World's Best Scientists 2026 revealed!

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Chemistry

D-Index
50
Citations
8312
World Ranking
14455
National Ranking
3711

Research.com Recognitions

  • 2006 - Fellow of the American Association for the Advancement of Science (AAAS)
  • 1971 - Fellow of John Simon Guggenheim Memorial Foundation

Overview

Jack F. Kirsch is affiliated with the University of California, Berkeley in the United States. Their research primarily focuses on medicine, with specific work in psychiatry and mental health, pathology and forensic medicine, and physiology.

The scientist's work frequently addresses topics such as migraine and headache studies, trigeminal neuralgia and treatments, and sympathectomy and hyperhidrosis treatments.

Recent publications include:

  • Review of Tolerability of Fremanezumab for Episodic and Chronic Migraine, 2023, Neuropsychiatric Disease and Treatment

Jack F. Kirsch has coauthored papers with:

  • Shane Root
  • Kevin Ahn
  • Justin Hoskin

The main venue for their publications is Neuropsychiatric Disease and Treatment.

Jack F. Kirsch has received fellowships including:

  • Fellow of the American Association for the Advancement of Science (AAAS), 2006
  • Fellow of John Simon Guggenheim Memorial Foundation, 1971

Best Publications

  • Pyridoxal phosphate enzymes: mechanistic, structural, and evolutionary considerations.

    Andrew C. Eliot;Jack F. Kirsch

  • Direct Bronsted analysis of the restoration of activity to a mutant enzyme by exogenous amines

    Michael D. Toney;Jack F. Kirsch

  • Ancestral lysozymes reconstructed, neutrality tested, and thermostability linked to hydrocarbon packing.

    Bruce A. Malcolm;Keith P. Wilson;Brian W. Matthews;Jack F. Kirsch;Jack F. Kirsch

  • Site-directed mutagenesis of the catalytic residues Asp-52 and Glu-35 of chicken egg white lysozyme

    B A Malcolm;S Rosenberg;M J Corey;J S Allen

  • Investigation of diffusion-limited rates of chymotrypsin reactions by viscosity variation.

    Antoon C. Brouwer;Jack F. Kirsch

  • Energetic analysis of an antigen/antibody interface: Alanine scanning mutagenesis and double mutant cycles on the hyhel‐10/lysozyme interaction

    Jaume Pons;Arvind Rajpal;Jack F. Kirsch

  • Fractional diffusion-limited component of reactions catalyzed by acetylcholinesterase.

    Michael Bazelyansky;Ellen Robey;Jack F. Kirsch

  • Nonlinear Structure-Reactivity Correlations. The Imidazole-Catalyzed Hydrolysis of Esters

    Jack F. Kirsch;William P. Jencks

  • Redesign of the substrate specificity of Escherichia coli aspartate aminotransferase to that of Escherichia coli tyrosine aminotransferase by homology modeling and site-directed mutagenesis.

    James J. Onuffer;Jack F. Kirsch

  • Structure of 1-aminocyclopropane-1-carboxylate synthase, a key enzyme in the biosynthesis of the plant hormone ethylene.

    Guido Capitani;Erhard Hohenester;Liang Feng;Paola Storici

  • Substrate Specificity of the Escherichia coli Outer Membrane Protease OmpT

    John D. McCarter;Daren Stephens;Kevin Shoemaker;Steve Rosenberg

  • The Kinetics of the Papain-Catalyzed Hydrolysis of Esters of Carbobenzoxyglycine. Evidence for an Acyl-Enzyme Intermediate*

    Jack F. Kirsch;Mona Igelström

  • Role of arginine-292 in the substrate specificity of aspartate aminotransferase as examined by site-directed mutagenesis.

    Ciaran N. Cronin;Jack F. Kirsch

  • Lysine 258 in aspartate aminotransferase: enforcer of the Circe effect for amino acid substrates and general-base catalyst for the 1,3-prototropic shift.

    Michael D. Toney;Jack F. Kirsch

  • Base Catalysis of Imidazole Catalysis of Ester Hydrolysis

    Jack F. Kirsch;William P. Jencks

  • How Does an Enzyme Evolved In vitro Compare to Naturally Occurring Homologs Possessing the Targeted Function? Tyrosine Aminotransferase from Aspartate Aminotransferase

    Steven C. Rothman;Jack F. Kirsch

  • Thermal stability determinants of chicken egg-white lysozyme core mutants: hydrophobicity, packing volume, and conserved buried water molecules.

    P Shih;D R Holland;J F Kirsch;J F Kirsch

  • Expression of apple 1-aminocyclopropane-1-carboxylate synthase in Escherichia coli: kinetic characterization of wild-type and active-site mutant forms.

    Malcolm F. White;John Vasquez;Shang F. Yang;Jack F. Kirsch

  • Diffusion-limited component of reactions catalyzed by Bacillus cereus beta-lactamase I.

    Larry W. Hardy;Jack F. Kirsch

  • Active site prediction using evolutionary and structural information

    Sriram Sankararaman;Fei Sha;Jack F. Kirsch;Michael I. Jordan

  • Site-directed mutagenesis of aspartate aminotransferase from E. coli.

    Bruce A. Malcolm;Jack F. Kirsch

  • The tyrosine-225 to phenylalanine mutation of Escherichia coli aspartate aminotransferase results in an alkaline transition in the spectrophotometric and kinetic pKa values and reduced values of both kcat and Km.

    Jonathan M. Goldberg;Ronald V. Swanson;Harris S. Goodman;Jack F. Kirsch

Frequent Co-Authors

Michael D. Toney
Michael D. Toney University of California, Davis
Steven E. Brenner
Steven E. Brenner University of California, Berkeley
Johan N. Jansonius
Johan N. Jansonius University of Basel
Steven A. Rosenberg
Steven A. Rosenberg National Institutes of Health
James M. Berger
James M. Berger Johns Hopkins University
Tracy M. Handel
Tracy M. Handel University of Montana
Markus G. Grütter
Markus G. Grütter University of Zurich
Michael B. Eisen
Michael B. Eisen University of California, Berkeley
Allan C. Wilson
Allan C. Wilson University of California, Berkeley
Robert A. Bonomo
Robert A. Bonomo Case Western Reserve University

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