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Biology and Biochemistry

D-Index
73
Citations
35201
World Ranking
5794
National Ranking
2738

Overview

Peter S. Klein is affiliated with the University of Pennsylvania in the United States. Their research primarily spans the fields of biochemistry, genetics, and molecular biology, with 27 publications reflecting deep engagement in these areas. Medicine is also a significant part of their work, comprising nine publications.

The scientist's subfields of study include molecular biology, genetics, cell biology, hematology, and immunology. These areas highlight a broad focus on cellular processes and genetic regulation, especially in relation to diseases and developmental biology.

Research topics covered extensively by Peter S. Klein include:

  • Wnt/β-catenin signaling in development and cancer
  • Genetics and neurodevelopmental disorders
  • Cancer-related gene regulation
  • Acute myeloid leukemia research
  • SARS-CoV-2 and COVID-19 research
  • Trace elements in health
  • Hippo pathway signaling and YAP/TAZ

Frequent publication venues for their work include:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Cells
  • Blood
  • Proceedings of the National Academy of Sciences
  • Developmental Biology

Recent publications demonstrate a focus on cellular signaling pathways and viral protein targeting, with notable papers such as:

  • Lithium and Therapeutic Targeting of GSK-3 (2021) in Cells
  • Targeting the coronavirus nucleocapsid protein through GSK-3 inhibition (2021) in Proceedings of the National Academy of Sciences
  • Chromatin accessibility and histone acetylation in the regulation of competence in early development (2020) in Developmental Biology
  • Targeting the Coronavirus Nucleocapsid Protein through GSK-3 Inhibition (2021) in bioRxiv (Cold Spring Harbor Laboratory)
  • When You Come to a Fork in the Road, Take It: Wnt Signaling Activates Multiple Pathways through the APC/Axin/GSK-3 Complex (2023) in Cells

Collaborative work features several frequent co-authors, illustrating interdisciplinary cooperation. These co-authors include Xiaolei Liu, Rebecca L. Myers, Chenchen Li, Sudhish A. Devadiga, and Mathieu Quesnel-Vallières.

Best Publications

  • Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)

    Daniel J. Klionsky;Amal Kamal Abdel-Aziz;Sara Abdelfatah;Mahmoud Abdellatif

  • A molecular mechanism for the effect of lithium on development

    Peter S. Klein;Douglas A. Melton

  • Histone deacetylase is a direct target of valproic acid, a potent anticonvulsant, mood stabilizer, and teratogen

    Christopher J. Phiel;Fang Zhang;Eric Y. Huang;Matthew G. Guenther

  • GSK-3α regulates production of Alzheimer's disease amyloid-β peptides

    Christopher J. Phiel;Christina A. Wilson;Virginia M.-Y. Lee;Peter S. Klein

  • Activation of the Wnt Signaling Pathway: A Molecular Mechanism for Lithium Action

    Chester M. Hedgepeth;Leslee J. Conrad;Jie Zhang;Hui-Chuan Huang

  • Nuclear receptor rev-erbα is a critical lithium-sensitive component of the circadian clock

    Lei Yin;Jing Wang;Peter S. Klein;Mitchell A. Lazar

  • Molecular targets of lithium action.

    Christopher J Phiel;Peter S Klein

  • Lithium Reduces Tau Phosphorylation by Inhibition of Glycogen Synthase Kinase-3

    Ming Hong;Daniel C.R. Chen;Peter S. Klein;Virginia M.-Y. Lee

  • Phase III Randomized Study of Bendamustine Compared With Chlorambucil in Previously Untreated Patients With Chronic Lymphocytic Leukemia

    Wolfgang U. Knauf;Toshko Lissichkov;Ali Aldaoud;Anna Liberati

  • Histone Deacetylase Is a Target of Valproic Acid-Mediated Cellular Differentiation

    Nadia Gurvich;Oxana M. Tsygankova;Judy L. Meinkoth;Peter S. Klein

  • Inhibitory phosphorylation of glycogen synthase kinase-3 (GSK-3) in response to lithium. Evidence for autoregulation of GSK-3.

    Fang Zhang;Christopher J. Phiel;Laura Spece;Nadia Gurvich

  • A chemoattractant receptor controls development in Dictyostelium discoideum.

    Peter S. Klein;Tzeli J. Sun;Charles L. Saxe;Alan R. Kimmel

  • O2 regulates stem cells through Wnt/β-catenin signalling

    Jolly Mazumdar;W. Timothy O'Brien;Randall S. Johnson;Joseph C. LaManna

  • GSK-3 and Wnt Signaling in Neurogenesis and Bipolar Disorder.

    Alexander J. Valvezan;Peter S. Klein

  • Glycogen synthase kinase-3beta haploinsufficiency mimics the behavioral and molecular effects of lithium.

    W Timothy O'Brien;Amber DeAra Harper;Fernando Jové;James R Woodgett

  • Hypomorphic mutations in PRF1, MUNC13-4, and STXBP2 are associated with adult-onset familial HLH

    Kejian Zhang;Michael B. Jordan;Rebecca A. Marsh;Judith A. Johnson

  • A unique geochemical record at the Permian/Triassic boundary

    William T. Holser;Hans-Peter Schönlaub;Moses Attrep;Klaus Boeckelmann

  • The Frizzled family: receptors for multiple signal transduction pathways.

    Hui-Chuan Huang;Peter S Klein

  • Dishevelled phosphorylation, subcellular localization and multimerization regulate its role in early embryogenesis

    Ute Rothbächer;Micheline N. Laurent;Matthew A. Deardorff;Peter S. Klein

  • Cellular Plasticity Cascades in the Pathophysiology and Treatment of Bipolar Disorder

    Robert J Schloesser;Jian Huang;Peter S Klein;Husseini K Manji

Frequent Co-Authors

Peter N. Devreotes
Peter N. Devreotes Johns Hopkins University
Jian Huang
Jian Huang University of Iowa
Jack W. Singer
Jack W. Singer University of Washington
Matthew A. Deardorff
Matthew A. Deardorff Children's Hospital of Philadelphia
Winfried Rief
Winfried Rief Philipp University of Marburg
Maria Blettner
Maria Blettner Johannes Gutenberg University of Mainz
John W. Tobias
John W. Tobias University of Pennsylvania
Nadia Harbeck
Nadia Harbeck Ludwig-Maximilians-Universität München
Virginia M.-Y. Lee
Virginia M.-Y. Lee University of Pennsylvania
Mohammad A. Kamal
Mohammad A. Kamal Princess Nourah bint Abdulrahman University

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