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D-Index & Metrics

Molecular Biology

D-Index
71
Citations
37437
World Ranking
1342
National Ranking
681

Research.com Recognitions

  • 2011 - Fellow of the American Association for the Advancement of Science (AAAS)

Overview

Xi He is affiliated with Boston Children's Hospital in the United States and has contributed extensively to the fields of biochemistry, genetics, molecular biology, and medicine. Their research focuses predominantly on molecular biology, oncology, genetics, cell biology, and cellular and molecular neuroscience.

The main topics covered in Xi He's research include:

  • Wnt/β-catenin signaling in development and cancer
  • Cancer-related gene regulation
  • Cancer cells and metastasis
  • Genetics and neurodevelopmental disorders
  • Epigenetics and DNA methylation
  • Single-cell and spatial transcriptomics
  • Pregnancy and preeclampsia studies

Xi He has published several papers in notable venues. Some recent examples include:

  • Overcoming Wnt-β-catenin dependent anticancer therapy resistance in leukaemia stem cells, 2020, Nature Cell Biology
  • Volumetric Compression Induces Intracellular Crowding to Control Intestinal Organoid Growth via Wnt/β-Catenin Signaling, 2020, Cell Stem Cell
  • Wnt signaling activates MFSD2A to suppress vascular endothelial transcytosis and maintain blood-retinal barrier, 2020, Science Advances
  • Single-molecule dynamics of Dishevelled at the plasma membrane and Wnt pathway activation, 2020, Proceedings of the National Academy of Sciences
  • Aberrant Cholesterol Metabolism and Wnt/β-Catenin Signaling Coalesce via Frizzled5 in Supporting Cancer Growth, 2022, Advanced Science

Frequent publication venues for Xi He include:

  • Blood (6 publications)
  • Current Biology (2 publications)
  • eLife (2 publications)
  • bioRxiv (Cold Spring Harbor Laboratory) (2 publications)
  • Nature Cell Biology (1 publication)

Xi He has collaborated with various researchers, with frequent coauthors including:

  • Linheng Li (18 collaborations)
  • Xinjun Zhang (9 collaborations)
  • Jay R. Unruh (9 collaborations)
  • Maorong Chen (8 collaborations)
  • Ren Sheng (8 collaborations)

In 2011, Xi He was recognized as a Fellow of the American Association for the Advancement of Science (AAAS).

Best Publications

  • Wnt/β-catenin signaling: components, mechanisms, and diseases

    Bryan T. MacDonald;Keiko Tamai;Xi He

  • Control of β-Catenin Phosphorylation/Degradation by a Dual-Kinase Mechanism

    Chunming Liu;Yiming Li;Mikhail Semenov;Chun Han

  • LDL-receptor-related proteins in Wnt signal transduction

    Keiko Tamai;Mikhall Semenov;Yolchi Kato;Rebecca Spokony

  • TSC2 Integrates Wnt and Energy Signals via a Coordinated Phosphorylation by AMPK and GSK3 to Regulate Cell Growth

    Ken Inoki;Hongjiao Ouyang;Tianqing Zhu;Charlotta Lindvall

  • LDL receptor-related proteins 5 and 6 in Wnt/β-catenin signaling: Arrows point the way

    Xi He;Mikhail Semenov;Keiko Tamai;Xin Zeng

  • BMP signaling inhibits intestinal stem cell self-renewal through suppression of Wnt–β-catenin signaling

    Xi C. He;Jiwang Zhang;Wei Gang Tong;Ossama Tawfik

  • A dual-kinase mechanism for Wnt co-receptor phosphorylation and activation.

    Xin Zeng;Keiko Tamai;Brad Doble;Shitao Li

  • Wnt/Frizzled Activation of Rho Regulates Vertebrate Gastrulation and Requires a Novel Formin Homology Protein Daam1

    Raymond Habas;Yoichi Kato;Xi He

  • SOST Is a Ligand for LRP5/LRP6 and a Wnt Signaling Inhibitor

    Mikhail Semënov;Keiko Tamai;Xi He

  • Expression of a large family of POU-domain regulatory genes in mammalian brain development.

    Xi He;Maurice N. Treacy;Donna M. Simmons;Donna M. Simmons;Holly A. Ingraham;Holly A. Ingraham

  • Head inducer Dickkopf-1 is a ligand for Wnt coreceptor LRP6

    Mikhail V Semënov;Keiko Tamai;Barbara K Brott;Michael Kühl

  • A Mechanism for Wnt Coreceptor Activation

    Keiko Tamai;Xin Zeng;Chunming Liu;Xinjun Zhang

  • Destabilization of beta catenin by mutations in presenilin-1 potentiates neuronal apoptosis

    Zhuohua Zhang;H. Hartmann;Viet Minh Do;D. Abramowski

  • Coactivation of Rac and Rho by Wnt/Frizzled signaling is required for vertebrate gastrulation

    Raymond Habas;Igor B. Dawid;Xi He

  • Frizzled and LRP5/6 receptors for Wnt/β-catenin signaling.

    Bryan T. MacDonald;Xi He

  • Initiation of Wnt signaling: control of Wnt coreceptor Lrp6 phosphorylation/activation via frizzled, dishevelled and axin functions

    Xin Zeng;He Huang;Keiko Tamai;Xinjun Zhang

  • Wnt/β-catenin signaling: new (and old) players and new insights

    He Huang;Xi He

  • β-Trcp couples β-catenin phosphorylation-degradation and regulates Xenopus axis formation

    Chunming Liu;Yoichi Kato;Zhuohua Zhang;Viet Minh Do

  • Transcriptional accessibility for genes of multiple tissues and hematopoietic lineages is hierarchically controlled during early hematopoiesis

    Koichi Akashi;Xi He;Xi He;Xi He;Jie Chen;Jie Chen;Jie Chen;Hiromi Iwasaki;Hiromi Iwasaki;Hiromi Iwasaki

  • Lrp5 functions in bone to regulate bone mass

    Yajun Cui;Paul J Niziolek;Paul J Niziolek;Bryan T MacDonald;Cassandra R Zylstra

Frequent Co-Authors

Linheng Li
Linheng Li Stowers Institute for Medical Research
James R. Woodgett
James R. Woodgett Lunenfeld-Tanenbaum Research Institute
Matthew L. Warman
Matthew L. Warman Boston Children's Hospital
Koichi Akashi
Koichi Akashi Kyushu University
Bart O. Williams
Bart O. Williams Van Andel Institute
Joseph E. Italiano
Joseph E. Italiano Boston Children's Hospital
Anthony Wynshaw-Boris
Anthony Wynshaw-Boris Case Western Reserve University
Robert E. Kingston
Robert E. Kingston Harvard University
Igor B. Dawid
Igor B. Dawid National Institutes of Health
Norbert Perrimon
Norbert Perrimon Harvard University

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