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Jianzhu Chen

Jianzhu Chen

D-Index & Metrics

Microbiology

D-Index
87
Citations
27726
World Ranking
794
National Ranking
366

Overview

Jianzhu Chen is affiliated with MIT in the United States and has made contributions primarily in the fields of Medicine, Immunology and Microbiology, and Biochemistry, Genetics and Molecular Biology. Their research portfolio spans key subfields such as Immunology, Molecular Biology, Oncology, Infectious Diseases, and Public Health, Environmental and Occupational Health.

The scientist's work focuses on topics including CAR-T cell therapy research, Immune Cell Function and Interaction, Immunotherapy and Immune Responses, T-cell and B-cell Immunology, Immune cells in cancer, Mosquito-borne diseases and control, and RNA Interference and Gene Delivery.

Jianzhu Chen has published extensively in several notable venues. Frequent publication outlets include bioRxiv (Cold Spring Harbor Laboratory), Nature Communications, Frontiers in Immunology, Science Advances, and ACS Infectious Diseases.

Among the recent papers authored by or involving Jianzhu Chen are:

  • CAR-NK cells: A promising cellular immunotherapy for cancer (2020) published in EBioMedicine
  • High-throughput phenotypic screen and transcriptional analysis identify new compounds and targets for macrophage reprogramming (2021) published in Nature Communications
  • Memory-like NK cells armed with a neoepitope-specific CAR exhibit potent activity against NPM1 mutated acute myeloid leukemia (2022) published in Proceedings of the National Academy of Sciences
  • In situ cancer vaccination using lipidoid nanoparticles (2021) published in Science Advances
  • Current Developments and Challenges of mRNA Vaccines (2022) published in Annual Review of Biomedical Engineering

The scientist collaborates frequently with a group of co-authors, including Rizwan Romee, Guangan Hu, Mubin Tarannum, James Dongjoo Ham, and Jerome Ritz. The number of joint publications with these colleagues ranges from eight to fifteen.

Best Publications

  • Interleukin-2 receptor α chain regulates the size and content of the peripheral lymphoid compartment

    Dennis M. Willerford;Jianzhu Chen;Judith A. Ferry;Laurie Davidson

  • Densely Interconnected Transcriptional Circuits Control Cell States in Human Hematopoiesis

    Noa Novershtern;Noa Novershtern;Noa Novershtern;Aravind Subramanian;Lee N. Lawton;Raymond H. Mak

  • RNA interference of influenza virus production by directly targeting mRNA for degradation and indirectly inhibiting all viral RNA transcription

    Qing Ge;Michael T. McManus;Tam Nguyen;Ching-Hung Shen

  • CAR-NK cells: A promising cellular immunotherapy for cancer

    Guozhu Xie;Han Dong;Yong Liang;James Dongjoo Ham

  • B-1 and B-2 Cell–Derived Immunoglobulin M Antibodies Are Nonredundant Components of the Protective Response to Influenza Virus Infection

    Nicole Baumgarth;Ometa C. Herman;Gina C. Jager;Lorena E. Brown

  • Homeostasis-Stimulated Proliferation Drives Naive T Cells to Differentiate Directly into Memory T Cells

    Bryan K. Cho;Varada P. Rao;Qing Ge;Herman N. Eisen

  • A Critical Role of Natural Immunoglobulin M in Immediate Defense Against Systemic Bacterial Infection

    Marianne Boes;Andrey P. Prodeus;Tara Schmidt;Michael C. Carroll

  • Immunoglobulin gene rearrangement in B cell deficient mice generated by targeted deletion of the JH locus.

    Jianzhu Chen;Mary Trounstine;Frederick W. Alt;Faith Young

  • Inhibition of influenza virus production in virus-infected mice by RNA interference

    Qing Ge;Lily Filip;Ailin Bai;Tam Nguyen

  • Gene silencing using micro-RNA designed hairpins.

    Michael T. McMANUS;Christian P. Petersen;Brian B. Haines;Jianzhu Chen

  • T-cell engagement of dendritic cells rapidly rearranges MHC class II transport

    Marianne Boes;Jan Cerny;Jan Cerny;Ramiro Massol;Marjolein Op den Brouw

  • RAG-2-deficient blastocyst complementation: an assay of gene function in lymphocyte development.

    Jianzhu Chen;Russell Lansford;Valerie Stewart;Faith Young

  • Full deacylation of polyethylenimine dramatically boosts its gene delivery efficiency and specificity to mouse lung

    Mini Thomas;James J. Lu;Qing Ge;Chengcheng Zhang

  • Accelerated development of IgG autoantibodies and autoimmune disease in the absence of secreted IgM

    Marianne Boes;Tara Schmidt;Kathrin Linkemann;Britte C. Beaudette

  • A B Cell-Based Sensor for Rapid Identification of Pathogens

    Todd H. Rider;Martha S. Petrovick;Frances E. Nargi;James D. Harper

  • Enhanced B-1 cell development, but impaired IgG antibody responses in mice deficient in secreted IgM.

    Marianne Boes;Christine Esau;Michael B. Fischer;Tara Schmidt

  • In vivo genome editing and organoid transplantation models of colorectal cancer and metastasis

    Jatin Roper;Jatin Roper;Tuomas Tammela;Naniye Malli Cetinbas;Adam Akkad

  • Polymeric coatings that inactivate both influenza virus and pathogenic bacteria

    Jayanta Haldar;Deqiang An;Luis Álvarez de Cienfuegos;Jianzhu Chen

  • Small Interfering RNA-Mediated Gene Silencing in T Lymphocytes

    Michael T. McManus;Brian B. Haines;Christopher P. Dillon;Charles E. Whitehurst

  • B cell development in mice that lack one or both immunoglobulin kappa light chain genes.

    Jianzhu Chen;M. Trounstine;C. Kurahara;F. Young

  • Cross-linked small polyethylenimines: while still nontoxic, deliver DNA efficiently to mammalian cells in vitro and in vivo.

    Mini Thomas;Qing Ge;James J. Lu;Jianzhu Chen

Frequent Co-Authors

Eng Eong Ooi
Eng Eong Ooi National University of Singapore
Frederick W. Alt
Frederick W. Alt Boston Children's Hospital
Peter R. Preiser
Peter R. Preiser Nanyang Technological University
Vincent T. K. Chow
Vincent T. K. Chow National University of Singapore
Jeak Ling Ding
Jeak Ling Ding National University of Singapore
Jerry Kok Yen Chan
Jerry Kok Yen Chan National University of Singapore

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