World's Best Scientists 2026 revealed!

D-Index & Metrics

Chemistry

D-Index
40
Citations
5515
World Ranking
17912
National Ranking
1297

Overview

Kai Tittmann is affiliated with the University of Göttingen in Germany. Their research primarily focuses on the field of Biochemistry, Genetics and Molecular Biology, with notable work in the subfields of Molecular Biology, Biochemistry, Neurology, Clinical Biochemistry, and Inorganic Chemistry.

The scientist's work covers a range of biochemical and molecular topics including:

  • Biochemical Acid Research Studies
  • Redox biology and oxidative stress
  • Metabolism and Genetic Disorders
  • Sulfur Compounds in Biology
  • Metal-Catalyzed Oxygenation Mechanisms
  • Alcoholism and Thiamine Deficiency
  • Enzyme Structure and Function

Kai Tittmann has contributed to several publications with diverse research subjects. Some recent papers authored or coauthored by them include:

  • "Protein-metabolite interactomics of carbohydrate metabolism reveal regulation of lactate dehydrogenase" (2023, Science)
  • "A lysine-cysteine redox switch with an NOS bridge regulates enzyme function" (2021, Nature)
  • "Widespread occurrence of covalent lysine-cysteine redox switches in proteins" (2022, Nature Chemical Biology)
  • "Discovery of a Regulatory Subunit of the Yeast Fatty Acid Synthase" (2020, Cell)
  • "N-hydroxypipecolic acid-induced transcription requires the salicylic acid signaling pathway at basal SA levels" (2021, PLANT PHYSIOLOGY)

Their frequent coauthors include:

  • Fabian Rabe von Pappenheim
  • Jon Uranga
  • Ricardo A. Mata
  • Lisa-Marie Funk
  • Marie Wensien

Publications by Kai Tittmann appear regularly in leading scientific venues such as:

  • Nature Chemical Biology
  • Nature Communications
  • bioRxiv (Cold Spring Harbor Laboratory)
  • Biochemistry
  • ACS Catalysis

Best Publications

  • How Thiamine Diphosphate Is Activated in Enzymes

    Dorothee Kern;Gunther Kern;Holger Neef;Kai Tittmann

  • Thiamin diphosphate catalysis: enzymic and nonenzymic covalent intermediates.

    Ronald Kluger;Kai Tittmann

  • The inhibition mechanism of human 20S proteasomes enables next-generation inhibitor design

    Jil Schrader;Fabian Henneberg;Ricardo A. Mata;Kai Tittmann

  • NMR analysis of covalent intermediates in thiamin diphosphate enzymes.

    Kai Tittmann;Ralph Golbik;Kathrin Uhlemann;Ludmila Khailova

  • Protein-metabolite interactomics of carbohydrate metabolism reveal regulation of lactate dehydrogenase

    Unknown

  • The crystal structure of human transketolase and new insights into its mode of action.

    Lars Mitschke;Christoph Parthier;Kathrin Schröder-Tittmann;Johannes Coy

  • The catalytic cycle of a thiamin diphosphate enzyme examined by cryocrystallography.

    Georg Wille;Danilo Meyer;Andrea Steinmetz;Erik Hinze

  • Strain and Near Attack Conformers in Enzymic Thiamin Catalysis: X-ray Crystallographic Snapshots of Bacterial Transketolase in Covalent Complex with Donor Ketoses Xylulose 5-phosphate and Fructose 6-phosphate, and in Noncovalent Complex with Acceptor Aldose Ribose 5-phosphate.

    Peter Asztalos;Christoph Parthier;Ralph Golbik;Martin Kleinschmidt

  • Mechanisms of acetohydroxyacid synthases

    David M Chipman;Ronald G Duggleby;Kai Tittmann

  • Studies on structure-function relationships of indolepyruvate decarboxylase from Enterobacter cloacae, a key enzyme of the indole acetic acid pathway.

    Anja Schütz;Ralph Golbik;Kai Tittmann;Dmitri I. Svergun

  • ProteoPlex: stability optimization of macromolecular complexes by sparse-matrix screening of chemical space

    Ashwin Chari;David Haselbach;Jan-Martin Kirves;Juergen Ohmer

  • A lysine-cysteine redox switch with an NOS bridge regulates enzyme function.

    Marie Wensien;Marie Wensien;Fabian Rabe von Pappenheim;Fabian Rabe von Pappenheim;Lisa-Marie Funk;Lisa-Marie Funk;Patrick Kloskowski;Patrick Kloskowski

  • Identification, characterization, and structure analysis of the cyclic di-AMP-binding PII-like signal transduction protein DarA.

    Jan Gundlach;Achim Dickmanns;Kathrin Schröder-Tittmann;Piotr Neumann

  • Low-barrier hydrogen bonds in enzyme cooperativity

    Shaobo Dai;Shaobo Dai;Lisa-Marie Funk;Lisa-Marie Funk;Fabian Rabe von Pappenheim;Fabian Rabe von Pappenheim;Viktor Sautner;Viktor Sautner

  • PtdInsP2 and PtdSer cooperate to trap synaptotagmin-1 to the plasma membrane in the presence of calcium

    Ángel Pérez-Lara;Anusa Thapa;Sarah B Nyenhuis;David A Nyenhuis

  • Sub-ångström-resolution crystallography reveals physical distortions that enhance reactivity of a covalent enzymatic intermediate

    Stefan Lüdtke;Piotr Neumann;Karl M. Erixon;Finian Leeper

  • Conversion of pyruvate decarboxylase into an enantioselective carboligase with biosynthetic potential.

    Danilo Meyer;Lydia Walter;Geraldine Kolter;Martina Pohl

  • Phosphorylation of serine 264 impedes active site accessibility in the E1 component of the human pyruvate dehydrogenase multienzyme complex.

    Franziska Seifert;Ewa Ciszak;Lioubov Korotchkina;Ralph Golbik

  • Radical phosphate transfer mechanism for the thiamin diphosphate- and FAD-dependent pyruvate oxidase from Lactobacillus plantarum. Kinetic coupling of intercofactor electron transfer with phosphate transfer to acetyl-thiamin diphosphate via a transient FAD semiquinone/hydroxyethyl-ThDP radical pair.

    Kai Tittmann;Georg Wille;Ralph Golbik;Annett Weidner

  • Glyoxylate carboligase lacks the canonical active site glutamate of thiamine-dependent enzymes

    Alexander Kaplun;Elad Binshtein;Maria Vyazmensky;Andrea Steinmetz

  • Control of the diadenylate cyclase CdaS in Bacillus subtilis: an autoinhibitory domain limits cyclic di-AMP production.

    Felix M.P. Mehne;Kathrin Schröder-Tittmann;Robyn T. Eijlander;Christina Herzberg

  • Binding and activation of thiamin diphosphate in acetohydroxyacid synthase.

    Ahuva Bar-Ilan;Vitaly Balan;Kai Tittmann;Ralph Golbik

Frequent Co-Authors

Holger Stark
Holger Stark Max Planck Society
Ralf Ficner
Ralf Ficner University of Göttingen
Frank Jordan
Frank Jordan Rutgers, The State University of New Jersey
Henning Urlaub
Henning Urlaub University of Göttingen
William Furey
William Furey University of Pittsburgh
Mulchand S. Patel
Mulchand S. Patel University at Buffalo, State University of New York
Gunter Schneider
Gunter Schneider Karolinska Institute
Reinhard Jahn
Reinhard Jahn Max Planck Society
Ronald G. Duggleby
Ronald G. Duggleby University of Queensland
David S. Cafiso
David S. Cafiso University of Virginia

If you think any of the details on this page are incorrect, let us know.

Report an issue

We appreciate your kind effort to assist us to improve this page, it would be helpful providing us with as much detail as possible in the text box below:

Related Online Degrees & Career Pathways

Studying Chemistry in the USA opens the door to diverse career opportunities across science and healthcare fields. Many students interested in applied chemistry explore roles like pharmacy, where understanding drug composition and interactions is vital. To pursue this, it’s essential to meet specific pharmacist education requirements, which often involve advanced degrees and licensure.

For those drawn to forensic applications, a background in chemistry is invaluable. Positions such as forensic autopsy technicians require specialized knowledge to assist in crime investigations. Exploring the career pathway of a forensic autopsy technician can provide practical insights into the roles and responsibilities involved.

Many students now opt for flexible learning options, including forensic science degree online programs. These affordable offerings allow learners to gain expertise while balancing other commitments.

Additionally, pursuing graduate-level education in behavioral aspects of crime is possible through forensic psychology graduate programs online. This pathway complements a chemistry foundation with psychological analysis skills, broadening career options.

Best Scientists Citing Kai Tittmann

Trending Scientists