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Daniel F. Ortwine

Daniel F. Ortwine

D-Index & Metrics

Discipline name D-Index World Ranking Current World Ranking National Ranking Current National Ranking Publications Citations
Chemistry 41 17786 16086 4340 3575 110 5782

Daniel F. Ortwine publications per year

The chart shows the history of publications by Daniel F. Ortwine between 1977 and 2024, highlighting the no. of papers published in each year and offering an overview of the publication velocity of this scholar. Daniel F. Ortwine published across 48 years, from 1977 to 2024, averaging 2.5 papers a year. Output peaked at 9 publications in 2016. 3 of the 120 publications appeared in the last two years.

No. of publications
2 4 6 8
Bar chart. Horizontal axis: year, 1977 to 2024. Vertical axis: number of publications, 0 to 9. Peak 9 publications in 2016. 1977: 2 publications 1978: 0 publications 1979: 0 publications 1980: 0 publications 1981: 1 publication 1982: 0 publications 1983: 2 publications 1984: 2 publications 1985: 2 publications 1986: 2 publications 1987: 2 publications 1988: 2 publications 1989: 3 publications 1990: 4 publications 1991: 5 publications 1992: 3 publications 1993: 4 publications 1994: 2 publications 1995: 3 publications 1996: 5 publications 1997: 0 publications 1998: 0 publications 1999: 5 publications 2000: 3 publications 2001: 0 publications 2002: 0 publications 2003: 2 publications 2004: 1 publication 2005: 0 publications 2006: 1 publication 2007: 2 publications 2008: 2 publications 2009: 0 publications 2010: 1 publication 2011: 2 publications 2012: 2 publications 2013: 7 publications 2014: 3 publications 2015: 5 publications 2016: 9 publications 2017: 4 publications 2018: 5 publications 2019: 9 publications 2020: 1 publication 2021: 6 publications 2022: 3 publications 2023: 1 publication 2024: 2 publications
1977 2024

120 publications in total across all disciplines

View publications per year as a table
Daniel F. Ortwine: publications per year, 1977 to 2024
Year Publications
1977 2
1978 0
1979 0
1980 0
1981 1
1982 0
1983 2
1984 2
1985 2
1986 2
1987 2
1988 2
1989 3
1990 4
1991 5
1992 3
1993 4
1994 2
1995 3
1996 5
1997 0
1998 0
1999 5
2000 3
2001 0
2002 0
2003 2
2004 1
2005 0
2006 1
2007 2
2008 2
2009 0
2010 1
2011 2
2012 2
2013 7
2014 3
2015 5
2016 9
2017 4
2018 5
2019 9
2020 1
2021 6
2022 3
2023 1
2024 2
Total 120
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Daniel F. Ortwine publication distribution in Chemistry in 2026

The chart shows the distribution of publications by all Research.com ranked scientists in the field of Chemistry in 2026. The highlighted bar marks where Daniel F. Ortwine sits on this spectrum.

No. of scientists
250 500 750 1,000 1,250
Bar chart with 63 bars. Horizontal axis: publications, 61–80 to 1,295+. Vertical axis: number of scientists, 0 to 1,350. Most scientists, 1,350, have 161–180 publications. The last bar groups every scientist with 1,295 publications or more. The highlighted bar, 101–120 publications, is where this scientist sits. 61–80 publications: 66 scientists 81–100 publications: 302 scientists 101–120 publications: 623 scientists 121–140 publications: 918 scientists 141–160 publications: 1,218 scientists 161–180 publications: 1,350 scientists 181–200 publications: 1,344 scientists 201–220 publications: 1,281 scientists 221–240 publications: 1,216 scientists 241–260 publications: 1,100 scientists 261–280 publications: 979 scientists 281–300 publications: 939 scientists 301–320 publications: 764 scientists 321–340 publications: 643 scientists 341–360 publications: 628 scientists 361–380 publications: 522 scientists 381–400 publications: 459 scientists 401–420 publications: 397 scientists 421–440 publications: 327 scientists 441–460 publications: 270 scientists 461–480 publications: 265 scientists 481–500 publications: 252 scientists 501–520 publications: 201 scientists 521–540 publications: 185 scientists 541–560 publications: 148 scientists 561–580 publications: 148 scientists 581–600 publications: 132 scientists 601–620 publications: 114 scientists 621–640 publications: 104 scientists 641–660 publications: 91 scientists 661–680 publications: 92 scientists 681–700 publications: 73 scientists 701–720 publications: 57 scientists 721–740 publications: 54 scientists 741–760 publications: 67 scientists 761–780 publications: 45 scientists 781–800 publications: 46 scientists 801–820 publications: 39 scientists 821–840 publications: 32 scientists 841–860 publications: 36 scientists 861–880 publications: 29 scientists 881–900 publications: 26 scientists 901–920 publications: 24 scientists 921–940 publications: 14 scientists 941–960 publications: 23 scientists 961–980 publications: 28 scientists 981–1,000 publications: 15 scientists 1,001–1,020 publications: 29 scientists 1,021–1,040 publications: 12 scientists 1,041–1,060 publications: 19 scientists 1,061–1,080 publications: 12 scientists 1,081–1,100 publications: 6 scientists 1,101–1,120 publications: 8 scientists 1,121–1,140 publications: 12 scientists 1,141–1,160 publications: 5 scientists 1,161–1,180 publications: 6 scientists 1,181–1,200 publications: 14 scientists 1,201–1,220 publications: 7 scientists 1,221–1,240 publications: 2 scientists 1,241–1,260 publications: 6 scientists 1,261–1,280 publications: 4 scientists 1,281–1,294 publications: 6 scientists 1,295+ publications: 100 scientists
61–80 publications 1,295+

This scientist: 110 publications — 4th percentile

4% of scientists in this discipline score the same or lower.

The last bar groups every scientist with 1,295 publications or more.

View publications distribution as a table
Number of Chemistry scientists by publication count, Research.com 2026 ranking edition. Based on 17,934 ranked scientists.
Publications Scientists This scientist
61–80 66
81–100 302
101–120 623 110
121–140 918
141–160 1,218
161–180 1,350
181–200 1,344
201–220 1,281
221–240 1,216
241–260 1,100
261–280 979
281–300 939
301–320 764
321–340 643
341–360 628
361–380 522
381–400 459
401–420 397
421–440 327
441–460 270
461–480 265
481–500 252
501–520 201
521–540 185
541–560 148
561–580 148
581–600 132
601–620 114
621–640 104
641–660 91
661–680 92
681–700 73
701–720 57
721–740 54
741–760 67
761–780 45
781–800 46
801–820 39
821–840 32
841–860 36
861–880 29
881–900 26
901–920 24
921–940 14
941–960 23
961–980 28
981–1,000 15
1,001–1,020 29
1,021–1,040 12
1,041–1,060 19
1,061–1,080 12
1,081–1,100 6
1,101–1,120 8
1,121–1,140 12
1,141–1,160 5
1,161–1,180 6
1,181–1,200 14
1,201–1,220 7
1,221–1,240 2
1,241–1,260 6
1,261–1,280 4
1,281–1,294 6
1,295+ 100
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Daniel F. Ortwine D-index placement in Chemistry in 2026

The chart shows the D-index (discipline H-index) distribution of Chemistry scientists ranked by Research.com in 2026. The highlighted bar marks where Daniel F. Ortwine sits on this spectrum.

No. of scientists
250 500 750 1,000
Bar chart with 61 bars. Horizontal axis: D-Index, 40–41 to 159+. Vertical axis: number of scientists, 0 to 1,051. Most scientists, 1,051, have 56–57 D-Index. The last bar groups every scientist with 159 D-Index or more. The highlighted bar, 40–41 D-Index, is where this scientist sits. 40–41 D-Index: 289 scientists 42–43 D-Index: 612 scientists 44–45 D-Index: 808 scientists 46–47 D-Index: 776 scientists 48–49 D-Index: 835 scientists 50–51 D-Index: 861 scientists 52–53 D-Index: 872 scientists 54–55 D-Index: 933 scientists 56–57 D-Index: 1,051 scientists 58–59 D-Index: 930 scientists 60–61 D-Index: 882 scientists 62–63 D-Index: 834 scientists 64–65 D-Index: 731 scientists 66–67 D-Index: 775 scientists 68–69 D-Index: 683 scientists 70–71 D-Index: 646 scientists 72–73 D-Index: 561 scientists 74–75 D-Index: 501 scientists 76–77 D-Index: 437 scientists 78–79 D-Index: 388 scientists 80–81 D-Index: 354 scientists 82–83 D-Index: 292 scientists 84–85 D-Index: 275 scientists 86–87 D-Index: 254 scientists 88–89 D-Index: 235 scientists 90–91 D-Index: 185 scientists 92–93 D-Index: 192 scientists 94–95 D-Index: 155 scientists 96–97 D-Index: 163 scientists 98–99 D-Index: 125 scientists 100–101 D-Index: 105 scientists 102–103 D-Index: 105 scientists 104–105 D-Index: 112 scientists 106–107 D-Index: 88 scientists 108–109 D-Index: 68 scientists 110–111 D-Index: 69 scientists 112–113 D-Index: 65 scientists 114–115 D-Index: 79 scientists 116–117 D-Index: 61 scientists 118–119 D-Index: 44 scientists 120–121 D-Index: 37 scientists 122–123 D-Index: 40 scientists 124–125 D-Index: 33 scientists 126–127 D-Index: 26 scientists 128–129 D-Index: 34 scientists 130–131 D-Index: 35 scientists 132–133 D-Index: 25 scientists 134–135 D-Index: 27 scientists 136–137 D-Index: 17 scientists 138–139 D-Index: 16 scientists 140–141 D-Index: 20 scientists 142–143 D-Index: 20 scientists 144–145 D-Index: 15 scientists 146–147 D-Index: 9 scientists 148–149 D-Index: 9 scientists 150–151 D-Index: 16 scientists 152–153 D-Index: 11 scientists 154–155 D-Index: 9 scientists 156–157 D-Index: 3 scientists 158 D-Index: 3 scientists 159+ D-Index: 98 scientists
40–41 D-Index 159+

This scientist: 41 D-Index — 2nd percentile

2% of scientists in this discipline score the same or lower.

The last bar groups every scientist with 159 D-Index or more.

View D-Index distribution as a table
Number of Chemistry scientists by D-index, Research.com 2026 ranking edition. Based on 17,934 ranked scientists.
D-Index Scientists This scientist
40–41 289 41
42–43 612
44–45 808
46–47 776
48–49 835
50–51 861
52–53 872
54–55 933
56–57 1,051
58–59 930
60–61 882
62–63 834
64–65 731
66–67 775
68–69 683
70–71 646
72–73 561
74–75 501
76–77 437
78–79 388
80–81 354
82–83 292
84–85 275
86–87 254
88–89 235
90–91 185
92–93 192
94–95 155
96–97 163
98–99 125
100–101 105
102–103 105
104–105 112
106–107 88
108–109 68
110–111 69
112–113 65
114–115 79
116–117 61
118–119 44
120–121 37
122–123 40
124–125 33
126–127 26
128–129 34
130–131 35
132–133 25
134–135 27
136–137 17
138–139 16
140–141 20
142–143 20
144–145 15
146–147 9
148–149 9
150–151 16
152–153 11
154–155 9
156–157 3
158 3
159+ 98
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Overview

Daniel F. Ortwine is a researcher affiliated with Genentech in the United States, specializing in the fields of Medicine, Biochemistry, Genetics and Molecular Biology, and Materials Science. Their work spans several subfields, including Materials Chemistry, Molecular Biology, Genetics, Oncology, and Pulmonary and Respiratory Medicine.

The research topics addressed by Ortwine cover a range of biomedical and chemical areas such as:

  • Ion channel regulation and function
  • Estrogen and related hormone effects
  • HER2/EGFR in Cancer Research
  • Crystallization and Solubility Studies
  • X-ray Diffraction in Crystallography
  • Advanced Breast Cancer Therapies
  • Cardiac electrophysiology and arrhythmias

Ortwine has published multiple scholarly articles on these topics. Some of their recent publications include:

  • "GDC-9545 (Giredestrant): A Potent and Orally Bioavailable Selective Estrogen Receptor Antagonist and Degrader with an Exceptional Preclinical Profile for ER+ Breast Cancer," 2021, Journal of Medicinal Chemistry
  • "Discovery of Acyl-sulfonamide Nav1.7 Inhibitors GDC-0276 and GDC-0310," 2021, Journal of Medicinal Chemistry
  • "Cryo-EM reveals an unprecedented binding site for NaV1.7 inhibitors enabling rational design of potent hybrid inhibitors," 2023, eLife
  • "Discovery of GNE-502 as an orally bioavailable and potent degrader for estrogen receptor positive breast cancer," 2021, Bioorganic & Medicinal Chemistry Letters
  • "BindingDB Entry 50008871: Discovery of a C-8 hydroxychromene as a potent degrader of estrogen receptor alpha with improved rat oral exposure over GDC-0927," 2021, PubMed

Their frequent coauthors include:

  • Jae H. Chang
  • Steven J. McKerrall
  • David H. Hackos
  • Antonio G. DiPasquale
  • Philippe Bergeron

Ortwine's work is published frequently in venues such as The Cambridge Structural Database, Journal of Medicinal Chemistry, Bioorganic & Medicinal Chemistry Letters, eLife, and ACS Medicinal Chemistry Letters, reflecting a focus on the intersection of chemistry and biomedical research.

Best Publications

  • Histone Deacetylase (HDAC) Inhibitor Kinetic Rate Constants Correlate with Cellular Histone Acetylation but Not Transcription and Cell Viability

    Benjamin E.L. Lauffer;Robert Mintzer;Rina Fong;Susmith Mukund

  • Structural basis of Nav1.7 inhibition by an isoform-selective small-molecule antagonist.

    Shivani Ahuja;Susmith Mukund;Lunbin Deng;Kuldip Khakh

  • Inhibitors of cholesterol biosynthesis. 3. Tetrahydro-4-hydroxy-6-[2-(1H-pyrrol-1-yl)ethyl]-2H-pyran-2-one inhibitors of HMG-CoA reductase. 2. Effects of introducing substituents at positions three and four of the pyrrole nucleus.

    B D Roth;C J Blankley;A W Chucholowski;E Ferguson

  • Discovery and Characterization of a Novel Inhibitor of Matrix Metalloprotease-13 That Reduces Cartilage Damage in Vivo without Joint Fibroplasia Side Effects

    Adam R. Johnson;Alexander G. Pavlovsky;Daniel F. Ortwine;Faith Prior

  • Discovery of GDC-0853: A Potent, Selective, and Noncovalent Bruton's Tyrosine Kinase Inhibitor in Early Clinical Development.

    James J. Crawford;Adam R. Johnson;Dinah L. Misner;Lisa D. Belmont

  • Substituted 2-Benzothiazolamines as Sodium Flux Inhibitors: Quantitative Structure-Activity Relationships and Anticonvulsant Activity

    Sheryl J. Hays;Michael J. Rice;Daniel F. Ortwine;Graham Johnson

  • X-ray structure of a hydroxamate inhibitor complex of stromelysin catalytic domain and its comparison with members of the zinc metalloproteinase superfamily.

    V. Dhanaraj;Q. Z. Ye;L. L. Johnson;D. J. Hupe

  • Battling Btk Mutants With Noncovalent Inhibitors That Overcome Cys481 and Thr474 Mutations

    Adam R. Johnson;Pawan Bir Kohli;Arna Katewa;Emily Gogol

  • 4-Phenylpyrrolo[3,4-c]carbazole-1,3(2H,6H)-dione inhibitors of the checkpoint kinase Wee1. Structure-activity relationships for chromophore modification and phenyl ring substitution.

    Brian D Palmer;Andrew M Thompson;R John Booth;Ellen M Dobrusin

  • Structure−Activity Relationships and Pharmacokinetic Analysis for a Series of Potent, Systemically Available Biphenylsulfonamide Matrix Metalloproteinase Inhibitors

    Patrick M. O'brien;Daniel F. Ortwine;Alexander G. Pavlovsky;Joseph A. Picard

  • N6-[2-(3,5-dimethoxyphenyl)-2-(2-methylphenyl)ethyl]adenosine and its uronamide derivatives. Novel adenosine agonists with both high affinity and high selectivity for the adenosine A2 receptor.

    Alexander J. Bridges;Robert F. Bruns;Daniel F. Ortwine;Steven R. Priebe

  • GDC-9545 (Giredestrant): A Potent and Orally Bioavailable Selective Estrogen Receptor Antagonist and Degrader with an Exceptional Preclinical Profile for ER+ Breast Cancer.

    Jun Liang;Jason R Zbieg;Robert A Blake;Jae H Chang

  • Styrylpyrazoles, styrylisoxazoles, and styrylisothiazoles. Novel 5-lipoxygenase and cyclooxygenase inhibitors.

    Daniel L. Flynn;Thomas R. Belliotti;Amal M. Boctor;David T. Connor

  • Novel Series of Achiral, Low Molecular Weight, and Potent HIV-1 Protease Inhibitors

    J. V. N. Vara Prasad;Kimberly S. Para;Elizabeth A. Lunney;Daniel F. Ortwine

  • Benzothiopyranoindazoles, a new class of chromophore modified anthracenedione anticancer agents. Synthesis and activity against murine leukemias.

    Showalter Hd;Angelo Mm;Berman Em;Kanter Gd

  • Synthesis and structure-activity relationships of pyrazolo[4,3-d]pyrimidin-7-ones as adenosine receptor antagonists

    Harriet W. Hamilton;Daniel F. Ortwine;Donald F. Worth;James A. Bristol

  • X-RAY STRUCTURE OF GELATINASE A CATALYTIC DOMAIN COMPLEXED WITH A HYDROXAMATE INHIBITOR

    Venugopal Dhanaraj;Mark G. Williams;Qi Zhuang Ye;Franck Molina

  • A rationalization of the acidic pH dependence for stromelysin-1 (Matrix metalloproteinase-3) catalysis and inhibition.

    Linda L. Johnson;Alexander G. Pavlovsky;Adam R. Johnson;Jeffrey A. Janowicz

  • Quinazolinones and Pyrido[3,4-d]pyrimidin-4-ones as Orally Active and Specific Matrix Metalloproteinase-13 Inhibitors for the Treatment of Osteoarthritis

    Jie Jack Li;Joe Nahra;Adam R. Johnson;Amy Bunker

  • X-ray structure of human stromelysin catalytic domain complexed with nonpeptide inhibitors: implications for inhibitor selectivity.

    Alexander G. Pavlovsky;Mark G. Williams;Qi Zhuang Ye;Daniel F. Ortwine

  • Inhibitors of cholesterol biosynthesis. 1. trans-6-(2-pyrrol-1-ylethyl)-4-hydroxypyran-2-ones, a novel series of HMG-CoA reductase inhibitors. 1. Effects of structural modifications at the 2- and 5-positions of the pyrrole nucleus.

    Bruce D. Roth;D. F. Ortwine;M. L. Hoefle;C. D. Stratton

Frequent Co-Authors

Frederick Cohen
Frederick Cohen Nurix Therapeutics
Tom L. Blundell
Tom L. Blundell University of Cambridge
William A. Denny
William A. Denny University of Auckland

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