World's Best Scientists 2026 revealed!

D-Index & Metrics

Biology and Biochemistry

D-Index
72
Citations
15090
World Ranking
6437
National Ranking
491

Research.com Recognitions

  • Fellow of The Academy of Medical Sciences, United Kingdom
  • Member of the European Molecular Biology Organization (EMBO)
  • Fellow of The Academy of Medical Sciences, United Kingdom
  • Member of the European Molecular Biology Organization (EMBO)
  • Fellow of The Academy of Medical Sciences, United Kingdom
  • Member of the European Molecular Biology Organization (EMBO)

Overview

Clare M. Isacke is affiliated with the Institute of Cancer Research in the United Kingdom. Their research primarily spans the fields of Medicine and Biochemistry, Genetics and Molecular Biology, with a strong focus on subfields including Oncology, Cancer Research, Pulmonary and Respiratory Medicine, Molecular Biology, and Immunology.

The scientist's work investigates key topics related to cancer biology and treatment. These topics include:

  • Cancer Cells and Metastasis
  • Cancer Genomics and Diagnostics
  • Breast Cancer Treatment Studies
  • HER2/EGFR in Cancer Research
  • CAR-T cell therapy research
  • Advanced Breast Cancer Therapies
  • Cancer Immunotherapy and Biomarkers

The recent published papers of Clare M. Isacke demonstrate an active role in advancing cancer research. Notable recent publications include:

  • "Cancer-Associated Fibroblasts Suppress CD8+ T-cell Infiltration and Confer Resistance to Immune-Checkpoint Blockade" (2022, Cancer Research)
  • "Metabolic Fingerprinting Links Oncogenic PIK3CA with Enhanced Arachidonic Acid-Derived Eicosanoids" (2020, Cell)
  • "Assessing CSF ctDNA to Improve Diagnostic Accuracy and Therapeutic Monitoring in Breast Cancer Leptomeningeal Metastasis" (2021, Clinical Cancer Research)
  • "Age-associated microenvironmental changes highlight the role of PDGF-C in ER+ breast cancer metastatic relapse" (2023, Nature Cancer)
  • "International multidisciplinary consensus on the integration of radiotherapy with new systemic treatments for breast cancer: European Society for Radiotherapy and Oncology (ESTRO)-endorsed recommendations" (2024, The Lancet Oncology)

Clare M. Isacke frequently collaborates with several researchers, which include:

  • Marjan Iravani
  • Syed Haider
  • Amanda Fitzpatrick
  • Andrew Tutt
  • Liam Jenkins

The scientist's work has been published in several prominent venues related to cancer research and clinical studies. Frequent publication venues include:

  • Cancer Research
  • bioRxiv (Cold Spring Harbor Laboratory)
  • Nature Communications
  • Journal of Clinical Investigation
  • Radiotherapy and Oncology

Recognition within the scientific community includes appointments as a Member of the European Molecular Biology Organization (EMBO) and a Fellow of The Academy of Medical Sciences, United Kingdom.

Best Publications

  • The mannose receptor family.

    Lucy East;Clare M Isacke

  • The NF2 tumor suppressor gene product, merlin, mediates contact inhibition of growth through interactions with CD44

    Helen Morrison;Larry S. Sherman;James Legg;Fatima Banine

  • Structural alteration of viral homologue of receptor proto-oncogene fms at carboxyl terminus

    Lisa Coussens;Charles Van Beveren;Douglas Smith;Ellson Chen

  • CD24 staining of mouse mammary gland cells defines luminal epithelial, myoepithelial/basal and non-epithelial cells

    Katherine E. Sleeman;Howard Kendrick;Alan Ashworth;Clare M. Isacke

  • Dissociation of estrogen receptor expression and in vivo stem cell activity in the mammary gland.

    Katherine E. Sleeman;Howard Kendrick;David Robertson;Clare M. Isacke

  • The role of the CD44 transmembrane and cytoplasmic domains in co-ordinating adhesive and signalling events

    Rick F. Thorne;James W. Legg;Clare M. Isacke

  • A novel PKC-regulated mechanism controls CD44 ezrin association and directional cell motility.

    James W. Legg;Charlotte A. Lewis;Maddy Parsons;Tony Ng

  • The hyaluronan receptor, CD44.

    Clare M. Isacke;Helen Yarwood

  • A HaemAtlas: Characterizing gene expression in differentiated human blood cells

    Nicholas A. Watkins;Arief Gusnanto;Bernard de Bono;Subhajyoti De

  • A Role for Fibrillar Collagen Deposition and the Collagen Internalization Receptor Endo180 in Glioma Invasion

    Ivo J Huijbers;Marjan Iravani;Sergey Popov;David M Robertson

  • Multiple immunofluorescence labelling of formalin-fixed paraffin-embedded (FFPE) tissue

    David Robertson;Kay Savage;Jorge S Reis-Filho;Clare M Isacke

  • Identification and functional analysis of the ezrin-binding site in the hyaluronan receptor, CD44

    James W. Legg;Clare M. Isacke

  • Endosialin (TEM1, CD248) is a marker of stromal fibroblasts and is not selectively expressed on tumour endothelium.

    John R. MacFadyen;Oliver Haworth;David Roberston;Deborah Hardie

  • The protein-tyrosine kinase substrate p36 is also a substrate for protein kinase C in vitro and in vivo.

    K L Gould;J R Woodgett;C M Isacke;T Hunter

  • Endo180, an endocytic recycling glycoprotein related to the macrophage mannose receptor is expressed on fibroblasts, endothelial cells and macrophages and functions as a lectin receptor

    Humma Sheikh;Helen Yarwood;Alan Ashworth;Clare M. Isacke

  • Restricted expression of the hyaluronan receptor, CD44, during postimplantation mouse embryogenesis suggests key roles in tissue formation and patterning

    Susan C. Wheatley;Clare M. Isacke;Philip H. Crossley

  • CD molecules 2005: human cell differentiation molecules

    Heddy Zola;Bernadette Swart;Ian Nicholson;Bent Aasted

  • Identification and Characterization of the Endocytic Transmembrane Glycoprotein Endo180 as a Novel Collagen Receptor

    Dirk Wienke;John R. MacFadyen;Clare M. Isacke

  • A role for glial cell derived neurotrophic factor induced expression by inflammatory cytokines and RET/GFR alpha 1 receptor up-regulation in breast cancer.

    Esseghir S;Todd Sk;Hunt T;Poulsom R

  • Epithelial and Mesenchymal Subpopulations Within Normal Basal Breast Cell Lines Exhibit Distinct Stem Cell/Progenitor Properties

    David Sarrio;Chris K. Franklin;Alan Mackay;Jorge S. Reis‐Filho

Frequent Co-Authors

Christopher D. Buckley
Christopher D. Buckley University of Oxford
Jorge S. Reis-Filho
Jorge S. Reis-Filho Memorial Sloan Kettering Cancer Center
Alan Ashworth
Alan Ashworth University of California, San Francisco
David Robertson
David Robertson Vanderbilt University
Marketa Zvelebil
Marketa Zvelebil University of Basel
Tony Hunter
Tony Hunter Salk Institute for Biological Studies
Christopher J. Lord
Christopher J. Lord Institute of Cancer Research
Mitch Dowsett
Mitch Dowsett Breast Cancer Research Foundation
David L. Huso
David L. Huso Johns Hopkins University
Robert M.W. Hofstra
Robert M.W. Hofstra Erasmus University Rotterdam

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