World's Best Scientists 2026 revealed!

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Immunology

D-Index
97
Citations
26531
World Ranking
836
National Ranking
470

Medicine

D-Index
97
Citations
26714
World Ranking
9436
National Ranking
4868

Research.com Recognitions

  • 2016 - Fellow of the American Association for the Advancement of Science (AAAS)
  • 2013 - Fellow, National Academy of Inventors

Overview

David E. Briles is affiliated with the University of Alabama at Birmingham in the United States. Their research primarily focuses on medicine, with a significant emphasis on immunology and microbiology. The main subfields of study include epidemiology, microbiology, public health, environmental and occupational health, immunology, and molecular biology.

Their work extensively covers topics related to pneumonia and respiratory infections, bacterial infections and vaccines, respiratory viral infections research, streptococcal infections and treatments, influenza virus research studies, glycosylation and glycoproteins research, and Pneumocystis jirovecii pneumonia detection and treatment.

David E. Briles has contributed to a number of scientific papers, including the following recent publications:

  • A nanogel-based trivalent PspA nasal vaccine protects macaques from intratracheal challenge with pneumococci, 2021, Vaccine
  • Streptococcus pneumoniae binds to host GAPDH on dying lung epithelial cells worsening secondary infection following influenza, 2021, Cell Reports
  • Streptococcus pneumoniae Binds to Host Lactate Dehydrogenase via PspA and PspC To Enhance Virulence, 2021, mBio
  • Characterization and Specification of a Trivalent Protein-Based Pneumococcal Vaccine Formulation Using an Adjuvant-Free Nanogel Nasal Delivery System, 2021, Molecular Pharmaceutics
  • A Jack of All Trades: The Role of Pneumococcal Surface Protein A in the Pathogenesis of Streptococcus pneumoniae, 2022, Frontiers in Cellular and Infection Microbiology

Frequent co-authors in their research include:

  • Carlos J. Orihuela (5 publications)
  • Yoshikazu Yuki (3 publications)
  • Shin-ichi Sawada (3 publications)
  • Reshmi Mukerji (3 publications)
  • Kazunari Akiyoshi (3 publications)

The scientist has published notably in journals such as:

  • mBio
  • The Pediatric Infectious Disease Journal
  • bioRxiv (Cold Spring Harbor Laboratory)
  • UNC Libraries
  • Vaccine

David E. Briles has been recognized with several awards, including being named a Fellow of the American Association for the Advancement of Science (AAAS) in 2016 and a Fellow of the National Academy of Inventors in 2013.

Best Publications

  • ANTIPHOSPHOCHOLINE ANTIBODIES FOUND IN NORMAL MOUSE SERUM ARE PROTECTIVE AGAINST INTRAVENOUS INFECTION WITH TYPE 3 STREPTOCOCCUS PNEUMONIAE

    David E. Briles;Moon Nahm;Kenneth Schroer;Joseph Davie

  • Subclass restriction of murine anti-carbohydrate antibodies.

    R M Perlmutter;D Hansburg;D E Briles;R A Nicolotti

  • Diversity of PspA: Mosaic Genes and Evidence for Past Recombination in Streptococcus pneumoniae

    Susan K. Hollingshead;Robert Becker;David E. Briles

  • Reduced virulence of a defined pneumolysin-negative mutant of Streptococcus pneumoniae.

    A M Berry;J Yother;D E Briles;D Hansman

  • Pneumococcal surface protein A inhibits complement activation by Streptococcus pneumoniae

    Anh-Hue T. Tu;Robert L. Fulgham;Mark A. McCrory;David E. Briles

  • Intranasal immunization of mice with a mixture of the pneumococcal proteins PsaA and PspA is highly protective against nasopharyngeal carriage of Streptococcus pneumoniae.

    David E. Briles;Eddie Ades;James C. Paton;Jacquelyn S. Sampson

  • Anti-phosphorylcholine antibodies of the T15 idiotype are optimally protective against Streptococcus pneumoniae.

    D E Briles;C Forman;S Hudak;J L Claflin

  • Immunization of Humans with Recombinant Pneumococcal Surface Protein A (rPspA) Elicits Antibodies That Passively Protect Mice from Fatal Infection with Streptococcus pneumoniae Bearing Heterologous PspA

    David E. Briles;Susan K. Hollingshead;Janice King;Amy Swift

  • Basophils enhance immunological memory responses.

    Andrea Denzel;Ulrich A Maus;Manuel Rodriguez Gomez;Cordula Moll;Cordula Moll

  • Pneumococcal surface protein A (PspA) is serologically highly variable and is expressed by all clinically important capsular serotypes of Streptococcus pneumoniae

    M. J. Crain;W. D. Waltman;J. S. Turner;J. Yother

  • Strong association between capsular type and virulence for mice among human isolates of Streptococcus pneumoniae.

    D E Briles;M J Crain;B M Gray;C Forman

  • The pspC gene of Streptococcus pneumoniae encodes a polymorphic protein, PspC, which elicits cross-reactive antibodies to PspA and provides immunity to pneumococcal bacteremia.

    Alexis Brooks-Walter;David E. Briles;Susan K. Hollingshead

  • PspA, a surface protein of Streptococcus pneumoniae, is capable of eliciting protection against pneumococci of more than one capsular type.

    L S McDaniel;J S Sheffield;P Delucchi;D E Briles

  • Intranasal Immunization of Mice with PspA (Pneumococcal Surface Protein A) Can Prevent Intranasal Carriage, Pulmonary Infection, and Sepsis with Streptococcus pneumoniae

    Hong-Yin Wu;Moon H. Nahm;Y. Guo;Michael W. Russell

  • PspA Protects Streptococcus pneumoniae from Killing by Apolactoferrin, and Antibody to PspA Enhances Killing of Pneumococci by Apolactoferrin

    Mirza Shaper;Susan K. Hollingshead;William H. Benjamin;David E. Briles

  • HUMAN C-REACTIVE PROTEIN IS PROTECTIVE AGAINST FATAL STREPTOCOCCUS PNEUMONIAE INFECTION IN TRANSGENIC MICE

    A J Szalai;D E Briles;J E Volanakis

  • Immunizations with Pneumococcal Surface Protein A and Pneumolysin Are Protective against Pneumonia in a Murine Model of Pulmonary Infection with Streptococcus pneumoniae

    David E. Briles;Susan K. Hollingshead;James C. Paton;Edwin W. Ades

  • Structural properties and evolutionary relationships of PspA, a surface protein of Streptococcus pneumoniae, as revealed by sequence analysis.

    J Yother;D E Briles

  • Development of a Vaccine against Invasive Pneumococcal Disease Based on Combinations of Virulence Proteins of Streptococcus pneumoniae

    Abiodun D. Ogunniyi;Marcin Grabowicz;David E. Briles;Jan Cook

  • Use of insertional inactivation to facilitate studies of biological properties of pneumococcal surface protein A (PspA).

    L S McDaniel;J Yother;M Vijayakumar;L McGarry

Frequent Co-Authors

Susan K. Hollingshead
Susan K. Hollingshead University of Alabama at Birmingham
Larry S. McDaniel
Larry S. McDaniel University of Mississippi Medical Center
Janet Yother
Janet Yother University of Alabama at Birmingham
William H. Benjamin
William H. Benjamin University of Alabama at Birmingham
James C. Paton
James C. Paton University of Adelaide
Moon H. Nahm
Moon H. Nahm University of Alabama at Birmingham
Joseph M. Davie
Joseph M. Davie Pfizer (Germany)
Alexander J. Szalai
Alexander J. Szalai University of Alabama at Birmingham
John F. Kearney
John F. Kearney University of Alabama at Birmingham
Hiroshi Kiyono
Hiroshi Kiyono University of Tokyo

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