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Brian D. Sykes

Brian D. Sykes

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Chemistry
Canada
2025

D-Index & Metrics

Chemistry

D-Index
100
Citations
50852
World Ranking
1247
National Ranking
27

Research.com Recognitions

  • 2025 - Research.com Chemistry in Canada Leader Award
  • 2022 - Research.com Chemistry in Canada Leader Award

Overview

Brian D. Sykes is affiliated with the University of Alberta in Canada, where their research encompasses a range of topics within medicine and biochemistry. Their work includes significant contributions in cardiology and cardiovascular medicine as well as molecular biology, particularly focused on the mechanisms of muscle function and related biochemical processes.

The scientist's recent publications cover various specialized fields and have appeared in multiple journals. Notable papers include:

  • Structural Basis of Tirasemtiv Activation of Fast Skeletal Muscle, 2021, Journal of Medicinal Chemistry
  • Optimizing fluorine labelling for 19F solid-state NMR in oriented biological systems, 2020, Journal of Biomolecular NMR
  • The Role of Electrostatics in the Mechanism of Cardiac Thin Filament Based Sensitizers, 2020, ACS Chemical Biology
  • Conversion of a Cardiac Muscle Modulator from an Inhibitor to an Activator, 2023, ACS Medicinal Chemistry Letters
  • Metabolomic study of disease progression in scrapie prion infected mice; validation of a novel method for brain metabolite extraction, 2020, Metabolomics

Their frequent coauthors include colleagues with expertise in related fields. Some coauthors with multiple collaborations are Fangze Cai, Thomas Kampourakis, Kieran T. Cockburn, Ian M. Robertson, and Brittney A. Klein.

The research has been published primarily in venues such as:

  • ACS Medicinal Chemistry Letters
  • Journal of Biomolecular NMR
  • ACS Chemical Biology
  • Biophysical Journal
  • bioRxiv (Cold Spring Harbor Laboratory)

Main fields of study for the scientist are centered around medicine, with 22 publications, and biochemistry, genetics, and molecular biology, with 12 publications. Subfields of particular focus include cardiology and cardiovascular medicine, molecular biology, spectroscopy, radiology and nuclear medicine, and biophysics.

The primary topics of their research work include:

  • Cardiomyopathy and Myosin Studies
  • Advanced NMR Techniques and Applications
  • Electron Spin Resonance Studies
  • Force Microscopy Techniques and Applications
  • RNA and protein synthesis mechanisms
  • Cardiovascular Function and Risk Factors
  • Pancreatic function and diabetes

Best Publications

  • HMDB: The human metabolome database

    David S. Wishart;Dan Tzur;Craig Knox;Roman Eisner

  • 1H, 13C and 15N chemical shift referencing in biomolecular NMR

    D S Wishart;C G Bigam;J Yao;F Abildgaard

  • The chemical shift index: A fast and simple method for the assignment of protein secondary structure through NMR spectroscopy

    D. S. Wishart;B. D. Sykes;F. M. Richards

  • The 13C chemical-shift index: a simple method for the identification of protein secondary structure using 13C chemical-shift data.

    David S. Wishart;Brian D. Sykes

  • Relationship between nuclear magnetic resonance chemical shift and protein secondary structure.

    D.S. Wishart;B.D. Sykes;F.M. Richards

  • 1H, 13C and 15N random coil NMR chemical shifts of the common amino acids. I. Investigations of nearest-neighbor effects.

    David S. Wishart;Colin G. Bigam;Arne Holm;Robert S. Hodges

  • Chemical shifts as a tool for structure determination.

    David S Wishart;Brian D Sykes

  • VADAR: a web server for quantitative evaluation of protein structure quality

    Leigh Willard;Anuj Ranjan;Haiyan Zhang;Hassan Monzavi

  • Solution structure and basis for functional activity of stromal cell-derived factor-1; dissociation of CXCR4 activation from binding and inhibition of HIV-1.

    Matthew P. Crump;Jiang Hong Gong;Pius Loetscher;Krishna Rajarathnam

  • Effect of trifluoroethanol on protein secondary structure: an NMR and CD study using a synthetic actin peptide.

    F. D. Sonnichsen;J. E. Van Eyk;R. S. Hodges;B. D. Sykes

  • Recommendations for the presentation of NMR structures of proteins and nucleic acids

    John L. Markley;Ad Bax;Yoji Arata;C. W. Hilbers

  • Recommendations for the presentation of NMR structures of proteins and nucleic acids. IUPAC-IUBMB-IUPAB Inter-Union Task Group on the Standardization of Data Bases of Protein and Nucleic Acid Structures Determined by NMR Spectroscopy.

    John L. Markley;Ad Bax;Yoji Arata;C. W. Hilbers

  • 1H, 13C and 15N random coil NMR chemical shifts of the common amino acids. I. Investigations of nearest-neighbor effects

    Unknown

  • β-Helix structure and ice-binding properties of a hyperactive antifreeze protein from an insect

    Steffen P. Graether;Steffen P. Graether;Michael J. Kuiper;Stéphane M. Gagné;Virginia K. Walker

  • Recommendations for the presentation of NMR structures of proteins and nucleic acids (IUPAC Recommendations 1998)

    John L. Markley;Ad Bax;Yoji Arata;C. W. Hilbers

  • Structure-activity relationships of chemokines.

    Ian Clark-Lewis;Key-Sun Kim;Krishnakumar Rajarathnam;Jiang-Hong Gong

  • Water Eliminated Fourier Transform NMR Spectroscopy

    Steven L. Patt;Brian D. Sykes

  • Neutrophil activation by monomeric interleukin-8

    Krishnakumar Rajarathnam;Brian D. Sykes;Cyril M. Kay;Beatrice Dewald

  • Binding of cardiac troponin-I147-163 induces a structural opening in human cardiac troponin-C.

    Monica X. Li;Leo Spyracopoulos;Brian D. Sykes

  • Measurement of 2H T1 and T1.rho. Relaxation Times in Uniformly 13C-Labeled and Fractionally 2H-Labeled Proteins in Solution

    D. R. Muhandiram;Toshio Yamazaki;Brian D. Sykes;Lewis E. Kay

  • Structures of the troponin C regulatory domains in the apo and calcium-saturated states.

    Stéphane M. Gagné;Sakae Tsuda;Monica X. Li;Lawrence B. Smillie

  • Structural and functional analysis of the Na+/H+ exchanger

    Emily R. Slepkov;Jan K. Rainey;Brian D. Sykes;Larry Fliegel

Frequent Co-Authors

Robert S. Hodges
Robert S. Hodges University of Colorado Denver
Cyril M. Kay
Cyril M. Kay University of Alberta
David S. Wishart
David S. Wishart University of Alberta
Frank D. Sönnichsen
Frank D. Sönnichsen Kiel University
Peter L. Davies
Peter L. Davies Queen's University
Larry Fliegel
Larry Fliegel University of Alberta
Robert O. Ryan
Robert O. Ryan University of Nevada Reno
Lawrence B. Smillie
Lawrence B. Smillie University of Alberta
Matthew P. Crump
Matthew P. Crump University of Bristol
Ian Clark-Lewis
Ian Clark-Lewis University of British Columbia

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