World's Best Scientists 2026 revealed!

D-Index & Metrics

Medicine

D-Index
95
Citations
26235
World Ranking
10211
National Ranking
5250

Overview

De-Maw Chuang is affiliated with the National Institutes of Health in the United States. Their research spans multiple fields, primarily within biochemistry, genetics, and molecular biology, along with medicine. Specific subfields include molecular biology, neurology, clinical psychology, epidemiology, and complementary and alternative medicine.

Their scholarly work engages deeply with topics such as fibroblast growth factor research, Kruppel-like factors research, epigenetics and DNA methylation, intracerebral and subarachnoid hemorrhage research, and traumatic brain injury as well as neurovascular disturbances. Acupuncture treatment research also forms part of their research focus.

  • Fibroblast Growth Factor Research
  • Kruppel-like factors research
  • Epigenetics and DNA Methylation
  • Intracerebral and Subarachnoid Hemorrhage Research
  • Traumatic Brain Injury and Neurovascular Disturbances
  • Traumatic Brain Injury Research
  • Acupuncture Treatment Research Studies

De-Maw Chuang has authored several recent papers covering experimental stroke, neurodegenerative disease models, oxidative stress, inflammation, and brain injury mechanisms. Notable publications include:

  • "Mesenchymal Stem Cells Overexpressing FGF21 Preserve Blood-Brain Barrier Integrity in Experimental Ischemic Stroke," 2023, published in Translational Stroke Research
  • "Overexpression of fibroblast growth factor-21 (FGF-21) protects mesenchymal stem cells against caspase-dependent apoptosis induced by oxidative stress and inflammation," 2020, published in Cell Biology International
  • "Electroacupuncture improves TBI dysfunction by targeting HDAC overexpression and BDNF-associated Akt/GSK-3β signaling," 2022, published in Frontiers in Cellular Neuroscience
  • "Intranasal Delivery of Lithium Salt Suppresses Inflammatory Pyroptosis in the Brain and Ameliorates Memory Loss and Depression-like Behavior in 5XFAD Mice," 2025, published in Journal of Neuroimmune Pharmacology
  • "Intranasal administration of mesenchymal stem cells overexpressing FGF21 demonstrates therapeutic potential in experimental Parkinson's disease," 2024, published in Neurotherapeutics

The research venues where De-Maw Chuang's work appears include Translational Stroke Research, Frontiers in Cellular Neuroscience, Cell Biology International, Journal of Neuroimmune Pharmacology, and Neurotherapeutics.

  • Translational Stroke Research
  • Frontiers in Cellular Neuroscience
  • Cell Biology International
  • Journal of Neuroimmune Pharmacology
  • Neurotherapeutics

Collaboration is also a significant aspect of De-Maw Chuang's research activities. Frequent co-authors include Shih-Ya Hung, Piplu Bhuiyan, Liang Ge, Ying Wang, and Huafeng Wei, each having worked together on multiple occasions.

Best Publications

  • Multiple roles of HDAC inhibition in neurodegenerative conditions.

    De-Maw Chuang;Yan Leng;Zoya Marinova;Hyeon-Ju Kim

  • Lithium activates the serine/threonine kinase Akt-1 and suppresses glutamate-induced inhibition of Akt-1 activity in neurons

    Elzbieta Chalecka-Franaszek;De-Maw Chuang

  • Histone deacetylase inhibitors exhibit anti-inflammatory and neuroprotective effects in a rat permanent ischemic model of stroke: multiple mechanisms of action.

    Hyeon Ju Kim;Michael Rowe;Ming Ren;Jau-Shyong Hong

  • Long Term Lithium Treatment Suppresses p53 and Bax Expression but Increases Bcl-2 Expression A PROMINENT ROLE IN NEUROPROTECTION AGAINST EXCITOTOXICITY

    Ren-Wu Chen;De-Maw Chuang

  • Chronic lithium treatment robustly protects neurons in the central nervous system against excitotoxicity by inhibiting N-methyl-d-aspartate receptor-mediated calcium influx

    Shigeyuki Nonaka;Christopher J. Hough;De-Maw Chuang

  • Coupling of inositol phospholipid metabolism with excitatory amino acid recognition sites in rat hippocampus.

    F. Nicoletti;J. L. Meek;M. J. Iadarola;D. M. Chuang

  • Therapeutic Potential of Mood Stabilizers Lithium and Valproic Acid: Beyond Bipolar Disorder

    Chi-Tso Chiu;Zhifei Wang;Joshua G. Hunsberger;De-Maw Chuang

  • Valproic acid reduces brain damage induced by transient focal cerebral ischemia in rats: potential roles of histone deacetylase inhibition and heat shock protein induction

    Ming Ren;Yan Leng;MiRa Jeong;Peter R. Leeds

  • Valproate protects dopaminergic neurons in midbrain neuron/glia cultures by stimulating the release of neurotrophic factors from astrocytes

    Po-See Chen;G. S. Peng;G. S. Peng;G. Li;S. Yang

  • The mood stabilizers lithium and valproate selectively activate the promoter IV of brain-derived neurotrophic factor in neurons

    Yasuda S;Liang Mh;Marinova Z;Yahyavi A

  • Lithium protection against glutamate excitotoxicity in rat cerebral cortical neurons: involvement of NMDA receptor inhibition possibly by decreasing NR2B tyrosine phosphorylation

    Ryota Hashimoto;Christopher Hough;Takanobu Nakazawa;Tadashi Yamamoto

  • GLYCERALDEHYDE-3-PHOSPHATE DEHYDROGENASE, APOPTOSIS, AND NEURODEGENERATIVE DISEASES*

    De-Maw Chuang;Christopher Hough;Vladimir V. Senatorov

  • Histone deacetylase inhibitors up-regulate astrocyte GDNF and BDNF gene transcription and protect dopaminergic neurons

    Xuefei Wu;Po See Chen;Po See Chen;Shannon Dallas;Belinda Wilson

  • Lithium induces brain-derived neurotrophic factor and activates TrkB in rodent cortical neurons: an essential step for neuroprotection against glutamate excitotoxicity.

    Ryota Hashimoto;Nobuyuki Takei;Kazuhiro Shimazu;Lori Christ

  • The HDAC inhibitor, sodium butyrate, stimulates neurogenesis in the ischemic brain

    Hyeon Ju Kim;Peter Leeds;De-Maw Chuang

  • Neuroprotective effects of chronic lithium on focal cerebral ischemia in rats.

    Shigeyuki Nonaka;De-Maw Chuang

  • Synergistic neuroprotective effects of lithium and valproic acid or other histone deacetylase inhibitors in neurons: roles of glycogen synthase kinase-3 inhibition.

    Yan Leng;Min-Huei Liang;Ming Ren;Zoya Marinova

  • Neuroprotective effects of lithium in cultured cells and animal models of diseases.

    De-Maw Chuang;Ren-Wu Chen;Elzbieta Chalecka-Franaszek;Elzbieta Chalecka-Franaszek;Ming Ren

  • COMBINED LITHIUM AND VALPROATE TREATMENT DELAYS DISEASE ONSET, REDUCES NEUROLOGICAL DEFICITS AND PROLONGS SURVIVAL IN AN AMYOTROPHIC LATERAL SCLEROSIS MOUSE MODEL

    H.-L. Feng;Y. Leng;C.-H. Ma;J. Zhang

  • Evidence that glyceraldehyde-3-phosphate dehydrogenase is involved in age-induced apoptosis in mature cerebellar neurons in culture

    Ryoichi Ishitani;Katsuyoshi Sunaga;Atsushi Hirano;Paul Saunders

Frequent Co-Authors

Erminio Costa
Erminio Costa National Institutes of Health
Wan-Wan Lin
Wan-Wan Lin National Taiwan University
Po See Chen
Po See Chen National Cheng Kung University
Robert M. Post
Robert M. Post George Washington University
Ryota Hashimoto
Ryota Hashimoto National Center of Neurology and Psychiatry
Bryan L. Roth
Bryan L. Roth University of North Carolina at Chapel Hill
Jau-Shyong Hong
Jau-Shyong Hong National Institutes of Health
Thomas N. Chase
Thomas N. Chase National Institutes of Health
Susan R. Weiss
Susan R. Weiss University of Pennsylvania
Richard Jed Wyatt
Richard Jed Wyatt National Institutes of Health

If you think any of the details on this page are incorrect, let us know.

Report an issue

We appreciate your kind effort to assist us to improve this page, it would be helpful providing us with as much detail as possible in the text box below:

Related Online Degrees & Career Pathways

Exploring related online programs can be an excellent way to enter or advance in the medical field. Many students consider online rn to bsn programs without clinical requirements, which provide greater flexibility and faster completion for working registered nurses who want to earn a bachelor's degree.

For those aiming for advanced practice and leadership roles, a Doctor of Nursing Practice (DNP) is a popular choice. You can find dnp programs online that allow you to earn this terminal degree on your schedule. There are also easiest online dnp programs that prioritize accessibility and work-life balance, ideal for busy professionals.

If you’re seeking a quicker entry into nursing, fast track lpn programs online can help you start your healthcare career sooner. Each of these pathways offers unique benefits, allowing you to choose the program that fits your career goals and current commitments.

Best Scientists Citing De-Maw Chuang

Trending Scientists

Recently Published Articles