His primary scientific interests are in Biochemistry, Nitric oxide, Nitric oxide synthase, Tetrahydrobiopterin and Soluble guanylyl cyclase. His work in Biochemistry tackles topics such as Molecular biology which are related to areas like Arginine. His research in Nitric oxide intersects with topics in Peroxynitrite, Superoxide and Intracellular.
His biological study spans a wide range of topics, including IC50 and Enzyme inhibitor. His Tetrahydrobiopterin research includes elements of Pteridine and Stereochemistry. The concepts of his Soluble guanylyl cyclase study are interwoven with issues in Superoxide dismutase, Glutamate receptor, Cytosol, Second messenger system and Pharmacology.
Kurt Schmidt mainly investigates Biochemistry, Nitric oxide, Nitric oxide synthase, Enzyme and Tetrahydrobiopterin. His work is connected to Heme, Aldehyde dehydrogenase, Soluble guanylyl cyclase, Superoxide dismutase and Arginine, as a part of Biochemistry. His Heme research incorporates elements of Protein subunit, Binding site and Tetrahydrobiopterin binding.
His research integrates issues of Peroxynitrite, Superoxide and Glutathione in his study of Nitric oxide. Kurt Schmidt works mostly in the field of Nitric oxide synthase, limiting it down to topics relating to Enzyme inhibitor and, in certain cases, Nitroarginine, as a part of the same area of interest. His work carried out in the field of Tetrahydrobiopterin brings together such families of science as Pteridine, Stereochemistry and Pterin.
Kurt Schmidt mainly investigates Biochemistry, Nitric oxide, Enos, Internal medicine and Pharmacology. The Tetrahydrobiopterin, Enzyme, Activator and Enos phosphorylation research he does as part of his general Biochemistry study is frequently linked to other disciplines of science, such as Lysophosphatidylcholine, therefore creating a link between diverse domains of science. His Nitric oxide research focuses on Nitric oxide synthase in particular.
Kurt Schmidt has included themes like Biophysics, Receptor, Cholesterol, Dihydrofolate reductase and Mitochondrion in his Enos study. His work in Internal medicine addresses subjects such as Endocrinology, which are connected to disciplines such as Urocortin, Intracellular and Protein kinase B. His studies in Pharmacology integrate themes in fields like ALDH2 and Blood vessel.
His primary scientific interests are in Nitric oxide, Enos, Biochemistry, Nitric oxide synthase and Glutathione. He integrates Nitric oxide with Plasminogen activator inhibitor-1 in his study. He interconnects Urocortin, PI3K/AKT/mTOR pathway, Signal transduction, Phosphorylation and Forskolin in the investigation of issues within Enos.
His Nitric Oxide Synthase Type III, Biopterin, Dihydrobiopterin, Dihydrofolate reductase and Superoxide investigations are all subjects of Biochemistry research. His research on Nitric oxide synthase concerns the broader Enzyme. His Glutathione study incorporates themes from Superoxide dismutase, Reaction rate, Reaction rate constant, Nucleophile and Nitrosation.
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Potent and selective inhibition of nitric oxide-sensitive guanylyl cyclase by 1H-[1,2,4]oxadiazolo[4,3-a]quinoxalin-1-one.
J Garthwaite;E Southam;C L Boulton;E B Nielsen.
Molecular Pharmacology (1995)
Inhibition of nitric oxide synthesis by methylene blue
Bernd Mayer;Friedrich Brunner;Kurt Schmidt.
Biochemical Pharmacology (1993)
Characterization of 1H-[1,2,4]oxadiazolo[4,3-a]quinoxalin-1-one as a heme-site inhibitor of nitric oxide-sensitive guanylyl cyclase.
Astrid Schrammel;Soenke Behrends;Kurt Schmidt;Doris Koesling.
Molecular Pharmacology (1996)
Metabolic Fate of Peroxynitrite in Aqueous Solution REACTION WITH NITRIC OXIDE AND pH-DEPENDENT DECOMPOSITION TO NITRITE AND OXYGEN IN A 2:1 STOICHIOMETRY
Silvia Pfeiffer;Antonius C.F. Gorren;Kurt Schmidt;Ernst R. Werner.
Journal of Biological Chemistry (1997)
Biosynthesis of endothelium-derived relaxing factor: a cytosolic enzyme in porcine aortic endothelial cells Ca2+-dependently converts L-arginine into an activator of soluble guanylyl cyclase.
Bernd Mayer;Kurt Schmidt;Peter Humbert;Eycke Böhme.
Biochemical and Biophysical Research Communications (1989)
Structural analysis of porcine brain nitric oxide synthase reveals a role for tetrahydrobiopterin and L-arginine in the formation of an SDS-resistant dimer.
P Klatt;K Schmidt;D Lehner;O Glatter.
The EMBO Journal (1995)
Multiple catalytic functions of brain nitric oxide synthase. Biochemical characterization, cofactor-requirement, and the role of N omega-hydroxy-L-arginine as an intermediate.
P Klatt;K Schmidt;G Uray;B Mayer.
Journal of Biological Chemistry (1993)
Pteridine biosynthesis in human endothelial cells. Impact on nitric oxide-mediated formation of cyclic GMP
G Werner-Felmayer;E R Werner;D Fuchs;A Hausen.
Journal of Biological Chemistry (1993)
The pteridine binding site of brain nitric oxide synthase. Tetrahydrobiopterin binding kinetics, specificity, and allosteric interaction with the substrate domain.
P Klatt;M Schmid;E Leopold;K Schmidt.
Journal of Biological Chemistry (1994)
A New Pathway of Nitric Oxide/Cyclic GMP Signaling InvolvingS-Nitrosoglutathione
Bernd Mayer;Silvia Pfeiffer;Astrid Schrammel;Doris Koesling.
Journal of Biological Chemistry (1998)
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