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Robert B. Diasio

Robert B. Diasio

D-Index & Metrics

Medicine

D-Index
83
Citations
23065
World Ranking
15704
National Ranking
7904

Research.com Recognitions

  • 2008 - Fellow of the American Association for the Advancement of Science (AAAS)
  • Member of the Association of American Physicians
  • Member of the Association of American Physicians

Overview

Robert B. Diasio is affiliated with the Mayo Clinic in the United States and has contributed extensively to research in medicine, particularly in oncology and molecular biology. Their work includes a significant focus on colorectal cancer treatments and studies, as well as pancreatic and hepatic oncology research. Additional areas of interest include biochemical and molecular research, cancer genomics and diagnostics, genetic factors in colorectal cancer, cancer treatment and pharmacology, and genomics and chromatin dynamics.

Several frequent coauthors have collaborated with Diasio throughout their career: Steven M. Offer, Carlo R. Largiadèr, Remington E. Schmidt, Kelly J. Bouchonville, and Federico Innocenti.

The scientist has published multiple papers in frequent venues including JCO Precision Oncology, eLife, Cancer Research, Mayo Clinic Proceedings Innovations Quality & Outcomes, and Cancers.

  • Cancer Mortality Rates Increasing vs Cardiovascular Disease Mortality Decreasing in the World: Future Implications, 2021, Mayo Clinic Proceedings Innovations Quality & Outcomes
  • Testing for Dihydropyrimidine Dehydrogenase Deficiency to Individualize 5-Fluorouracil Therapy, 2022, Cancers
  • DPYD Testing: Time to Put Patient Safety First, 2023, Journal of Clinical Oncology
  • Haplotype structure defines effects of common DPYD variants c.85T > C (rs1801265) and c.496A > G (rs2297595) on dihydropyrimidine dehydrogenase activity: Implication for 5-fluorouracil toxicity, 2021, British Journal of Clinical Pharmacology
  • Pharmacogenomic-Guided Therapy in Colorectal Cancer, 2021, Clinical Pharmacology & Therapeutics

Throughout their career, Diasio has focused on understanding the genetic and pharmacogenomic factors influencing cancer treatment outcomes, with particular attention to dihydropyrimidine dehydrogenase (DPYD) testing and its impact on 5-fluorouracil therapy personalization.

They have been recognized by professional organizations and institutions, holding distinctions such as Fellow of the American Association for the Advancement of Science (AAAS) since 2008 and membership in the Association of American Physicians.

Best Publications

  • Clinical pharmacology of 5-fluorouracil.

    Robert B. Diasio;Barry E. Harris

  • Colorectal Tumors Responding to 5-Fluorouracil Have Low Gene Expression Levels of Dihydropyrimidine Dehydrogenase, Thymidylate Synthase, and Thymidine Phosphorylase

    Dennis Salonga;Kathleen D. Danenberg;Martin Johnson;Ralf Metzger

  • Clinical Pharmacokinetics of 5-Fluorouracil and Its Metabolites in Plasma, Urine, and Bile

    Glen D. Heggie;Jean-Pierre Sommadossi;David S. Cross;William J. Huster

  • Relationship between dihydropyrimidine dehydrogenase activity and plasma 5-fluorouracil levels with evidence for circadian variation of enzyme activity and plasma drug levels in cancer patients receiving 5-fluorouracil by protracted continuous infusion

    Barry E. Harris;Ruiling Song;Seng-jaw Soong;Robert B. Diasio

  • Familial deficiency of dihydropyrimidine dehydrogenase. Biochemical basis for familial pyrimidinemia and severe 5-fluorouracil-induced toxicity.

    R B Diasio;T L Beavers;J T Carpenter

  • Clinical Pharmacogenetics Implementation Consortium (CPIC) Guideline for Dihydropyrimidine Dehydrogenase Genotype and Fluoropyrimidine Dosing: 2017 Update

    Ursula Amstutz;Linda M. Henricks;Steven M. Offer;Julia Barbarino

  • Dihydropyrimidine Dehydrogenase Activity in Human Peripheral Blood Mononuclear Cells and Liver: Population Characteristics, Newly Identified Deficient Patients, and Clinical Implication in 5-Fluorouracil Chemotherapy

    Zhihong Lu;Ruiwen Zhang;Robert B. Diasio

  • Treatment of Cryptococcal Meningitis with Combination Amphotericin B and Flucytosine for Four as Compared with Six Weeks

    William E. Dismukes;Gretchen Cloud;Harry A. Gallis;Thomas M. Kerkering

  • A locus on 19p13 modifies risk of breast cancer in BRCA1 mutation carriers and is associated with hormone receptor-negative breast cancer in the general population

    Antonis C. Antoniou;Xianshu Wang;Zachary S. Fredericksen;Lesley McGuffog

  • Clinical Pharmacogenetics Implementation Consortium guidelines for dihydropyrimidine dehydrogenase genotype and fluoropyrimidine dosing.

    K E Caudle;C F Thorn;T E Klein;J J Swen

  • A common variant at the TERT-CLPTM1L locus is associated with estrogen receptor-negative breast cancer

    Christopher A. Haiman;Gary K. Chen;Celine M. Vachon;Federico Canzian

  • Method of down-regulating gene expression

    Sudhir Agrawal;Robert B. Diasio;Ruiwen Zhang

  • Histone deacetylase inhibitors: current status and overview of recent clinical trials.

    Xujun Ma;Hany H. Ezzeldin;Robert B. Diasio

  • The Continuum of Care: A Paradigm for the Management of Metastatic Colorectal Cancer

    Richard M. Goldberg;Mace L. Rothenberg;Eric Van Cutsem;Al B. Benson

  • Life-threatening toxicity in a dihydropyrimidine dehydrogenase-deficient patient after treatment with topical 5-fluorouracil

    Martin R. Johnson;Alexander Hageboutros;Kangsheng Wang;Lisa High

  • Severe 5-fluorouracil toxicity secondary to dihydropyrimidine dehydrogenase deficiency. A potentially more common pharmacogenetic syndrome.

    Barry E. Harris;John T. Carpenter;Robert B. Diasio

  • Toxicity of amphotericin B plus flucytosine in 194 patients with cryptococcal meningitis

    Alan M. Stamm;Alan M. Stamm;Robert B. Diasio;Robert B. Diasio;William E. Dismukes;William E. Dismukes;Smith Shadomy;Smith Shadomy

  • Severe neurotoxicity following 5-fluorouracil-based chemotherapy in a patient with dihydropyrimidine dehydrogenase deficiency.

    Chris H. Takimoto;Zhi Hong Lu;Ruiwen Zhang;Michael D. Liang

  • Dihydropyrimidine dehydrogenase deficiency, a pharmacogenetic syndrome associated with potentially life-threatening toxicity following 5-fluorouracil administration.

    Hany Ezzeldin;Robert Diasio

  • A meta-analysis of genome-wide association studies of breast cancer identifies two novel susceptibility loci at 6q14 and 20q11

    Afshan Siddiq;Fergus J. Couch;Gary K. Chen;Sara Lindström

Frequent Co-Authors

Stephen Barnes
Stephen Barnes University of Alabama at Birmingham
Sudhir Agrawal
Sudhir Agrawal University of Massachusetts Chan Medical School
Celine M. Vachon
Celine M. Vachon Mayo Clinic
Hiltrud Brauch
Hiltrud Brauch German Cancer Research Center
Peter A. Fasching
Peter A. Fasching University of Erlangen-Nuremberg
Esther M. John
Esther M. John Stanford University

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