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Anthony M. C. Brown

Anthony M. C. Brown

D-Index & Metrics

Molecular Biology

D-Index
62
Citations
14344
World Ranking
1849
National Ranking
922

Overview

Anthony M. C. Brown is affiliated with Cornell University in the United States. Their research primarily focuses on the field of Medicine, with specific contributions to Oncology, Pathology and Forensic Medicine, and Molecular Biology. The core topics explored in their work include Cancer Cells and Metastasis, Genetic Factors in Colorectal Cancer, and Wnt/β-catenin Signaling in Development and Cancer.

Among their recent publications are:

  • Disruption of the crypt niche promotes outgrowth of mutated colorectal tumor stem cells, 2022, published in JCI Insight
  • Correction: Wnt signaling promotes oncogenic transformation by inhibiting c-Myc-induced apoptosis, 2021, published in The Journal of Cell Biology

These papers contribute to understanding the cellular environment and genetic pathways involved in cancer development, with a focus on colorectal tumor biology and signaling pathways that regulate oncogenic transformation.

Their frequent collaborators include:

  • Stefan Klingler
  • Kuo-Shun Hsu
  • Guoqiang Hua
  • M. Laura Martín
  • Mohammad Adileh

Anthony M. C. Brown's work has been published predominantly in venues such as:

  • JCI Insight
  • The Journal of Cell Biology

This reflects a focus on journals relevant to cell biology and medical insight, aligning with their research interests in cellular mechanisms and oncological processes.

Their research addresses key aspects of colorectal cancer biology, particularly the interactions within the crypt niche that influence mutated tumor stem cells and the role of Wnt signaling in cancer cell apoptosis and oncogenic transformation.

Best Publications

  • Transformation by Wnt family proteins correlates with regulation of beta-catenin.

    Hiroyuki Shimizu;Martin A. Julius;Marianna Giarré;Zhili Zheng

  • A new nomenclature for int-1 and related genes: The Wnt gene family

    R Nusse;A Brown;J Papkoff;P Scambler

  • Activation of pS2 gene transcription is a primary response to estrogen in the human breast cancer cell line MCF-7.

    Anthony M. C. Brown;Jean-Marc Jeltsch;Margo Roberts;Pierre Chambon

  • Cyclooxygenase-2: a target for the prevention and treatment of breast cancer.

    L. R. Howe;K. Subbaramaiah;A. M C Brown;Andrew Dannenberg

  • Wnt-1 regulation of connexin43 in cardiac myocytes

    Zhaowei Ai;Avi Fischer;David C. Spray;Anthony M.C. Brown

  • Wnt Signaling and Breast Cancer

    Louise R. Howe;Anthony M.C. Brown

  • An RNAi-based chemical genetic screen identifies three small-molecule inhibitors of the Wnt/wingless signaling pathway

    Foster C. Gonsalves;Keren Klein;Brittany B. Carson;Shauna Katz

  • The proto-oncogene int-1 encodes a secreted protein associated with the extracellular matrix.

    R. S. Bradley;A. M. C. Brown

  • Wnt proteins in mammary development and cancer

    Keith R. Brennan;Anthony M. C. Brown

  • Expression of Wnt-1 in PC12 cells results in modulation of plakoglobin and E-cadherin and increased cellular adhesion.

    Roger S. Bradley;Pamela Cowin;Anthony M. C. Brown

  • Twist Is Up-Regulated in Response to Wnt1 and Inhibits Mouse Mammary Cell Differentiation

    Louise R Howe;Osamu Watanabe;James Leonard;Anthony M C Brown

  • Haploinsufficiency of Flap endonuclease (Fen1) leads to rapid tumor progression

    Melanie Kucherlapati;Kan Yang;Mari Kuraguchi;Jie Zhao

  • Wnt-5a and Wnt-7a are expressed in the developing chick limb bud in a manner suggesting roles in pattern formation along the proximodistal and dorsoventral axes

    Caroline N. Dealy;Adam Roth;Deborah Ferrari;Anthony M.C. Brown

  • Transcriptional activation of cyclooxygenase-2 in Wnt-1-transformed mouse mammary epithelial cells.

    Louise R. Howe;Louise R. Howe;Kotha Subbaramaiah;Kotha Subbaramaiah;Wen Jing Chung;Wen Jing Chung;Andrew J. Dannenberg

  • Wnt signaling promotes oncogenic transformation by inhibiting c-Myc–induced apoptosis

    Zongbing You;Daniel Saims;Shaoqiong Chen;Zhaocheng Zhang

  • Celecoxib, a selective cyclooxygenase 2 inhibitor, protects against human epidermal growth factor receptor 2 (HER-2)/neu-induced breast cancer.

    Louise R Howe;Kotha Subbaramaiah;Kotha Subbaramaiah;Jay Patel;Jaime L Masferrer

  • Wnt5a signaling induces proliferation and survival of endothelial cells in vitro and expression of MMP-1 and Tie-2

    T. Néstor H Masckauchán;Dritan Agalliu;Marina Vorontchikhina;Audrey Ahn

  • INHIBITION OF CHONDROGENESIS BY WNT GENE EXPRESSION IN VIVO AND IN VITRO

    Julie A. Rudnicki;Anthony M.C. Brown

  • Clonal analysis of cardiac morphogenesis in the chicken embryo using a replication-defective retrovirus: I. Formation of the ventricular myocardium.

    T. Mikawa;A. Borisov;A. M. C. Brown;D. A. Fischman

  • Caveolin-1 Expression Inhibits Wnt/β-Catenin/Lef-1 Signaling by Recruiting β-Catenin to Caveolae Membrane Domains

    Ferruccio Galbiati;Daniela Volonte;Anthony M.C. Brown;Anthony M.C. Brown;David E. Weinstein

Frequent Co-Authors

Kotha Subbaramaiah
Kotha Subbaramaiah Cornell University
Harold E. Varmus
Harold E. Varmus Cornell University
Andrew J. Dannenberg
Andrew J. Dannenberg Cornell University
Winfried Edelmann
Winfried Edelmann Albert Einstein College of Medicine
Raju Kucherlapati
Raju Kucherlapati Harvard University
Jan Kitajewski
Jan Kitajewski Columbia University
Takashi Mikawa
Takashi Mikawa University of California, San Francisco
George Coupland
George Coupland Max Planck Society
Richard D. Kolodner
Richard D. Kolodner University of California, San Diego
Anne M. Bowcock
Anne M. Bowcock Icahn School of Medicine at Mount Sinai

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