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76
Citations
18272
World Ranking
5110
National Ranking
17

Overview

R. Manjunatha Kini is a researcher affiliated with the National University of Singapore. Their work primarily spans the fields of Biochemistry, Genetics, and Molecular Biology, with considerable contributions to Medicine as well. Their research encompasses a broad range of subfields including Molecular Biology, Genetics, Public Health, Environmental and Occupational Health, Infectious Diseases, and Insect Science.

Major research topics covered by Kini include venomous animal envenomation and studies, mosquito-borne diseases and control, viral infections and vectors, ion channel regulation and function, nicotinic acetylcholine receptors study, insect symbiosis and bacterial influences, and biochemical and structural characterization.

The researcher's recent publications include the following notable papers:

  • The Indian cobra reference genome and transcriptome enables comprehensive identification of venom toxins, 2020, Nature Genetics
  • JNK pathway restricts DENV2, ZIKV and CHIKV infection by activating complement and apoptosis in mosquito salivary glands, 2020, PLoS Pathogens
  • Snake venom three-finger toxins and their potential in drug development targeting cardiovascular diseases, 2020, Biochemical Pharmacology
  • Dengue virus infection modifies mosquito blood-feeding behavior to increase transmission to the host, 2022, Proceedings of the National Academy of Sciences
  • Convergent evolution of toxin resistance in animals, 2022, Biological Reviews/Biological Reviews of the Cambridge Philosophical Society

Frequently collaborating with other researchers, Kini has co-authored extensively with colleagues including Cho Yeow Koh, J. Sivaraman, Yu-Keung Mok, Cassandra M. Modahl, and Julien Pompon.

The researcher has published numerous articles in several scientific venues, often contributing to:

  • Toxicon
  • Toxins
  • Protein Science
  • bioRxiv (Cold Spring Harbor Laboratory)
  • Nature Communications

Throughout the career, Kini has focused on multifaceted research bridging molecular mechanisms and applied aspects of venom toxin biology, vector-borne diseases, and associated molecular pathways. Their work addresses complex biological systems involving venomous animals and insect vectors, reflecting an interdisciplinary approach that intersects genetics, molecular biology, and public health domains.

Best Publications

  • Excitement ahead: structure, function and mechanism of snake venom phospholipase A2 enzymes.

    R Manjunatha Kini

  • The king cobra genome reveals dynamic gene evolution and adaptation in the snake venom system

    Freek J. Vonk;Freek J. Vonk;Freek J. Vonk;Nicholas R. Casewell;Nicholas R. Casewell;Christiaan V. Henkel;Alysha M. Heimberg

  • A model to explain the pharmacological effects of snake venom phospholipases A2.

    R.Manjunatha Kini;Herbert J. Evans

  • Molecular Evolution and Phylogeny of Elapid Snake Venom Three-Finger Toxins

    Bryan Grieg Fry;W. Wüster;R. M. Kini;V. Brusic

  • Venom phospholipase A2 enzymes

    R. Manjunatha. Kini

  • Structure, function and evolution of three-finger toxins: Mini proteins with multiple targets

    R. Manjunatha Kini;Robin Doley;Robin Doley

  • Enzymatic toxins from snake venom: structural characterization and mechanism of catalysis.

    Tse Siang Kang;Dessislava Georgieva;Nikolay Genov;Mário T. Murakami

  • Structural domains in venom proteins: evidence that metalloproteinases and nonenzymatic platelet aggregation inhibitors (disintegrins) from snake venoms are derived by proteolysis from a common precursor.

    R.Manjunatha Kini;Herbert J. Evans

  • Anticoagulant proteins from snake venoms: structure, function and mechanism

    R. Manjunatha Kini

  • Characterization of three edema-inducing phospholipase A2 enzymes from habu (Trimeresurus flavoviridis) venom and their interaction with the alkaloid aristolochic acid

    B. Sannanaik Vishwanath;R. Manjunatha Kini;T. Veerabasappa Gowda

  • Structure-function relationships and mechanism of anticoagulant phospholipase A2 enzymes from snake venoms

    R. Manjunatha Kini

  • Denmotoxin, a three-finger toxin from the colubrid snake Boiga dendrophila (Mangrove Catsnake) with bird-specific activity.

    Joanna Pawlak;Stephen P. Mackessy;Bryan G. Fry;Madhav Bhatia

  • From snake venom toxins to therapeutics – Cardiovascular examples

    Cho Yeow Koh;R. Manjunatha Kini;R. Manjunatha Kini

  • Irditoxin, a novel covalently linked heterodimeric three-finger toxin with high taxon-specific neurotoxicity

    Joanna Pawlak;Stephen P. Mackessy;Nicole M. Sixberry;Enrico A. Stura

  • Serine proteases affecting blood coagulation and fibrinolysis from snake venoms.

    R. Manjunatha Kini

  • Accelerated Evolution and Molecular Surface of Venom Phospholipase A2 Enzymes

    R. Manjunatha Kini;Yiu Man Chan

  • Molecular moulds with multiple missions: functional sites in three-finger toxins.

    R Manjunatha Kini

  • Isolation of a Neurotoxin (α-colubritoxin) from a Nonvenomous Colubrid: Evidence for Early Origin of Venom in Snakes

    Bryan G. Fry;Natalie G. Lumsden;Wolfgang Wüster;Janith C. Wickramaratna

  • A common cytolytic region in myotoxins, hemolysins, cardiotoxins and antibacterial peptides.

    R. Manjunatha Kini;Herbert J. Evans

  • Antimicrobial activity of omwaprin, a new member of the waprin family of snake venom proteins

    Dileep G. Nair;Bryan G. Fry;Bryan G. Fry;Paul Alewood;Prakash P. Kumar

Frequent Co-Authors

Bryan G. Fry
Bryan G. Fry University of Queensland
Suresh Valiyaveettil
Suresh Valiyaveettil National University of Singapore
Stephen P. Mackessy
Stephen P. Mackessy University of Northern Colorado
Sadaaki Iwanaga
Sadaaki Iwanaga Kyushu University
Takashi Morita
Takashi Morita Meiji Pharmaceutical University
Maxey C. M. Chung
Maxey C. M. Chung National University of Singapore
Kandiah Jeyaseelan
Kandiah Jeyaseelan National University of Singapore
Wilfried M. A. Niessen
Wilfried M. A. Niessen Vrije Universiteit Amsterdam
Govert W. Somsen
Govert W. Somsen Vrije Universiteit Amsterdam
Prakash P. Kumar
Prakash P. Kumar National University of Singapore

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