World's Best Scientists 2026 revealed!

D-Index & Metrics

Chemistry

D-Index
58
Citations
10922
World Ranking
10717
National Ranking
206

Biology and Biochemistry

D-Index
59
Citations
11084
World Ranking
12681
National Ranking
225

Overview

Philipp Christen is affiliated with the University of Zurich in Switzerland. Their research spans several key areas in biochemistry, genetics, molecular biology, and medicine, with a significant focus on microbiology-related fields. The scientist's work primarily deals with infectious diseases, food science, biotechnology, and genetics. Their research topics cover bacterial genetics, microbial metabolic engineering, gut microbiota and health, antimicrobial resistance, and epidemiology of pathogens such as Salmonella and Campylobacter.

Their publication record includes contributions to various journals, with several papers published in prestigious venues such as Nature Communications, Cell Host & Microbe, PLoS Biology, Microbiology Spectrum, and Gut Microbes. The most frequently appearing journals in their portfolio are Nature Communications and Cell Host & Microbe.

Recent publications by Philipp Christen include:

  • Generation of an Escherichia coli strain growing on methanol via the ribulose monophosphate cycle, 2022, Nature Communications
  • Salmonella Typhimurium screen identifies shifts in mixed-acid fermentation during gut colonization, 2024, Cell Host & Microbe
  • The microbiota conditions a gut milieu that selects for wild-type Salmonella Typhimurium virulence, 2023, PLoS Biology
  • C-di-AMP levels modulate Staphylococcus aureus cell wall thickness, response to oxidative stress, and antibiotic resistance and tolerance, 2023, Microbiology Spectrum
  • Sublethal systemic LPS in mice enables gut-luminal pathogens to bloom through oxygen species-mediated microbiota inhibition, 2025, Nature Communications

Philipp Christen has collaborated frequently with several scientists, including Patrick Kiefer, Julia A. Vorholt, Wolf-Dietrich Hardt, Bidong D. Nguyen, and Manja Barthel. These collaborations reflect a network of work spanning microbiology, infectious diseases, and molecular biology.

Their research topics often address:

  • Salmonella and Campylobacter epidemiology
  • Gut microbiota and health
  • Microbial metabolic engineering and bioproduction
  • Bacterial genetics and biotechnology
  • Clostridium difficile and Clostridium perfringens research
  • Antimicrobial resistance in Staphylococcus
  • Gene regulatory network analysis

Philipp Christen's work contributes to understanding bacterial pathogens, their interactions with the host microbiota, and mechanisms underlying antibiotic resistance and bacterial metabolism. The focus on metabolic engineering and gene regulatory networks suggests an integrative approach combining genetics and systems biology to address challenges in infectious diseases and biotechnology.

Best Publications

  • Mechanism of action of aspartate aminotransferase proposed on the basis of its spatial structure.

    Jack F. Kirsch;Gregor Eichele;Geoffrey C. Ford;Michael G. Vincent

  • Kinetics of Molecular Chaperone Action

    Daniel Schmid;Antonio Baici;Heinz Gehring;Philipp Christen

  • Aminotransferases: demonstration of homology and division into evolutionary subgroups

    Perdeep K. Mehta;Terence I. Hale;Philipp Christen

  • Evolutionary relationships among pyridoxal‐5′‐phosphate‐dependent enzymes

    Frederick W. Alexander;Erika Sandmeier;Perdeep K. Mehta;Philipp Christen

  • Heavy Metals and Metalloids As a Cause for Protein Misfolding and Aggregation

    Markus J. Tamás;Sandeep K. Sharma;Sebastian Ibstedt;Therese Jacobson

  • The molecular evolution of pyridoxal-5'-phosphate-dependent enzymes.

    Perdeep K. Mehta;Philipp Christen

  • Multiple evolutionary origin of pyridoxal-5′-phosphate-dependent amino acid decarboxylases

    Erika Sandmeier;Terence I. Hale;Philipp Christen

  • Demonstration of the ethylmalonyl-CoA pathway by using 13C metabolomics

    Rémi Peyraud;Patrick Kiefer;Philipp Christen;Stephane Massou

  • Heavy metal ions are potent inhibitors of protein folding

    Sandeep K. Sharma;Pierre Goloubinoff;Philipp Christen

  • The kinetic parameters and energy cost of the Hsp70 chaperone as a polypeptide unfoldase

    Sandeep K Sharma;Paolo De Los Rios;Philipp Christen;Ariel Lustig

  • From cofactor to enzymes. The molecular evolution of pyridoxal‐5′‐phosphate‐dependent enzymes

    Philipp Christen;Perdeep K. Mehta

  • Cytoplasmic aspartate aminotransferase: syncatalytic sulfhydryl group modification.

    Walter Birchmeier;Kenneth J. Wilson;Philipp Christen

  • Evolutionary relationships among aminotransferases

    Perdeep K. Mehta;Terence I. Hale;Philipp Christen

  • Arsenite interferes with protein folding and triggers formation of protein aggregates in yeast.

    Therese Jacobson;Clara Navarrete;Sandeep K. Sharma;Theodora C. Sideri

  • Mechanism of the targeting action of DnaJ in the DnaK molecular chaperone system.

    Wanjiang Han;Philipp Christen

  • The power stroke of the DnaK/DnaJ/GrpE molecular chaperone system

    Ezra V. Pierpaoli;Erika Sandmeier;Antonio Baici;Hans-Joachim Schönfeld

  • Disaggregating chaperones: an unfolding story.

    Sandeep K. Sharma;Philipp Christen;Pierre Goloubinoff

  • Reversible Thermal Transition in GrpE, the Nucleotide Exchange Factor of the DnaK Heat-Shock System

    John P.A. Grimshaw;Ilian Jelesarov;Hans-Joachim Schönfeld;Philipp Christen

  • Control of the DnaK Chaperone Cycle by Substoichiometric Concentrations of the Co-chaperones DnaJ and GrpE *

    Ezra V. Pierpaoli;Erika Sandmeier;Hans-Joachim Schönfeld;Philipp Christen

  • Isolation, crystallization and preliminary crystallographic data of aspartate aminotransferase from chicken heart mitochondria☆

    H. Gehring;P. Christen;G. Eichele;M. Glor

Frequent Co-Authors

Johan N. Jansonius
Johan N. Jansonius University of Basel
Peter Sonderegger
Peter Sonderegger University of Zurich
Sunil Kochhar
Sunil Kochhar Nestlé (Switzerland)
Pierre Goloubinoff
Pierre Goloubinoff University of Lausanne
James F. Riordan
James F. Riordan Harvard University
Miquel Coll
Miquel Coll Spanish National Research Council
Jean-Charles Portais
Jean-Charles Portais Federal University of Toulouse Midi-Pyrénées
Michael Huber
Michael Huber University of Zurich
Walter Birchmeier
Walter Birchmeier Max Delbrück Center for Molecular Medicine

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