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Donald S. Kirkpatrick

Donald S. Kirkpatrick

D-Index & Metrics

Biology and Biochemistry

D-Index
60
Citations
14271
World Ranking
11868
National Ranking
5100

Overview

Donald S. Kirkpatrick is affiliated with Genentech in the United States. Their research primarily spans the fields of Biochemistry, Genetics and Molecular Biology, with contributions also to Medicine. Their subfields of expertise include Molecular Biology, Immunology, Oncology, Epidemiology, and Genetics.

The scientist's work covers several main topics, including:

  • Ubiquitin and proteasome pathways
  • Protein Degradation and Inhibitors
  • Immune cells in cancer
  • Peptidase Inhibition and Analysis
  • Autophagy in Disease and Therapy
  • RNA modifications and cancer
  • Melanoma and MAPK Pathways

Kirkpatrick's recent published papers feature research in various high-impact journals:

  • The Indian cobra reference genome and transcriptome enables comprehensive identification of venom toxins, 2020, Nature Genetics
  • Ubiquitin Ligase COP1 Suppresses Neuroinflammation by Degrading c/EBPβ in Microglia, 2020, Cell
  • Dynamic Regulation of Mitochondrial Import by the Ubiquitin System, 2020, Molecular Cell
  • Global site-specific neddylation profiling reveals that NEDDylated cofilin regulates actin dynamics, 2020, Nature Structural & Molecular Biology
  • PIKES Analysis Reveals Response to Degraders and Key Regulatory Mechanisms of the CRL4 Network, 2020, Molecular Cell

Frequent co-authors collaborating with Kirkpatrick include:

  • Christopher M. Rose
  • Trent Hinkle
  • Erik Verschueren
  • Lilian Phu
  • Shiva Malek

The most common venues for publishing their work are:

  • Molecular Cell
  • Nature Communications
  • bioRxiv (Cold Spring Harbor Laboratory)
  • Nature Structural & Molecular Biology
  • Cell Reports

Best Publications

  • The mitochondrial deubiquitinase USP30 opposes parkin-mediated mitophagy

    Baris Bingol;Joy S. Tea;Lilian Phu;Mike Reichelt

  • The absolute quantification strategy: a general procedure for the quantification of proteins and post-translational modifications

    Donald S. Kirkpatrick;Scott A. Gerber;Steven P. Gygi

  • Differential regulation of EGF receptor internalization and degradation by multiubiquitination within the kinase domain.

    Fangtian Huang;Donald Kirkpatrick;Xuejun Jiang;Steven Gygi

  • Ubiquitin Chain Editing Revealed by Polyubiquitin Linkage-Specific Antibodies

    Kim Newton;Marissa L. Matsumoto;Ingrid E. Wertz;Donald S. Kirkpatrick

  • Lysine 63-linked ubiquitination promotes the formation and autophagic clearance of protein inclusions associated with neurodegenerative diseases

    Jeanne M M Tan;Esther S P Wong;Donald S. Kirkpatrick;Olga Pletnikova

  • Quantitative analysis of in vitro ubiquitinated cyclin B1 reveals complex chain topology

    Donald S. Kirkpatrick;Nathaniel A. Hathaway;John Hanna;Suzanne Elsasser

  • K11-Linked Polyubiquitination in Cell Cycle Control Revealed by a K11 Linkage-Specific Antibody

    Marissa L. Matsumoto;Katherine E. Wickliffe;Ken C. Dong;Christine Yu

  • Loss of the Tumor Suppressor BAP1 Causes Myeloid Transformation

    Anwesha Dey;Dhaya Seshasayee;Rajkumar Noubade;Dorothy M. French

  • Deubiquitinating Enzyme Ubp6 Functions Noncatalytically to Delay Proteasomal Degradation

    John Hanna;Nathaniel A. Hathaway;Yoshiko Tone;Bernat Crosas;Bernat Crosas

  • Primary cilia membrane assembly is initiated by Rab11 and transport protein particle II (TRAPPII) complex-dependent trafficking of Rabin8 to the centrosome

    Christopher J. Westlake;Lisa M. Baye;Maxence V. Nachury;Kevin J. Wright

  • c‐IAP1 and UbcH5 promote K11‐linked polyubiquitination of RIP1 in TNF signalling

    Jasmin N Dynek;Tatiana Goncharov;Erin C Dueber;Anna V Fedorova

  • Ser1292 autophosphorylation is an indicator of LRRK2 kinase activity and contributes to the cellular effects of PD mutations.

    Zejuan Sheng;Shuo Zhang;Daisy Bustos;Tracy Kleinheinz

  • Ubiquitin chains are remodeled at the proteasome by opposing ubiquitin ligase and deubiquitinating activities.

    Bernat Crosas;John Hanna;Donald S. Kirkpatrick;Dan Phoebe Zhang

  • USP30 and parkin homeostatically regulate atypical ubiquitin chains on mitochondria

    Christian N. Cunningham;Joshua M. Baughman;Lilian Phu;Joy S. Tea

  • Weighing in on ubiquitin: the expanding role of mass-spectrometry-based proteomics

    Donald S. Kirkpatrick;Carilee Denison;Steven P. Gygi

  • Discovery of Novel Blood-Brain Barrier Targets to Enhance Brain Uptake of Therapeutic Antibodies

    Y. Joy Yu Zuchero;Xiaocheng Chen;Nga Bien-Ly;Daniela Bumbaca

  • Ubiquitin Ligase RNF146 Regulates Tankyrase and Axin to Promote Wnt Signaling

    Marinella G. Callow;Hoanh Tran;Lilian Phu;Ted Lau

  • Ubiquitin Binding to A20 ZnF4 Is Required for Modulation of NF-κB Signaling

    Ivan Bosanac;Ingrid E. Wertz;Borlan Pan;Christine Yu

  • Overcoming EMT-associated resistance to anti-cancer drugs via Src/FAK pathway inhibition

    Catherine Wilson;Katrina Nicholes;Daisy Bustos;Eva Lin

  • OTULIN limits cell death and inflammation by deubiquitinating LUBAC

    Klaus Heger;Katherine E Wickliffe;Ada Ndoja;Juan Zhang

Frequent Co-Authors

Steven P. Gygi
Steven P. Gygi Harvard University
Domagoj Vucic
Domagoj Vucic Genentech
Daniel Finley
Daniel Finley Harvard University
Zora Modrusan
Zora Modrusan Genentech
Kim Newton
Kim Newton Genentech
David Arnott
David Arnott Genentech
Morgan Sheng
Morgan Sheng Broad Institute

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