakamoto;Hidetsugu Saito

  • DNA methyltransferase expression and DNA methylation of CPG islands and peri‐centromeric satellite regions in human colorectal and stomach cancers

    Yae Kanai;Saori Ushijima;Yutaka Kondo;Yukihiro Nakanishi

  • Alterations of DNA methylation associated with abnormalities of DNA methyltransferases in human cancers during transition from a precancerous to a malignant state

    Yae Kanai;Setsuo Hirohashi

  • Downregulation and growth inhibitory effect of epithelial-type Krüppel-like transcription factor KLF4, but not KLF5, in bladder cancer.

    Shunsuke Ohnishi;Sumiko Ohnami;Friedrich Laub;Kazunori Aoki

  • c-erbB-2 gene product directly associates with beta-catenin and plakoglobin.

    Yae Kanai;A. Ochiai;T. Shibata;T. Oyama

  • Prognostic significance of tissue factor in pancreatic ductal adenocarcinoma.

    Nobuhiro Nitori;Yoshinori Ino;Yukihiro Nakanishi;Tesshi Yamada

  • c-erbB-2 gene product associates with catenins in human cancer cells

    Atsushi Ochiai;Shingo Akimoto;Yae Kanai;Tatsuhiro Shibata

Frequent Co-Authors

Setsuo Hirohashi
Setsuo Hirohashi National Cancer Research Institute, UK
Michiie Sakamoto
Michiie Sakamoto Keio University
Tomoo Kosuge
Tomoo Kosuge National Cancer Center
Tatsuhiro Shibata
Tatsuhiro Shibata University of Tokyo
Nobuo Yaegashi
Nobuo Yaegashi Tohoku University
Teruhiko Yoshida
Teruhiko Yoshida National Cancer Research Institute, UK
Hiroyuki Aburatani
Hiroyuki Aburatani University of Tokyo
Ikuo Konishi
Ikuo Konishi Kyoto University
Johji Inazawa
Johji Inazawa Tokyo Medical and Dental University

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