D-Index & Metrics Best Publications

D-Index & Metrics

Discipline name D-index D-index (Discipline H-index) only includes papers and citation values for an examined discipline in contrast to General H-index which accounts for publications across all disciplines. Citations Publications World Ranking National Ranking
Genetics and Molecular Biology D-index 60 Citations 14,217 97 World Ranking 2376 National Ranking 1171

Overview

What is he best known for?

The fields of study he is best known for:

  • Gene
  • DNA
  • Mutation

Winfried Edelmann focuses on Molecular biology, Mutation, DNA mismatch repair, MSH2 and Null allele. His Molecular biology research is multidisciplinary, incorporating elements of Bacterial artificial chromosome, Homologous recombination, Carcinogenesis, Mutant and Adenomatous polyposis coli. His Mutation study combines topics from a wide range of disciplines, such as Myocyte, Gene targeting, Muscular dystrophy and Caveolin 3.

He interconnects Cancer research and Microsatellite instability in the investigation of issues within DNA mismatch repair. Winfried Edelmann combines subjects such as MLH1, Somatic hypermutation, MLH3 and MSH4 with his study of MSH2. The Null allele study combines topics in areas such as Germline mutation, Kidney, Autosomal dominant polycystic kidney disease, Haploinsufficiency and Stem cell.

His most cited work include:

  • Caveolin-1 Null Mice Are Viable but Show Evidence of Hyperproliferative and Vascular Abnormalities (1007 citations)
  • Meiotic Pachytene Arrest in MLH1-Deficient Mice (487 citations)
  • Somatic Inactivation of Pkd2 Results in Polycystic Kidney Disease (478 citations)

What are the main themes of his work throughout his whole career to date?

His scientific interests lie mostly in DNA mismatch repair, Molecular biology, Genetics, Cancer research and Carcinogenesis. DNA mismatch repair is often connected to Mutation in his work. Winfried Edelmann has included themes like Microsatellite instability, Frameshift mutation, Point mutation, Gene targeting and Base Pair Mismatch in his Molecular biology study.

Winfried Edelmann focuses mostly in the field of Cancer research, narrowing it down to matters related to Colorectal cancer and, in some cases, Pathology and Metastasis. His Carcinogenesis study combines topics in areas such as Tumor progression, Endocrinology, Adenomatous polyposis coli and Intestinal mucosa. His study explores the link between MSH2 and topics such as Germline mutation that cross with problems in Somatic cell.

He most often published in these fields:

  • DNA mismatch repair (36.63%)
  • Molecular biology (29.07%)
  • Genetics (27.33%)

What were the highlights of his more recent work (between 2014-2021)?

  • DNA mismatch repair (36.63%)
  • Cell biology (16.86%)
  • MSH2 (19.77%)

In recent papers he was focusing on the following fields of study:

His primary areas of study are DNA mismatch repair, Cell biology, MSH2, Cancer and Genetics. His DNA mismatch repair study is concerned with DNA repair in general. His studies deal with areas such as Meiosis, DNA damage, Mutation and Chromatin, Chromatin remodeling as well as Cell biology.

His work carried out in the field of MSH2 brings together such families of science as Molecular biology, Germline mutation, Genome and Lynch syndrome. His studies in Molecular biology integrate themes in fields like Intestinal mucosa and Microsatellite instability. Colorectal cancer, Chemotherapy, DNA Repair Deficiency and Small molecule is closely connected to Cancer research in his research, which is encompassed under the umbrella topic of Cancer.

Between 2014 and 2021, his most popular works were:

  • Minimal PU.1 reduction induces a preleukemic state and promotes development of acute myeloid leukemia (71 citations)
  • Genomic Landscape of Colorectal Mucosa and Adenomas (49 citations)
  • Chromatin remodeling enzyme Snf2h regulates embryonic lens differentiation and denucleation. (27 citations)

In his most recent research, the most cited papers focused on:

  • Gene
  • DNA
  • Mutation

His primary scientific interests are in Cell biology, MSH2, DNA mismatch repair, Cancer research and Chromatin. His Cell biology research incorporates themes from Histone, Chromatin remodeling, Epigenetics and Nucleosome. His MSH2 research is multidisciplinary, relying on both Mutation, Germline mutation and Lynch syndrome.

His Mutation study combines topics from a wide range of disciplines, such as Base excision repair, DNA repair, MutL Proteins, MSH3 and Trinucleotide repeat expansion. His Lynch syndrome research is multidisciplinary, incorporating perspectives in Molecular biology, Gene targeting and Microsatellite instability. His biological study spans a wide range of topics, including Cancer stem cell, Colorectal cancer, Transcription factor and Haematopoiesis.

This overview was generated by a machine learning system which analysed the scientist’s body of work. If you have any feedback, you can contact us here.

Best Publications

Caveolin-1 Null Mice Are Viable but Show Evidence of Hyperproliferative and Vascular Abnormalities

Babak Razani;Jeffery A. Engelman;Xiao Bo Wang;William Schubert.
Journal of Biological Chemistry (2001)

1312 Citations

Meiotic Pachytene Arrest in MLH1-Deficient Mice

Winfried Edelmann;Paula E Cohen;Michael Kane;Kirkland Lau.
Cell (1996)

666 Citations

A targeted chain-termination mutation in the mouse Apc gene results in multiple intestinal tumors

R Fodde;W Edelmann;K Yang;C van Leeuwen.
Proceedings of the National Academy of Sciences of the United States of America (1994)

621 Citations

GFAP Is Necessary for the Integrity of CNS White Matter Architecture and Long-Term Maintenance of Myelination

Wolfgang Liedtke;Winfried Edelmann;Phyllis L. Bieri;Fung Chow Chiu.
Neuron (1996)

563 Citations

Somatic Inactivation of Pkd2 Results in Polycystic Kidney Disease

Guanqing Wu;Vivette D'Agati;Yiqiang Cai;Glen Markowitz.
Cell (1998)

552 Citations

Caveolin-3 Null Mice Show a Loss of Caveolae, Changes in the Microdomain Distribution of the Dystrophin-Glycoprotein Complex, and T-tubule Abnormalities

Ferruccio Galbiati;Jeffrey A. Engelman;Daniela Volonte;Xiao Lan Zhang.
Journal of Biological Chemistry (2001)

517 Citations

MutS homolog 4 localization to meiotic chromosomes is required for chromosome pairing during meiosis in male and female mice

Burkhard Kneitz;Paula E. Cohen;Elena Avdievich;Liyin Zhu.
Genes & Development (2000)

469 Citations

Mammalian MutS homologue 5 is required for chromosome pairing in meiosis

Winfried Edelmann;Paula E. Cohen;Burkhard Kneitz;Nena Winand.
Nature Genetics (1999)

442 Citations

SLiCE: a novel bacterial cell extract-based DNA cloning method

Yongwei Zhang;Uwe Werling;Winfried Edelmann.
Nucleic Acids Research (2012)

406 Citations

Mutation in the mismatch repair gene Msh6 causes cancer susceptibility

Winfried Edelmann;Kan Yang;Asad Umar;Joerg Heyer.
Cell (1997)

400 Citations

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