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Chemistry

D-Index
66
Citations
11556
World Ranking
7506
National Ranking
40

Overview

Karl Gruber is affiliated with the University of Graz in Austria. Their scholarly work spans across multiple domains within biochemistry, genetics, molecular biology, and medicine, with a total of 55 publications in Biochemistry, Genetics and Molecular Biology and 44 publications in Medicine. The scientist has contributed extensively to subfields including Molecular Biology, Infectious Diseases, Computational Theory and Mathematics, Organic Chemistry, and Oncology.

The research topics Karl Gruber focuses on include Computational Drug Discovery Methods, SARS-CoV-2 and COVID-19 Research, Enzyme Catalysis and Immobilization, RNA and protein synthesis mechanisms, Genomics and Phylogenetic Studies, Peptidase Inhibition and Analysis, and Protein Structure and Dynamics.

Some of the recent publications by Karl Gruber are:

  • Serine 477 plays a crucial role in the interaction of the SARS-CoV-2 spike protein with the human receptor ACE2 (2021, Scientific Reports)
  • Rediscovering Asia's forgotten crops to fight chronic and hidden hunger (2021, Nature Plants)
  • Dipeptidyl peptidase 3 modulates the renin-angiotensin system in mice (2020, Journal of Biological Chemistry)
  • Unravelling the respiratory health path across the lifespan for survivors of preterm birth (2023, The Lancet Respiratory Medicine)
  • Small-Molecule Inhibitors Targeting Lipolysis in Human Adipocytes (2022, Journal of the American Chemical Society)

Karl Gruber frequently publishes in journals such as The Lancet Oncology, ACS Catalysis, Scientific Reports, Research Square, and the Journal of Biological Chemistry. The number of their publications varies by venue, with ten contributions to The Lancet Oncology and six to ACS Catalysis among others.

Collaborations have been an important part of Gruber's research output. Frequent co-authors include Georg Steinkellner, Christian Gruber, Amit Singh, A. Krassnigg, and Tea Pavkov-Keller, with co-authorship counts ranging from 11 to 19 publications each.

Best Publications

  • Enzymatic surface hydrolysis of PET : effect of structural diversity on kinetic properties of cutinases from thermobifida

    Enrique Herrero Acero;Doris Ribitsch;Georg Steinkellner;Karl Gruber

  • Vitamin B12-derivatives—enzyme cofactors and ligands of proteins and nucleic acids

    Karl Gruber;Barbara Puffer;Bernhard Kräutler

  • Glutamate mutase from Clostridium cochlearium: the structure of a coenzyme B12-dependent enzyme provides new mechanistic insights.

    R Reitzer;K Gruber;G Jogl;UG Wagner

  • Asymmetric Bioreduction of CC Bonds using Enoate Reductases OPR1, OPR3 and YqjM: Enzyme‐Based Stereocontrol

    Melanie Hall;Clemens Stueckler;Heidemarie Ehammer;Eva Maria Pointner

  • Thermophilic xylanase from Thermomyces lanuginosus: high-resolution X-ray structure and modeling studies.

    Karl Gruber;Gerd Klintschar;Marianne Hayn;Anton Schlacher

  • A New Esterase from Thermobifida halotolerans Hydrolyses Polyethylene Terephthalate (PET) and Polylactic Acid (PLA)

    Doris Ribitsch;Enrique Herrero Acero;Katrin Greimel;Anita Dellacher

  • A Biocatalytic Henry Reaction—The Hydroxynitrile Lyase from Hevea brasiliensis Also Catalyzes Nitroaldol Reactions

    Thomas Purkarthofer;Karl Gruber;Mandana Gruber-Khadjawi;Kerstin Waich

  • Fusion of binding domains to Thermobifida cellulosilytica cutinase to tune sorption characteristics and enhancing PET hydrolysis.

    Doris Ribitsch;Antonio Orcal Yebra;Sabine Zitzenbacher;Jing Wu

  • Surface engineering of a cutinase from Thermobifida cellulosilytica for improved polyester hydrolysis.

    Enrique Herrero Acero;Doris Ribitsch;Anita Dellacher;Sabine Zitzenbacher

  • The Cofactor of Tetrachloroethene Reductive Dehalogenase of Dehalospirillum multivorans Is Norpseudo‐B12, a New Type of a Natural Corrinoid

    Bernhard Kräutler;Wolfgang Fieber;Sigrid Ostermann;Mario Fasching

  • Direct Evidence for the Conformational Deformation of the Corrin Ring by the Nucleotide Base in Vitamin B12: Synthesis and Solution Spectroscopic and Crystal Structure Analysis of Co.beta.-Cyanoimidazolylcobamide

    Bernhard Kraeutler;Robert Konrat;Erhard Stupperich;Gerald Faerber

  • A concerted mechanism for berberine bridge enzyme.

    Andreas Winkler;Andrzej Lyskowski;Sabrina Riedl;Sabrina Riedl;Martin Puhl

  • Radical Shuttling in a Protein: Ribose Pseudorotation Controls Alkyl‐Radical Transfer in the Coenzyme B12 Dependent Enzyme Glutamate Mutase

    Karl Gruber;Riikka Reitzer;Christoph Kratky

  • Accurate Structural Data Demystify B-12 - High-Resolution Solid-State Structure of Aquocobalamin Perchlorate and Structure-Analysis of the Aquocobalamin Ion in Solution

    Christoph Kratky;Gerald Farber;Karl Gruber;Keith Wilson

  • Comprehensive Step‐by‐Step Engineering of an (R)‐Hydroxynitrile Lyase for Large‐Scale Asymmetric Synthesis

    Anton Glieder;Roland Weis;Wolfgang Skranc;Peter Poechlauer

  • A Topochemically Controlled, Regiospecific Fullerene Bisfunctionalization

    Bernhard Kräutler;Thomas Müller;Joseph Maynollo;Karl Gruber

  • The hydroxynitrile lyase from almond: a lyase that looks like an oxidoreductase.

    Ingrid Dreveny;Karl Gruber;Anton Glieder;Andrew Thompson

  • Determination of β-2 Microglobulin Levels in Plasma Using a High-Throughput Mass Spectrometric Immunoassay System

    Eric E. Niederkofler;Kemmons A. Tubbs;Karl Gruber;Dobrin Nedelkov

  • Improving enzymatic polyurethane hydrolysis by tuning enzyme sorption

    Caroline Gamerith;Enrique Herrero Acero;Alessandro Pellis;Andreas Ortner

  • Synthesis, crystal structure, and characterization of three novel compounds of the quinolone family member (norfloxacin)

    Iztok Turel;Karl Gruber;Ivan Leban;Nataša Bukovec

  • High-throughput protein characterization using mass spectrometric immunoassay.

    Urban A. Kiernan;Kemmons A. Tubbs;Karl Gruber;Dobrin Nedelkov

  • Serine 477 plays a crucial role in the interaction of the SARS-CoV-2 spike protein with the human receptor ACE2.

    Amit Singh;Georg Steinkellner;Katharina Köchl;Karl Gruber

Frequent Co-Authors

Peter Macheroux
Peter Macheroux Graz University of Technology
Bernhard Kräutler
Bernhard Kräutler University of Innsbruck
Wolfgang Kroutil
Wolfgang Kroutil University of Graz
Kurt Faber
Kurt Faber University of Graz
Rolf Breinbauer
Rolf Breinbauer Graz University of Technology
Georg M. Guebitz
Georg M. Guebitz BOKU University
Klaus Zangger
Klaus Zangger University of Graz
Bernd Nidetzky
Bernd Nidetzky Graz University of Technology
Herfried Griengl
Herfried Griengl Graz University of Technology
Sirano Dhe-Paganon
Sirano Dhe-Paganon Harvard University

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