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Biology and Biochemistry

D-Index
49
Citations
12890
World Ranking
17875
National Ranking
7315

Overview

Eckhard Jankowsky is a researcher affiliated with Case Western Reserve University in the United States. Their work primarily spans the field of Biochemistry, Genetics and Molecular Biology, with a focused expertise in Molecular Biology. Additional areas of research include Oncology, Cancer Research, Pulmonary and Respiratory Medicine, and Epidemiology.

The scientist's research topics concentrate extensively on RNA-related studies. Key areas include RNA Research and Splicing, RNA modifications and cancer, RNA and protein synthesis mechanisms, Inflammatory Biomarkers in Disease Prognosis, DNA and Nucleic Acid Chemistry, RNA regulation and disease, and Prostate Cancer Treatment and Research.

Their recent papers demonstrate engagement with molecular and cellular mechanisms through the following publications:

  • Small molecules as potent biphasic modulators of protein liquid-liquid phase separation, 2020, Nature Communications
  • Cellular functions of eukaryotic RNA helicases and their links to human diseases, 2023, Nature Reviews Molecular Cell Biology
  • The kinetic landscape of an RNA-binding protein in cells, 2021, Nature
  • Piwil1 Regulates Glioma Stem Cell Maintenance and Glioblastoma Progression, 2021, Cell Reports
  • A comparative study of small molecules targeting eIF4A, 2020, RNA

Frequent co-authors in their research collaborations include:

  • Xuan Ye
  • Sarah Venus
  • Andrea Putnam
  • Donny D. Licatalosi
  • Zhaofeng Gao

The venues where Eckhard Jankowsky has frequently published include:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Nature Communications
  • Neuro-Oncology
  • Journal of Molecular Biology
  • Nature

Best Publications

  • From unwinding to clamping — the DEAD box RNA helicase family

    Patrick Linder;Eckhard Jankowsky

  • SF1 and SF2 helicases: family matters.

    Margaret E. Fairman-Williams;Ulf Peter Guenther;Eckhard Jankowsky

  • mda-5: An interferon-inducible putative RNA helicase with double-stranded RNA-dependent ATPase activity and melanoma growth-suppressive properties

    Dong Chul Kang;Rahul V. Gopalkrishnan;Rahul V. Gopalkrishnan;Qingping Wu;Qingping Wu;Eckhard Jankowsky

  • RNA helicases at work: binding and rearranging

    Eckhard Jankowsky

  • Inherited and Somatic Defects in DDX41 in Myeloid Neoplasms.

    Chantana Polprasert;Isabell Schulze;Mikkael Sekeres;Hideki Makishima

  • Active Disruption of an RNA-Protein Interaction by a DExH/D RNA Helicase

    Eckhard Jankowsky;Christian H. Gross;Stewart Shuman;Anna Marie Pyle;Anna Marie Pyle

  • Protein displacement by DExH/D "RNA helicases" without duplex unwinding.

    Margaret E. Fairman;Patricia A. Maroney;Wen Wang;Heath A. Bowers

  • RNA helicases--one fold for many functions.

    Eckhard Jankowsky;Margaret E Fairman

  • The hepatitis C viral NS3 protein is a processive DNA helicase with cofactor enhanced RNA unwinding.

    Phillip S. Pang;Eckhard Jankowsky;Paul J. Planet;Anna Marie Pyle;Anna Marie Pyle

  • ATP hydrolysis is required for DEAD-box protein recycling but not for duplex unwinding.

    Fei Liu;Andrea Putnam;Eckhard Jankowsky

  • Angiogenin-Cleaved tRNA Halves Interact with Cytochrome c, Protecting Cells from Apoptosis during Osmotic Stress

    Mridusmita Saikia;Raul Jobava;Marc Parisien;Andrea Putnam

  • Specificity and nonspecificity in RNA-protein interactions.

    Eckhard Jankowsky;Michael E. Harris

  • Stimulation of mammalian translation initiation factor eIF4A activity by a small molecule inhibitor of eukaryotic translation

    Marie Eve Bordeleau;James Matthews;Joanna M. Wojnar;Lisa Lindqvist

  • The DEAD-box protein Ded1 modulates translation by the formation and resolution of an eIF4F-mRNA complex.

    Angela Hilliker;Zhaofeng Gao;Eckhard Jankowsky;Roy Parker;Roy Parker

  • The DExH protein NPH-II is a processive and directional motor for unwinding RNA.

    Eckhard Jankowsky;Christian H. Gross;Stewart Shuman;Anna Marie Pyle;Anna Marie Pyle

  • Involvement of DEAD-box proteins in group I and group II intron splicing. Biochemical characterization of Mss116p, ATP hydrolysis-dependent and -independent mechanisms, and general RNA chaperone activity.

    Coralie Halls;Sabine Mohr;Mark Del Campo;Quansheng Yang

  • ATP- and ADP-Dependent Modulation of RNA Unwinding and Strand Annealing Activities by the DEAD-Box Protein DED1†

    Quansheng Yang;Eckhard Jankowsky

  • DEAD-box helicases as integrators of RNA, nucleotide and protein binding.

    Andrea A. Putnam;Eckhard Jankowsky

  • The DEAH-box protein PRP22 is an ATPase that mediates ATP-dependent mRNA release from the spliceosome and unwinds RNA duplexes.

    John D.O. Wagner;Eckhard Jankowsky;Anna Marie Pyle

  • DEAD-Box Proteins Unwind Duplexes by Local Strand Separation

    Quansheng Yang;Mark Del Campo;Alan M. Lambowitz;Eckhard Jankowsky

Frequent Co-Authors

Anna Marie Pyle
Anna Marie Pyle Yale University
Michael Harris
Michael Harris University of Florida
Alan M. Lambowitz
Alan M. Lambowitz The University of Texas at Austin
Jeremy N. Rich
Jeremy N. Rich University of Pittsburgh
Timothy W. Nilsen
Timothy W. Nilsen Case Western Reserve University
Carsten Müller-Tidow
Carsten Müller-Tidow University Hospital Heidelberg
Maria Hatzoglou
Maria Hatzoglou Case Western Reserve University
William C. Merrick
William C. Merrick Case Western Reserve University
Satoru Miyano
Satoru Miyano Tokyo Medical and Dental University

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