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Biology and Biochemistry

D-Index
58
Citations
11487
World Ranking
13230
National Ranking
49

Overview

Jeak Ling Ding is a researcher affiliated with the National University of Singapore in Singapore. Their work primarily lies at the intersection of biochemistry, genetics, molecular biology, immunology, microbiology, and medicine, reflecting a multidisciplinary approach to biomedical sciences.

Their research extensively covers the fields of immunology, molecular biology, oncology, cell biology, and epidemiology.

Key topics explored by Ding include:

  • Ubiquitin and proteasome pathways
  • Immune cell function and interaction
  • Peptidase inhibition and analysis
  • Autophagy in disease and therapy
  • Immune cells in cancer
  • Cancer-related molecular pathways
  • Protein degradation and inhibitors

Recent publications by Ding span multiple high-impact journals and cover various aspects of immune function and cancer biology. Notable papers include:

  • "Eomes Expression Defines Group 1 Innate Lymphoid Cells During Metastasis in Human and Mouse" (2020, Frontiers in Immunology)
  • "E2-E3 ubiquitin enzyme pairing - partnership in provoking or mitigating cancers" (2022, Biochimica et Biophysica Acta (BBA) - Reviews on Cancer)
  • "NK Cells in a Tug-of-War With Cancer: The Roles of Transcription Factors and Cytoskeleton" (2021, Frontiers in Immunology)
  • "Human FBXL8 Is a Novel E3 Ligase Which Promotes BRCA Metastasis by Stimulating Pro-Tumorigenic Cytokines and Inhibiting Tumor Suppressors" (2020, Cancers)
  • "A Novel Signature of CCNF-Associated E3 Ligases Collaborate and Counter Each Other in Breast Cancer" (2021, Cancers)

These publications illustrate an ongoing focus on the mechanisms by which ubiquitin ligases and immune cells interact in the context of cancer metastasis and tumor microenvironment modulation.

Ding has collaborated frequently with several researchers in related fields, including:

  • Shu-Chun Chang
  • Chin-Sheng Hung
  • Bo-Xiang Zhang
  • Darren Chen Pei Wong
  • Wayne Hsu

Their work has been published repeatedly in journals and venues such as:

  • Frontiers in Immunology
  • Biochimica et Biophysica Acta (BBA) - Reviews on Cancer
  • Cancers
  • bioRxiv (Cold Spring Harbor Laboratory)
  • Science Advances

Best Publications

  • Natural Antibodies Bridge Innate and Adaptive Immunity

    Saswati Panda;Jeak L. Ding

  • Iron-withholding strategy in innate immunity.

    Sek Tong Ong;Jason Zhe Shan Ho;Bow Ho;Jeak Ling Ding

  • ANGPTL4 modulates vascular junction integrity by integrin signaling and disruption of intercellular VE-cadherin and claudin-5 clusters.

    Royston-Luke Huang;Ziqiang Teo;Han Chung Chong;Pengcheng Zhu

  • Angiopoietin-like 4 Protein Elevates the Prosurvival Intracellular O2-:H2O2 Ratio and Confers Anoikis Resistance to Tumors

    Pengcheng Zhu;Ming Jie Tan;Royston Luke Huang;Chek Kun Tan

  • The ancient origin of the complement system

    Yong Zhu;Saravanan Thangamani;Bow Ho;Jeak Ling Ding

  • Respiratory protein-generated reactive oxygen species as an antimicrobial strategy.

    Naxin Jiang;Nguan Soon Tan;Bow Ho;Jeak Ling Ding

  • GPR41 and GPR43 in Obesity and inflammation - Protective or Causative?

    Zhiwei Ang;Jeak Ling Ding

  • De Novo Design of Potent Antimicrobial Peptides

    V. Frecer;B. Ho;J. L. Ding

  • Mechanically alloyed nanocomposite magnets (invited)

    Paul Mccormick;W.F. Miao;P.A.I. Smith;J. Ding

  • Cationic supramolecules composed of multiple oligoethylenimine-grafted β-cyclodextrins threaded on a polymer chain for efficient gene delivery

    Jun Li;Chuan Yang;Hongzhe Li;Xin Wang

  • Receptor-Ligand Interaction between Vitellogenin Receptor (VtgR) and Vitellogenin (Vtg), Implications on Low Density Lipoprotein Receptor and Apolipoprotein B/E THE FIRST THREE LIGAND-BINDING REPEATS OF VTGR INTERACT WITH THE AMINO-TERMINAL REGION OF VTG

    Ankang Li;Murali Sadasivam;Jeak Ling Ding

  • High frequency complex permeability of iron particles in a nonmagnetic matrix

    L. Z. Wu;J. Ding;H. B. Jiang;C. P. Neo

  • A new era in pyrogen testing.

    Jeak L. Ding;Bow Ho

  • Angiopoietin-like 4 interacts with matrix proteins to modulate wound healing.

    Yan Yih Goh;Mintu Pal;Han Chung Chong;Pengcheng Zhu

  • C-reactive protein collaborates with plasma lectins to boost immune response against bacteria

    Patricia M L Ng;Agnès Le Saux;Chia M Lee;Nguan S Tan

  • SARM inhibits both TRIF- and MyD88-mediated AP-1 activation.

    Jun Peng;Quan Yuan;Bin Lin;Porkodi Panneerselvam

  • Angiopoietin-Like 4 Interacts with Integrins β1 and β5 to Modulate Keratinocyte Migration

    Yan Yih Goh;Mintu Pal;Han Chung Chong;Pengcheng Zhu

  • TLR cross-talk confers specificity to innate immunity.

    Rebecca S. T. Tan;Bow Ho;Bernard P. Leung;Jeak L. Ding

  • Atomic force microscopy study of the antimicrobial action of Sushi peptides on Gram negative bacteria.

    A. Li;P.Y. Lee;B. Ho;J.L. Ding;J.L. Ding

  • Determination of critical micelle concentrations and aggregation numbers by fluorescence correlation spectroscopy: aggregation of a lipopolysaccharide.

    Lanlan Yu;Minyi Tan;Bow Ho;Jeak Ling Ding

Frequent Co-Authors

Nguan Soon Tan
Nguan Soon Tan Nanyang Technological University
Robert Street
Robert Street University of Western Australia
Jiabao Yi
Jiabao Yi University of Newcastle Australia
Jingsheng Chen
Jingsheng Chen National University of Singapore
Paul Mccormick
Paul Mccormick Columbia University
Wee Joo Chng
Wee Joo Chng National University of Singapore
Jian-Ping Wang
Jian-Ping Wang University of Minnesota
Timothy J. Peters
Timothy J. Peters University of Bristol
Tun Seng Herng
Tun Seng Herng National University of Singapore

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