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Microbiology

D-Index
73
Citations
20057
World Ranking
1650
National Ranking
139

Overview

David J. Rowlands is affiliated with the University of Leeds in the United Kingdom and has contributed extensively to the field of Medicine, with a focus on Pulmonary and Respiratory Medicine, Epidemiology, and Cardiology and Cardiovascular Medicine. Their research also spans Molecular Biology and Infectious Diseases.

The main topics of their work include:

  • Viral Infections and Immunology Research
  • Animal Disease Management and Epidemiology
  • Cystic Fibrosis Research Advances
  • Viral gastroenteritis research and epidemiology
  • Hepatitis B Virus Studies
  • Identity, Memory, and Therapy
  • Ubiquitin and proteasome pathways

David J. Rowlands has authored several recent papers across different areas within medical research. Notable publications include:

  • "Deubiquitinase-targeting chimeras for targeted protein stabilization" (2022) published in Nature Chemical Biology
  • "Efficacy and Safety of the CFTR Potentiator Icenticaftor (QBW251) in COPD: Results from a Phase 2 Randomized Trial" (2020) published in International Journal of COPD
  • "Cystic fibrosis transmembrane conductance regulator in COPD: a role in respiratory epithelium and beyond" (2022) published in European Respiratory Journal
  • "Discovery of Icenticaftor (QBW251), a Cystic Fibrosis Transmembrane Conductance Regulator Potentiator with Clinical Efficacy in Cystic Fibrosis and Chronic Obstructive Pulmonary Disease" (2021) published in Journal of Medicinal Chemistry
  • "Safety and efficacy of the cystic fibrosis transmembrane conductance regulator potentiator icenticaftor (QBW251)" (2020) published in Journal of Cystic Fibrosis

Frequent co-authors collaborating with David J. Rowlands include:

  • Nicola J. Stonehouse
  • G. Darby
  • Gerald Gough
  • E. Littler
  • Margaret Tisdale

The scientific output of David J. Rowlands is regularly published in prominent venues such as:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Journal of Medicinal Chemistry
  • PLoS Pathogens
  • ChemMedChem
  • Journal of General Virology

Best Publications

  • Protection against foot-and-mouth disease by immunization with a chemically synthesized peptide predicted from the viral nucleotide sequence

    James L. Bittle;Richard A. Houghten;Hannah Alexander;Thomas M. Shinnick

  • The three-dimensional structure of foot-and-mouth disease virus at 2.9 A resolution.

    Ravindra Acharya;Elizabeth Fry;David Stuart;Graham Fox

  • The p7 protein of hepatitis C virus forms an ion channel that is blocked by the antiviral drug, Amantadine.

    Stephen D.C. Griffin;Lucy P. Beales;Dean S. Clarke;Oliver Worsfold

  • Myristylation of picornavirus capsid protein VP4 and its structural significance.

    M. Chow;J. F. E. Newman;D. Filman;J. M. Hogle

  • The cell attachment site on foot-and-mouth disease virus includes the amino acid sequence RGD (arginine-glycine-aspartic acid)

    Graham Fox;Nigel R. Parry;Paul V. Barnett;Brian McGinn

  • Improved immunogenicity of a peptide epitope after fusion to hepatitis B core protein.

    B. E. Clarke;S. E. Newton;A. R. Carroll;M. J. Francis

  • Structure of a major immunogenic site on foot-and-mouth disease virus.

    Derek Logan;Derek Logan;Robin Abu-Ghazaleh;Wendy Blakemore;Stephen Curry

  • A sensor-adaptor mechanism for enterovirus uncoating from structures of EV71

    Xiangxi Wang;Wei Peng;Jingshan Ren;Zhongyu Hu

  • Mouse models of rhinovirus-induced disease and exacerbation of allergic airway inflammation

    Nathan W Bartlett;Ross P Walton;Michael R Edwards;Juliya Aniscenko

  • Structural Requirements for Initiation of Translation by Internal Ribosome Entry within Genome-Length Hepatitis C Virus RNA

    Masao Honda;Li Hua Ping;Rene C.A. Rijnbrand;Elizabeth Amphlett

  • Non-responsiveness to a foot-and-mouth disease virus peptide overcome by addition of foreign helper T-cell determinants.

    Michael J. Francis;Gillian Z. Hastings;Andrew D. Syred;Brian McGinn

  • Intracellular Proton Conductance of the Hepatitis C Virus p7 Protein and Its Contribution to Infectious Virus Production

    Ann L. Wozniak;Stephen Griffin;Stephen Griffin;David Rowlands;Mark Harris

  • Structural and serological evidence for a novel mechanism of antigenic variation in foot-and-mouth disease virus

    Nigel Parry;Graham Fox;David Rowlands;Fred Brown

  • Chemical basis of antigenic variation in foot-and-mouth disease virus.

    D. J. Rowlands;B. E. Clarke;A. R. Carroll;F. Brown

  • A conserved basic loop in hepatitis C virus p7 protein is required for amantadine-sensitive ion channel activity in mammalian cells but is dispensable for localization to mitochondria.

    Stephen D. C. Griffin;Ruth Harvey;Dean S. Clarke;Wendy S. Barclay

  • Substrate complexes of hepatitis C virus RNA polymerase (HC-J4): structural evidence for nucleotide import and de-novo initiation.

    Damien O'Farrell;Rachel Trowbridge;David Rowlands;Joachim Jäger

  • Internal initiation of translation of hepatitis C virus RNA: the ribosome entry site is at the authentic initiation codon.

    J E Reynolds;A Kaminski;A R Carroll;B E Clarke

  • Hepatitis A virus and the origins of picornaviruses

    Xiangxi Wang;Jingshan Ren;Qiang Gao;Qiang Gao;Zhongyu Hu

  • Evidence for the formation of a heptameric ion channel complex by the hepatitis C virus p7 protein in vitro.

    Dean Clarke;Stephen Griffin;Lucy Beales;Corine St. Gelais

  • The complete nucleotide sequence of the RNA coding for the primary translation product of foot and mouth disease virus.

    A.R. Carroll;D.J. Rowlands;B.E. Clarke

Frequent Co-Authors

Fred Brown
Fred Brown United States Department of Agriculture
David I. Stuart
David I. Stuart University of Oxford
Mark Harris
Mark Harris University of Leeds
Elizabeth E. Fry
Elizabeth E. Fry University of Oxford
Zihe Rao
Zihe Rao Tsinghua University
John C. Boothroyd
John C. Boothroyd Stanford University
Robert J. C. Gilbert
Robert J. C. Gilbert University of Oxford
Jianwei Wang
Jianwei Wang Peking Union Medical College Hospital
Jingshan Ren
Jingshan Ren University of Oxford
Jahar Bhattacharya
Jahar Bhattacharya Columbia University

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