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Biology and Biochemistry

D-Index
59
Citations
11034
World Ranking
12691
National Ranking
905

Overview

Ralf Ficner is affiliated with the University of Göttingen in Germany and has a research portfolio centered primarily in biochemistry, genetics, and molecular biology. Their scientific contributions encompass a broad range of topics related to RNA and protein synthesis mechanisms as well as enzyme structure and function.

The main fields of study for this scientist include:

  • Biochemistry, Genetics and Molecular Biology

Within these, the notable subfields covered are:

  • Molecular Biology
  • Materials Chemistry
  • Genetics
  • Pharmacology
  • Ecology

The key research topics they have explored consist of:

  • RNA and protein synthesis mechanisms
  • RNA Research and Splicing
  • RNA modifications and cancer
  • Enzyme Structure and Function
  • Bacterial Genetics and Biotechnology
  • Bacteriophages and microbial interactions
  • Microbial Natural Products and Biosynthesis

Ralf Ficner's publication record includes recent papers spanning from 2020 to 2021, appearing in a number of peer-reviewed journals. These papers include:

  • "Mapping protein interactions in the active TOM-TIM23 supercomplex" (2021) published in Nature Communications
  • "Regulation of DEAH-box RNA helicases by G-patch proteins" (2021) published in Biological Chemistry
  • "A meet-up of two second messengers: the c-di-AMP receptor DarB controls (p)ppGpp synthesis in Bacillus subtilis" (2021) published in Nature Communications
  • "A Cross-linking Mass Spectrometry Approach Defines Protein Interactions in Yeast Mitochondria" (2020) published in Molecular & Cellular Proteomics
  • "Structural analysis of the intrinsically disordered splicing factor Spp2 and its binding to the DEAH-box ATPase Prp2" (2020) published in Proceedings of the National Academy of Sciences

Frequent publication venues where this scientist has contributed include:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Acta Crystallographica Section F Structural Biology Communications
  • Biological Chemistry
  • Proceedings of the National Academy of Sciences
  • Acta Crystallographica Section D Structural Biology

Collaborative work is an important aspect of their research, with frequent coauthors listed as:

  • Piotr Neumann
  • Henning Urlaub
  • Achim Dickmanns
  • Jörg Stülke
  • Jana L. Heidemann

Best Publications

  • Structure of the E. coli ribosome–EF-Tu complex at <3 Å resolution by Cs-corrected cryo-EM.

    Niels Fischer;Piotr Neumann;Andrey L. Konevega;Lars V. Bock

  • Crystal Structure of the Spliceosomal 15.5Kd Protein Bound to a U4 Snrna Fragment

    Ivan Vidovic;Stephanie Nottrott;Stephanie Nottrott;Klaus Hartmuth;Klaus Hartmuth;Reinhard Lührmann;Reinhard Lührmann

  • Isolation, crystallization, crystal structure analysis and refinement of allophycocyanin from the cyanobacterium Spirulina platensis at 2.3 A resolution.

    Katjuša Brejc;Ralf Ficner;Robert Huber;Stefan Steinbacher

  • Crystal Structure of the Nuclear Export Receptor CRM1 in Complex with Snurportin1 and RanGTP

    Thomas Monecke;Thomas Güttler;Piotr Neumann;Achim Dickmanns

  • Crystal structure of the archaeal ammonium transporter Amt-1 from Archaeoglobus fulgidus

    Susana L. A. Andrade;Antje Dickmanns;Ralf Ficner;Oliver Einsle

  • Crystal structure of the polysialic acid-degrading endosialidase of bacteriophage K1F.

    Katharina Stummeyer;Achim Dickmanns;Martina Mühlenhoff;Rita Gerardy-Schahn

  • NES consensus redefined by structures of PKI-type and Rev-type nuclear export signals bound to CRM1

    Thomas Güttler;Tobias Madl;Piotr Neumann;Danilo Deichsel

  • Crystal structure of the surfactin synthetase‐activating enzyme Sfp: a prototype of the 4′‐phosphopantetheinyl transferase superfamily

    Klaus Reuter;Mohammad R. Mofid;Mohamed A. Marahiel;Ralf Ficner

  • Functional interaction of a novel 15.5kD [U4/U6.U5] tri-snRNP protein with the 5' stem-loop of U4 snRNA.

    Stephanie Nottrott;Klaus Hartmuth;Patrizia Fabrizio;Henning Urlaub

  • Crystal structure of a bacterial class 2 histone deacetylase homologue.

    Tine Kragh Nielsen;Christian Hildmann;Achim Dickmanns;Andreas Schwienhorst

  • Molecular basis for multiple sulfatase deficiency and mechanism for formylglycine generation of the human formylglycine-generating enzyme.

    Thomas Dierks;Achim Dickmanns;Andrea Preusser-Kunze;Bernhard Schmidt

  • Isolation, crystallization, crystal structure analysis and refinement of B-phycoerythrin from the red alga Porphyridium sordidum at 2.2 A resolution.

    Ralf Ficner;Karin Lobeck;Gabriele Schmidt;Robert Huber

  • Reconstitution of both steps of Saccharomyces cerevisiae splicing with purified spliceosomal components

    Zbigniew Warkocki;Peter Odenwälder;Jana Schmitzová;Florian Platzmann

  • The Aspergillus nidulans MAPK Module AnSte11-Ste50-Ste7-Fus3 Controls Development and Secondary Metabolism

    Özgür Bayram;Özlem Sarikaya Bayram;Yasar Luqman Ahmed;Jun-ichi Maruyama

  • The iron-sulphur protein RNase L inhibitor functions in translation termination.

    Sohail Khoshnevis;Thomas Gross;Carmen Rotte;Claudia Baierlein

  • Phosphorylation of human PRP28 by SRPK2 is required for integration of the U4/U6-U5 tri-snRNP into the spliceosome

    Rebecca Mathew;Klaus Hartmuth;Sina Möhlmann;Henning Urlaub

  • The Velvet Family of Fungal Regulators Contains a DNA-Binding Domain Structurally Similar to NF-κB

    Yasar Luqman Ahmed;Jennifer Gerke;Hee-Soo Park;Oezguer Bayram

  • The crystal structure of 3alpha -hydroxysteroid dehydrogenase/carbonyl reductase from Comamonas testosteroni shows a novel oligomerization pattern within the short chain dehydrogenase/reductase family.

    Clemens Grimm;Edmund Maser;Eric Möbus;Gerhard Klebe

  • A jack of all trades: the multiple roles of the unique essential second messenger cyclic di-AMP

    Fabian M. Commichau;Achim Dickmanns;Jan Gundlach;Ralf Ficner

  • Refined crystal structure of phycoerythrin from Porphyridium cruentum at 0.23-nm resolution and localization of the γ subunit

    Ralf Ficner;Robert Huber

Frequent Co-Authors

Henning Urlaub
Henning Urlaub University of Göttingen
Reinhard Lührmann
Reinhard Lührmann Max Planck Society
Rita Gerardy-Schahn
Rita Gerardy-Schahn Hannover Medical School
Gerhard Klebe
Gerhard Klebe Philipp University of Marburg
Kai Tittmann
Kai Tittmann University of Göttingen
Helmut Grubmüller
Helmut Grubmüller Max Planck Society
Holger Stark
Holger Stark Max Planck Society
Markus Zweckstetter
Markus Zweckstetter German Center for Neurodegenerative Diseases
Peter Rehling
Peter Rehling University of Göttingen
Jörg Stülke
Jörg Stülke University of Göttingen

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