What is she best known for?
The fields of study she is best known for:
Lori Friedman focuses on Cancer, Cancer research, PI3K/AKT/mTOR pathway, Breast cancer and Kinase.
Her research integrates issues of Melanoma and Pharmacology in her study of Cancer.
In her study, which falls under the umbrella issue of Cancer research, Chromatid is strongly linked to DNA repair.
Lori Friedman combines subjects such as Cancer cell, Protein kinase B and In vivo with her study of PI3K/AKT/mTOR pathway.
Her Breast cancer study also includes
- Ovarian cancer, which have a strong connection to Mutation, Gene, Locus and Tumor suppressor gene,
- Gene mutation which connect with Male breast cancer.
Her research in Kinase intersects with topics in Signal transduction, Immunology and Phosphoinositide 3-kinase.
Her most cited work include:
- RAF inhibitors prime wild-type RAF to activate the MAPK pathway and enhance growth (1224 citations)
- Systematic generation of high-resolution deletion coverage of the Drosophila melanogaster genome (689 citations)
- Ligand-Independent HER2/HER3/PI3K Complex Is Disrupted by Trastuzumab and Is Effectively Inhibited by the PI3K Inhibitor GDC-0941 (624 citations)
What are the main themes of her work throughout her whole career to date?
Her primary scientific interests are in Cancer research, PI3K/AKT/mTOR pathway, Gene, Genetics and Cancer.
Her Cancer research study integrates concerns from other disciplines, such as Mutant, Immunology, Breast cancer, Estrogen receptor and Kinase.
The Kinase study combines topics in areas such as Carcinogenesis and Signal transduction.
Her studies in PI3K/AKT/mTOR pathway integrate themes in fields like Protein kinase B, Pharmacology and Cell growth.
Her Gene research includes elements of Molecular biology and Function.
Cell cycle is closely connected to Clonogenic assay in her research, which is encompassed under the umbrella topic of Cancer.
She most often published in these fields:
- Cancer research (42.42%)
- PI3K/AKT/mTOR pathway (39.39%)
- Gene (28.03%)
What were the highlights of her more recent work (between 2015-2021)?
- Cancer research (42.42%)
- PI3K/AKT/mTOR pathway (39.39%)
- Cancer (24.24%)
In recent papers she was focusing on the following fields of study:
Lori Friedman spends much of her time researching Cancer research, PI3K/AKT/mTOR pathway, Cancer, Breast cancer and Estrogen receptor.
Her Cancer research study incorporates themes from Cell growth, Palbociclib, Fulvestrant, Kinase and In vivo.
Her Kinase research focuses on MAPK/ERK pathway in particular.
Her PI3K/AKT/mTOR pathway study combines topics from a wide range of disciplines, such as Protein kinase B, CD44 and Mutant.
Her Cancer research is multidisciplinary, incorporating perspectives in Pi, Glucocorticoid receptor, Biomarker and Immune tolerance.
She interconnects Dual inhibition and Oncology in the investigation of issues within Breast cancer.
Between 2015 and 2021, her most popular works were:
- Double PIK3CA mutations in cis increase oncogenicity and sensitivity to PI3Kα inhibitors. (63 citations)
- The selective estrogen receptor downregulator GDC-0810 is efficacious in diverse models of ER+ breast cancer (61 citations)
- The Rational Design of Selective Benzoxazepin Inhibitors of the α-Isoform of Phosphoinositide 3-Kinase Culminating in the Identification of (S)-2-((2-(1-Isopropyl-1H-1,2,4-triazol-5-yl)-5,6-dihydrobenzo[f]imidazo[1,2-d][1,4]oxazepin-9-yl)oxy)propanamide (GDC-0326). (47 citations)
In her most recent research, the most cited papers focused on:
Lori Friedman mainly investigates Cancer research, PI3K/AKT/mTOR pathway, Kinase, Cancer and Breast cancer.
The study incorporates disciplines such as Fulvestrant and Immunology in addition to Cancer research.
The concepts of her PI3K/AKT/mTOR pathway study are interwoven with issues in Protein kinase B, Cell growth and Kinase activity.
Her work carried out in the field of Kinase brings together such families of science as Propanamide, Isozyme and Phosphoinositide 3-kinase.
Her Cancer research includes themes of Pi and Immune tolerance.
Her research on Breast cancer frequently connects to adjacent areas such as Pharmacology.
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