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Biology and Biochemistry
Germany
2026

D-Index & Metrics

Biology and Biochemistry

D-Index
98
Citations
39677
World Ranking
1645
National Ranking
108

Medicine

D-Index
98
Citations
40285
World Ranking
8853
National Ranking
494

Research.com Recognitions

  • 2026 - Research.com Biology and Biochemistry in Germany Leader Award

Overview

Thomas Klopstock is affiliated with Ludwig-Maximilians-Universität München in Germany. Their research primarily focuses on biochemistry, genetics, and molecular biology, with a significant interdisciplinary presence in medicine. The scientist's work spans several subfields including molecular biology, neurology, cellular and molecular neuroscience, ophthalmology, and clinical biochemistry.

Their research covers various topics with an emphasis on mitochondrial function and pathology, genetic neurodegenerative diseases, metabolism and genetic disorders, neurological diseases and metabolism, retinal development and disorders, drug-induced ocular toxicity, and ATP synthase and ATPases research.

Thomas Klopstock has contributed extensively to scientific literature, with notable publications in several prominent journals. Recent papers include:

  • Bilateral visual improvement with unilateral gene therapy injection for Leber hereditary optic neuropathy, 2020, Science Translational Medicine
  • Mitochondrial disease in adults: recent advances and future promise, 2021, The Lancet Neurology
  • Clinical implementation of RNA sequencing for Mendelian disease diagnostics, 2022, Genome Medicine
  • Efficacy and Safety of Intravitreal Gene Therapy for Leber Hereditary Optic Neuropathy Treated within 6 Months of Disease Onset, 2021, Ophthalmology
  • Impaired complex I repair causes recessive Leber's hereditary optic neuropathy, 2021, Journal of Clinical Investigation

The scientist has collaborated frequently with several researchers including Valério Carelli, Patrick Yu-Wai-Man, Lüdger Schöls, Holger Prokisch, and Claudia B. Catarino. These collaborations have supported interdisciplinary approaches in their fields of study.

Thomas Klopstock's publications are distributed among several scientific venues, with a concentration in Acta Ophthalmologica, bioRxiv (Cold Spring Harbor Laboratory), Movement Disorders, Orphanet Journal of Rare Diseases, and Neurology.

Best Publications

  • Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)

    Daniel J. Klionsky;Amal Kamal Abdel-Aziz;Sara Abdelfatah;Mahmoud Abdellatif

  • High levels of mitochondrial DNA deletions in substantia nigra neurons in aging and Parkinson disease.

    Andreas Bender;Kim J Krishnan;Christopher M Morris;Geoffrey A Taylor

  • Genome-wide, large-scale production of mutant mice by ENU mutagenesis

    M. H. Hrabe de Angelis;H. Flaswinkel;H. Fuchs;B. Rathkolb

  • A humanized version of Foxp2 affects cortico-basal ganglia circuits in mice

    Wolfgang Enard;Sabine Gehre;Kurt Hammerschmidt;Sabine M. Hölter

  • Aberrant methylation of tRNAs links cellular stress to neuro‐developmental disorders

    Sandra Blanco;Sabine Dietmann;Joana V Flores;Shobbir Hussain

  • A randomized placebo-controlled trial of idebenone in Leber’s hereditary optic neuropathy

    Thomas Klopstock;Patrick Yu-Wai-Man;Patrick Yu-Wai-Man;Konstantinos Dimitriadis;Jacinthe Rouleau

  • Post-stroke inhibition of induced NADPH oxidase type 4 prevents oxidative stress and neurodegeneration.

    Christoph Kleinschnitz;Henrike Grund;Kirstin Wingler;Melanie Elise Armitage

  • Phenotypic spectrum associated with mutations of the mitochondrial polymerase γ gene

    R Horvath;G Hudson;G Ferrari;N Futterer

  • Rapamycin extends murine lifespan but has limited effects on aging

    Frauke Neff;Diana Flores-Dominguez;Devon P. Ryan;Marion Horsch

  • Targeted next generation sequencing as a diagnostic tool in epileptic disorders

    Johannes R. Lemke;Erik Riesch;Tim Scheurenbrand;Max Schubach

  • Gene-environment interactions in Leber hereditary optic neuropathy.

    Matthew Anthony Kirkman;Patrick Yu-Wai-Man;Patrick Yu-Wai-Man;Alex Korsten;Miriam Leonhardt

  • Neuron-glia communication via EphA4/ephrin-A3 modulates LTP through glial glutamate transport.

    Alessandro Filosa;Sonia Paixao;Silke D. Honsek;Maria A. Carmona

  • Hereditary spastic paraplegia: Clinicogenetic lessons from 608 patients.

    Rebecca Schüle;Sarah Wiethoff;Peter Martus;Kathrin N. Karle;Kathrin N. Karle

  • The Spastic Paraplegia Rating Scale (SPRS): A reliable and valid measure of disease severity

    R. Schüle;T. Holland-Letz;S. Klimpe;J. Kassubek

  • SDHAF1, encoding a LYR complex-II specific assembly factor, is mutated in SDH-defective infantile leukoencephalopathy.

    Daniele Ghezzi;Paola Goffrini;Graziella Uziel;Rita Horvath;Rita Horvath

  • Prevalence of sexual dimorphism in mammalian phenotypic traits

    Natasha A. Karp;Natasha A. Karp;Jeremy Mason;Arthur L. Beaudet;Yoav Benjamini

  • Absence of an Orphan Mitochondrial Protein, C19orf12, Causes a Distinct Clinical Subtype of Neurodegeneration with Brain Iron Accumulation

    Monika B. Hartig;Arcangela Iuso;Tobias Haack;Tomasz Kmiec

  • Loss-of-function mutations in MGME1 impair mtDNA replication and cause multisystemic mitochondrial disease

    Cornelia Kornblum;Thomas J Nicholls;Tobias B Haack;Susanne Schöler

  • Creatine supplementation in Parkinson disease: a placebo-controlled randomized pilot trial.

    A. Bender;W. Koch;M. Elstner;Y. Schombacher

  • Phenotypic spectrum associated with mutations of the mitochondrial polymerase γ gene. Commentary

    Salvatore Dimauro;Guido Davidzon;Michio Hirano;Rita Horvath

Frequent Co-Authors

Holger Prokisch
Holger Prokisch Technical University of Munich
Valerie Gailus-Durner
Valerie Gailus-Durner Helmholtz Zentrum München
Thomas Meitinger
Thomas Meitinger Technical University of Munich
Helmut Fuchs
Helmut Fuchs Helmholtz Zentrum München
Ludger Schöls
Ludger Schöls University of Tübingen
Wolfgang Wurst
Wolfgang Wurst German Center for Neurodegenerative Diseases
Eckhard Wolf
Eckhard Wolf Ludwig-Maximilians-Universität München
Martin Klingenspor
Martin Klingenspor Technical University of Munich
Martin Hrabé de Angelis
Martin Hrabé de Angelis Technical University of Munich
Rita Horvath
Rita Horvath University of Cambridge

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