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Gunnar Schulte

Gunnar Schulte

D-Index & Metrics

Biology and Biochemistry

D-Index
51
Citations
9519
World Ranking
17155
National Ranking
268

Overview

Gunnar Schulte is affiliated with the Karolinska Institute in Sweden and contributes extensively to the field of biochemistry, genetics, and molecular biology. Their research primarily focuses on receptor mechanisms and signaling, with particular interest in Wnt/β-catenin signaling, neuropeptides and animal physiology, and cancer-related gene regulation.

The scientist's recent publications span several notable journals and cover diverse aspects of cellular signaling and receptor biology. Key publications include:

  • Quantitative assessment of constitutive G protein-coupled receptor activity with BRET-based G protein biosensors (2021, Science Signaling)
  • Structural insight into small molecule action on Frizzleds (2020, Nature Communications)
  • Cryo-EM structure of constitutively active human Frizzled 7 in complex with heterotrimeric Gs (2021, Cell Research)
  • eGFP-tagged Wnt-3a enables functional analysis of Wnt trafficking and signaling and kinetic assessment of Wnt binding to full-length Frizzled (2020, Journal of Biological Chemistry)
  • Quantitative Profiling of WNT-3A Binding to All Human Frizzled Paralogues in HEK293 Cells by NanoBiT/BRET Assessments (2021, ACS Pharmacology & Translational Science)

Frequent co-authors in their work include Lukas Grätz, Paweł Kozielewicz, Hannes Schihada, Jan Voss, and Ainoleena Turku, indicating active collaboration within the research community.

The scientist has published regularly in several journals, with a strong presence in:

  • Nature Communications
  • British Journal of Pharmacology
  • bioRxiv (Cold Spring Harbor Laboratory)
  • Journal of Biological Chemistry
  • Pharmacological Reviews

Gunnar Schulte's primary domains of study focus predominantly on molecular biology, with additional research contributions in cellular and molecular neuroscience, oncology, cell biology, and social psychology. Their work addresses significant topics such as protein kinase regulation and GTPase signaling, epigenetics and DNA methylation, and Hedgehog signaling pathway studies.

Best Publications

  • Structure and function of adenosine receptors and their genes

    Bertil B. Fredholm;Giulia Arslan;Linda Halldner;Björn Kull

  • Signalling from adenosine receptors to mitogen-activated protein kinases

    Gunnar Schulte;Bertil B. Fredholm

  • Comparison of the potency of adenosine as an agonist at human adenosine receptors expressed in Chinese hamster ovary cells

    Bertil B Fredholm;Eva Irenius;Björn Kull;Gunnar Schulte

  • THE CONCISE GUIDE TO PHARMACOLOGY 2021/22: G protein-coupled receptors

    Stephen P.H. Alexander;Arthur Christopoulos;Anthony P. Davenport;Eamonn Kelly

  • Endocannabinoids regulate interneuron migration and morphogenesis by transactivating the TrkB receptor

    Paul Berghuis;Marton B. Dobszay;Xinyu Wang;Sabrina Spano

  • The Frizzled family of unconventional G-protein-coupled receptors.

    Gunnar Schulte;Vítězslav Bryja;Vítězslav Bryja

  • International Union of Basic and Clinical Pharmacology. LXXX. The Class Frizzled Receptors

    Gunnar Schulte

  • Human Adenosine A1, A2A, A2B, and A3 Receptors Expressed in Chinese Hamster Ovary Cells All Mediate the Phosphorylation of Extracellular-Regulated Kinase 1/2

    Gunnar Schulte;Bertil B. Fredholm

  • WNT Signaling in Activated Microglia Is Proinflammatory

    Carina Halleskog;Jan Mulder;Jenny Dahlström;Ken Mackie

  • Molecular reorganization of endocannabinoid signalling in Alzheimer’s disease

    Jan Mulder;Misha Zilberter;Susana J. Pasquaré;Susana J. Pasquaré;Alán Alpár

  • WNT/Frizzled signalling: receptor–ligand selectivity with focus on FZD-G protein signalling and its physiological relevance: IUPHAR Review 3

    J P Dijksterhuis;J Petersen;G Schulte

  • Wnt-5a induces Dishevelled phosphorylation and dopaminergic differentiation via a CK1-dependent mechanism.

    Vítězslav Bryja;Gunnar Schulte;Nina Rawal;Alexandra Grahn

  • Systematic Mapping of WNT-FZD Protein Interactions Reveals Functional Selectivity by Distinct WNT-FZD Pairs

    Jacomijn Petronella Dijksterhuis;Bolormaa Baljinnyam;Karen Stanger;Hakki Ogun Sercan

  • β-Arrestin is a necessary component of Wnt/β-catenin signaling in vitro and in vivo

    Vítězslav Bryja;Dietmar Gradl;Alexandra Schambony;Ernest Arenas

  • Modulation of glial cell functions by adenosine receptors.

    Elisabetta Daré;Gunnar Schulte;Olga Karovic;Christian Hammarberg

  • Purified Wnt-5a increases differentiation of midbrain dopaminergic cells and dishevelled phosphorylation.

    Gunnar Schulte;Vítězslav Bryja;Nina Rawal;Goncalo Castelo‐Branco

  • Sequential Activation and Inactivation of Dishevelled in the Wnt/β-Catenin Pathway by Casein Kinases

    Ondrej Bernatik;Ranjani Sri Ganji;Jacomijn P. Dijksterhuis;Peter Konik

  • Evidence for functional adenosine A3 receptors in microglia cells

    Christian Hammarberg;Gunnar Schulte;Bertil B. Fredholm

  • Mitogen-Activated Protein Kinases Promote WNT/β-Catenin Signaling via Phosphorylation of LRP6

    Igor Červenka;Joshua Wolf;Jan Mašek;Pavel Krejci

  • The Gs-coupled adenosine A2b receptor recruits divergent pathways to regulate ERK1/2 and p38☆☆

    Gunnar Schulte;Bertil B Fredholm

Frequent Co-Authors

Vítězslav Bryja
Vítězslav Bryja Masaryk University
Bertil B. Fredholm
Bertil B. Fredholm Karolinska Institute
Ernest Arenas
Ernest Arenas Karolinska Institute
Tibor Harkany
Tibor Harkany Medical University of Vienna
Jan Mulder
Jan Mulder Karolinska Institute
Thomas P. Sakmar
Thomas P. Sakmar Rockefeller University
Ken Mackie
Ken Mackie Indiana University
Lars Eriksson
Lars Eriksson Linköping University
Evi Kostenis
Evi Kostenis University of Bonn
Patrik Ernfors
Patrik Ernfors Karolinska Institute

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