World's Best Scientists 2026 revealed!

D-Index & Metrics

Molecular Biology

D-Index
120
Citations
90855
World Ranking
253
National Ranking
148

Research.com Recognitions

  • 2010 - Member of the National Academy of Sciences
  • 2001 - Fellow of the American Academy of Arts and Sciences
  • 1997 - Royal Netherlands Academy of Arts and Sciences

Overview

Roel Nusse is affiliated with Stanford University in the United States and conducts research primarily in the field of Biochemistry, Genetics and Molecular Biology. Their work encompasses several subfields, including Molecular Biology, Hepatology, Genetics, Surgery, and Cell Biology.

The scientist's research topics cover areas such as:

  • Epigenetics and DNA Methylation
  • Liver physiology and pathology
  • Fibroblast Growth Factor Research
  • Wnt/β-catenin signaling in development and cancer
  • Pluripotent Stem Cells Research
  • Single-cell and spatial transcriptomics
  • Cancer-related gene regulation

Roel Nusse has contributed to several recent papers, including:

  • "A single-cell transcriptomic atlas characterizes ageing tissues in the mouse" (2020, Nature)
  • "The Wnt Pathway: From Signaling Mechanisms to Synthetic Modulators" (2022, Annual Review of Biochemistry)
  • "Molecular hallmarks of heterochronic parabiosis at single-cell resolution" (2022, Nature)
  • "Pituitary stem cells produce paracrine WNT signals to control the expansion of their descendant progenitor cells" (2021, eLife)
  • "Wnt signaling regulates hepatocyte cell division by a transcriptional repressor cascade" (2022, Proceedings of the National Academy of Sciences)

Frequent co-authors collaborating with Roel Nusse include:

  • Matt Fish
  • Peng Wu
  • Teni Anbarchian
  • Norma Neff
  • Yinhua Jin

Their publications have appeared in various scientific venues, with the most frequent including:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Nature
  • eLife
  • Proceedings of the National Academy of Sciences
  • Nature Communications

Roel Nusse has received several awards throughout their career. These include:

  • Member of the National Academy of Sciences (2010)
  • Fellow of the American Academy of Arts and Sciences (2001)
  • Royal Netherlands Academy of Arts and Sciences (1997)

Best Publications

  • The Wnt signaling pathway in development and disease.

    Catriona Y. Logan;Roel Nusse

  • Wnt/β-catenin signaling and disease.

    Hans Clevers;Roel Nusse

  • Wnt/β-Catenin Signaling, Disease, and Emerging Therapeutic Modalities.

    Roel Nusse;Hans Clevers

  • Wnt signaling: a common theme in animal development

    Ken M. Cadigan;Roel Nusse

  • Convergence of Wnt, ß-Catenin, and Cadherin Pathways

    W. James Nelson;Roel Nusse

  • Wnt proteins are lipid-modified and can act as stem cell growth factors

    Karl Willert;Jeffrey D. Brown;Esther Danenberg;Andrew W. Duncan

  • A role for Wnt signalling in self-renewal of haematopoietic stem cells

    Tannishtha Reya;Andrew W. Duncan;Laurie Ailles;Jos Domen

  • MECHANISMS OF WNT SIGNALING IN DEVELOPMENT

    Andreas Wodarz;Roel Nusse

  • Many tumors induced by the mouse mammary tumor virus contain a provirus integrated in the same region of the host genome.

    Roel Nusse;Harold E. Varmus

  • A new member of the frizzled family from Drosophila functions as a Wingless receptor.

    Purnima Bhanot;Marcel Brink;Cindy Harryman Samos;Jen Chih Hsieh

  • Wnt Signaling: Multiple Pathways, Multiple Receptors, and Multiple Transcription Factors

    Michael D. Gordon;Roel Nusse

  • Purified Wnt5a Protein Activates or Inhibits β-Catenin–TCF Signaling Depending on Receptor Context

    Amanda J Mikels;Roel Nusse

  • Towards an integrated view of Wnt signaling in development.

    Renée van Amerongen;Roel Nusse

  • An integral program for tissue renewal and regeneration: Wnt signaling and stem cell control

    Hans Clevers;Kyle M. Loh;Roel Nusse

  • The Drosophila homolog of the mouse mammary oncogene int-1 is identical to the segment polarity gene wingless.

    Frans Rijsewijk;Marcus Schuermann;Els Wagenaar;Paul Parren

  • Wnt signaling in disease and in development

    Roel Nusse

  • Neu-protein overexpression in breast cancer. Association with comedo-type ductal carcinoma in situ and limited prognostic value in stage II breast cancer.

    van de Vijver Mj;Peterse Jl;Mooi Wj;Wisman P

  • Construction of transgenic Drosophila by using the site-specific integrase from phage phiC31.

    Amy C Groth;Matthew Fish;Roel Nusse;Michele P Calos

  • Ablation of insulin-producing neurons in flies: growth and diabetic phenotypes.

    Eric J. Rulifson;Seung K. Kim;Roel Nusse

  • β-catenin: a key mediator of Wnt signaling

    Karl Willert;Roel Nusse

Frequent Co-Authors

Karl Willert
Karl Willert University of California, San Diego
John Klingensmith
John Klingensmith Duke University
Harold E. Varmus
Harold E. Varmus Cornell University
Jill A. Helms
Jill A. Helms Stanford University
Norbert Perrimon
Norbert Perrimon Harvard University
Irving L. Weissman
Irving L. Weissman Stanford University
Hans Clevers
Hans Clevers Hubrecht Institute for Developmental Biology and Stem Cell Research
Patricia C. Salinas
Patricia C. Salinas University College London
Jeremy Nathans
Jeremy Nathans Johns Hopkins University School of Medicine
Johannes L. Peterse
Johannes L. Peterse Antoni van Leeuwenhoek Hospital

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