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Daan J.A. Crommelin

Daan J.A. Crommelin

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Chemistry
Netherlands
2025

D-Index & Metrics

Chemistry

D-Index
91
Citations
24636
World Ranking
2008
National Ranking
47

Research.com Recognitions

  • 2025 - Research.com Chemistry in Netherlands Leader Award
  • 2022 - Research.com Chemistry in Netherlands Leader Award

Overview

Daan J.A. Crommelin is affiliated with Utrecht University in the Netherlands. Their research focuses primarily on medicine, with significant contributions in biochemistry, genetics, and molecular biology. Within these broader fields, their subfield expertise includes molecular biology, infectious diseases, immunology, radiology, nuclear medicine and imaging, and epidemiology.

Their main topics of research cover a variety of areas, notably protein purification and stability, RNA interference and gene delivery, SARS-CoV-2 and COVID-19 research, monoclonal and polyclonal antibodies research, immunotherapy and immune responses, animal virus infections, and hepatitis B virus studies.

Recent published papers associated with their work include:

  • "mRNA-lipid nanoparticle COVID-19 vaccines: Structure and stability" (2021) published in International Journal of Pharmaceutics
  • "Addressing the Cold Reality of mRNA Vaccine Stability" (2020) published in Journal of Pharmaceutical Sciences
  • "The Storage and In-Use Stability of mRNA Vaccines and Therapeutics: Not A Cold Case" (2022) published in Journal of Pharmaceutical Sciences
  • "Applying lessons learned from nanomedicines to understand rare hypersensitivity reactions to mRNA-based SARS-CoV-2 vaccines" (2022) published in Nature Nanotechnology
  • "Ongoing Challenges to Develop High Concentration Monoclonal Antibody-based Formulations for Subcutaneous Administration: Quo Vadis?" (2021) published in Journal of Pharmaceutical Sciences

Frequent co-authors collaborating with their research include Wim Jiskoot, David B. Volkin, Enrico Mastrobattista, Andrea Hawe, and Karin H. Hoogendoorn.

Their work appears across several publication venues with repeated contributions in the Journal of Pharmaceutical Sciences, International Journal of Pharmaceutics, Nature Nanotechnology, Pharmaceutical Research, and Acta Pharmaceutica Hungarica.

Best Publications

  • mRNA-lipid nanoparticle COVID-19 vaccines: Structure and stability.

    Linde Schoenmaker;Dominik Witzigmann;Jayesh A. Kulkarni;Rein Verbeke

  • Structure-immunogenicity relationships of therapeutic proteins.

    Suzanne Hermeling;Daan J. A. Crommelin;Huub Schellekens;Wim Jiskoot

  • Identification of Formaldehyde-induced Modifications in Proteins REACTIONS WITH MODEL PEPTIDES

    Bernard Metz;Gideon F.A. Kersten;Peter Hoogerhout;Humphrey F. Brugghe

  • Overlooking subvisible particles in therapeutic protein products: Gaps that may compromise product quality

    John F. Carpenter;Theodore W. Randolph;Wim Jiskoot;Daan J.A. Crommelin

  • Chemical stability of liposomes: implications for their physical stability

    Mustafa Grit;Daan J.A. Crommelin

  • Effect of Size and Serum Proteins on Transfection Efficiency of Poly ((2-dimethylamino)ethyl Methacrylate)-Plasmid Nanoparticles

    Jong-Yuh Cherng;Petra van de Wetering;Herre Talsma;Daan J. A. Crommelin

  • Artificial viruses: a nanotechnological approach to gene delivery

    Enrico Mastrobattista;Marieke A. E. M. van der Aa;Wim E. Hennink;Daan J. A. Crommelin

  • Liposomes: quo vadis?

    Gert Storm;Daan J.A Crommelin

  • Lymphatic uptake and biodistribution of liposomes after subcutaneous injection. II. Influence of liposomal size, lipid compostion and lipid dose.

    C. Oussoren;J. Zuidema;D.J.A. Crommelin;G. Storm

  • Addressing the Cold Reality of mRNA Vaccine Stability.

    Daan J.A. Crommelin;Thomas J. Anchordoquy;David B. Volkin;Wim Jiskoot

  • 2-(dimethylamino)ethyl methacrylate based (co)polymers as gene transfer agents

    P van de Wetering;J.-Y Cherng;H Talsma;D.J.A Crommelin

  • Liposomal and lipid formulations of amphotericin B : clinical pharmacokinetics

    Robert Janknegt;Siem de Marie;Irma A. J. M. Bakker-Woudenberg;Daan J. A. Crommelin

  • Endosomal Escape of Polymeric Gene Delivery Complexes Is Not Always Enhanced by Polymers Buffering at Low pH

    Arjen M Funhoff;Cornelus F van Nostrum;Gerben A Koning;Nancy M E Schuurmans-Nieuwenbroek

  • The role of liposomes in clinical nanomedicine development. What now? Now what?

    Daan J.A. Crommelin;Peter van Hoogevest;Gert Storm

  • N-Trimethyl chitosan (TMC) nanoparticles loaded with influenza subunit antigen for intranasal vaccination: Biological properties and immunogenicity in a mouse model

    Maryam Amidi;Stefan G. Romeijn;J. Coos Verhoef;Hans E. Junginger

  • Fourier Transform Infrared Spectrometric Analysis of Protein Conformation: Effect of Sampling Method and Stress Factors

    Marco van de Weert;Parvez I. Haris;Wim E. Hennink;Daan J.A. Crommelin

  • Protein instability and immunogenicity: Roadblocks to clinical application of injectable protein delivery systems for sustained release

    Wim Jiskoot;Theodore W. Randolph;David B. Volkin;C. Russell Middaugh

  • Shifting paradigms: biopharmaceuticals versus low molecular weight drugs

    Daan J.A. Crommelin;Gert Storm;Ruud Verrijk;Leo de Leede

  • Cellular uptake of cationic polymer-DNA complexes via caveolae plays a pivotal role in gene transfection in COS-7 cells.

    M. A. E. M. van der Aa;U. S. Huth;S. Y. Häfele;R. Schubert

  • The effect of a water/organic solvent interface on the structural stability of lysozyme

    Marco van de Weert;Julia Hoechstetter;Wim E Hennink;Daan J.A Crommelin

  • Potential inaccurate quantitation and sizing of protein aggregates by size exclusion chromatography: Essential need to use orthogonal methods to assure the quality of therapeutic protein products

    John F. Carpenter;Theodore W. Randolph;Wim Jiskoot;Daan J.A. Crommelin

  • Antibody response to aggregated human interferon alpha2b in wild-type and transgenic immune tolerant mice depends on type and level of aggregation.

    Suzanne Hermeling;Huub Schellekens;Coen Maas;Martijn F.B.G. Gebbink

  • Adhesion molecules: a new target for immunoliposome‐mediated drug delivery

    P.G.M. Bloemen;P.A.J. Henricks;L. van Bloois;M.C. van den Tweel

Frequent Co-Authors

Wim E. Hennink
Wim E. Hennink Utrecht University
Wim Jiskoot
Wim Jiskoot Leiden University
Gert Storm
Gert Storm Utrecht University
Gideon F.A. Kersten
Gideon F.A. Kersten Leiden University
Wijnand Eling
Wijnand Eling Radboud University Medical Center
Huub Schellekens
Huub Schellekens Utrecht University
Cornelus F. van Nostrum
Cornelus F. van Nostrum Utrecht University
James N. Herron
James N. Herron University of Utah
Geert-Jan Witkamp
Geert-Jan Witkamp King Abdullah University of Science and Technology
Hidde J. Haisma
Hidde J. Haisma University of Groningen

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