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Genetics

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78
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1700
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Molecular Biology

D-Index
78
Citations
22331
World Ranking
1079
National Ranking
560

Overview

Winfried Edelmann is affiliated with the Albert Einstein College of Medicine in the United States. Their research encompasses multiple fields within biochemistry, genetics, molecular biology, and medicine, with a particular focus on molecular biology and cancer research.

The scientist's work covers a range of specialized topics including:

  • Genetic factors in colorectal cancer
  • Cancer Genomics and Diagnostics
  • DNA Repair Mechanisms
  • Epigenetics and DNA Methylation
  • Genomics and Chromatin Dynamics
  • Cancer-related gene regulation
  • RNA modifications and cancer

Edelmann has contributed to several publications in prestigious venues. Frequent publication outlets include bioRxiv (Cold Spring Harbor Laboratory), Cancer Research, Nature, Gastroenterology, and Genes & Development.

Among recent papers authored or co-authored by Edelmann are:

  • "H1 histones control the epigenetic landscape by local chromatin compaction," 2020, Nature
  • "Recurrent Frameshift Neoantigen Vaccine Elicits Protective Immunity With Reduced Tumor Burden and Improved Overall Survival in a Lynch Syndrome Mouse Model," 2021, Gastroenterology
  • "Molecular structures and mechanisms of DNA break processing in mouse meiosis," 2020, Genes & Development
  • "Blockade of the immunosuppressive KIR2DL5/PVR pathway elicits potent human NK cell-mediated antitumor immunity," 2022, Journal of Clinical Investigation
  • "A CAG repeat threshold for therapeutics targeting somatic instability in Huntington's disease," 2024, Brain

Frequent collaborators in their research include Elena Tosti, Eduardo Vilar, Yongwei Zhang, Nan Deng, and Charles M. Bowen, each contributing to multiple co-authored works.

Edelmann's scientific contributions span both broad and specialized fields, with main studies in biochemistry, genetics, molecular biology, pathology, forensic medicine, cancer research, genetics, and immunology. This broad multidisciplinary approach aligns with their work focus on genetic and epigenetic mechanisms underlying cancer and other diseases.

Best Publications

  • Caveolin-1 Null Mice Are Viable but Show Evidence of Hyperproliferative and Vascular Abnormalities

    Babak Razani;Jeffery A. Engelman;Xiao Bo Wang;William Schubert

  • Meiotic Pachytene Arrest in MLH1-Deficient Mice

    Winfried Edelmann;Paula E Cohen;Michael Kane;Kirkland Lau

  • GFAP Is Necessary for the Integrity of CNS White Matter Architecture and Long-Term Maintenance of Myelination

    Wolfgang Liedtke;Winfried Edelmann;Phyllis L. Bieri;Fung Chow Chiu

  • A targeted chain-termination mutation in the mouse Apc gene results in multiple intestinal tumors

    R Fodde;W Edelmann;K Yang;C van Leeuwen

  • Somatic Inactivation of Pkd2 Results in Polycystic Kidney Disease

    Guanqing Wu;Vivette D'Agati;Yiqiang Cai;Glen Markowitz

  • Caveolin-3 Null Mice Show a Loss of Caveolae, Changes in the Microdomain Distribution of the Dystrophin-Glycoprotein Complex, and T-tubule Abnormalities

    Ferruccio Galbiati;Jeffrey A. Engelman;Daniela Volonte;Xiao Lan Zhang

  • MutS homolog 4 localization to meiotic chromosomes is required for chromosome pairing during meiosis in male and female mice

    Burkhard Kneitz;Paula E. Cohen;Elena Avdievich;Liyin Zhu

  • SLiCE: a novel bacterial cell extract-based DNA cloning method

    Yongwei Zhang;Uwe Werling;Winfried Edelmann

  • Gut Microbial Metabolism Drives Transformation of Msh2-Deficient Colon Epithelial Cells

    Antoaneta Belcheva;Thergiory Irrazabal;Susan J. Robertson;Catherine Streutker

  • Mammalian MutS homologue 5 is required for chromosome pairing in meiosis

    Winfried Edelmann;Paula E. Cohen;Burkhard Kneitz;Nena Winand

  • Mutation in the mismatch repair gene Msh6 causes cancer susceptibility

    Winfried Edelmann;Kan Yang;Asad Umar;Joerg Heyer

  • Cardiac defects and renal failure in mice with targeted mutations in Pkd2.

    Guanqing Wu;G. S. Markowitz;Li Li;V. D. D'agati

  • Caveolin-2-Deficient Mice Show Evidence of Severe Pulmonary Dysfunction without Disruption of Caveolae

    Babak Razani;Xiao Bo Wang;Jeffery A. Engelman;Michela Battista

  • APC-dependent suppression of colon carcinogenesis by PPARγ

    Geoffrey D. Girnun;Wendy M. Smith;Stavit Drori;Pasha Sarraf

  • Inactivation of Exonuclease 1 in mice results in DNA mismatch repair defects, increased cancer susceptibility, and male and female sterility

    Kaichun Wei;Alan B. Clark;Edmund Wong;Michael F. Kane

  • The murine N-ras gene is not essential for growth and development.

    Heywood Umanoff;Winfried Edelmann;Angel Pellicer;Raju Kucherlapati

  • Reduced Isotype Switching in Splenic B Cells from Mice Deficient in Mismatch Repair Enzymes

    Carol E. Schrader;Winfried Edelmann;Raju Kucherlapati;Janet Stavnezer

  • Apc1638T: a mouse model delineating critical domains of the adenomatous polyposis coli protein involved in tumorigenesis and development

    Ron Smits;Menno F. Kielman;Cor Breukel;Chris Zurcher

  • Haploinsufficiency of Flap endonuclease (Fen1) leads to rapid tumor progression

    Melanie Kucherlapati;Kan Yang;Mari Kuraguchi;Jie Zhao

  • Erratum: Gut microbial metabolism drives transformation of msh2-deficient colon epithelial cells (Cell (2014) 158 (288-299) )

    Antoaneta Belcheva;Thergiory Irrazabal;Susan J. Robertson;Catherine Streutker

Frequent Co-Authors

Raju Kucherlapati
Raju Kucherlapati Harvard University
Paula E. Cohen
Paula E. Cohen Cornell University
Matthew D. Scharff
Matthew D. Scharff Albert Einstein College of Medicine
Richard D. Kolodner
Richard D. Kolodner University of California, San Diego
Nevan J. Krogan
Nevan J. Krogan University of California, San Francisco
Thomas A. Kunkel
Thomas A. Kunkel National Institutes of Health
Anthony M. C. Brown
Anthony M. C. Brown Cornell University
Jeffrey W. Pollard
Jeffrey W. Pollard University of Edinburgh
Steven M. Lipkin
Steven M. Lipkin Weill Cornell Medicine
Roderick T. Bronson
Roderick T. Bronson Harvard University

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