World's Best Scientists 2026 revealed!
Brian D. Sykes

Brian D. Sykes

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Chemistry
Canada
2025

D-Index & Metrics

Chemistry

D-Index
100
Citations
50852
World Ranking
1247
National Ranking
27

Brian D. Sykes publication distribution in Chemistry in 2026

The chart shows the distribution of publications by all Research.com ranked scientists in the field of Chemistry in 2026. The highlighted bar marks where Brian D. Sykes sits on this spectrum.

61–80 publications: 66 scientists 81–100 publications: 302 scientists 101–120 publications: 623 scientists 121–140 publications: 918 scientists 141–160 publications: 1,218 scientists 161–180 publications: 1,350 scientists 181–200 publications: 1,344 scientists 201–220 publications: 1,281 scientists 221–240 publications: 1,216 scientists 241–260 publications: 1,100 scientists 261–280 publications: 979 scientists 281–300 publications: 939 scientists 301–320 publications: 764 scientists 321–340 publications: 643 scientists 341–360 publications: 628 scientists 361–380 publications: 522 scientists 381–400 publications: 459 scientists 401–420 publications: 397 scientists 421–440 publications: 327 scientists 441–460 publications: 270 scientists 461–480 publications: 265 scientists 481–500 publications: 252 scientists 501–520 publications: 201 scientists 521–540 publications: 185 scientists 541–560 publications: 148 scientists 561–580 publications: 148 scientists 581–600 publications: 132 scientists 601–620 publications: 114 scientists 621–640 publications: 104 scientists 641–660 publications: 91 scientists 661–680 publications: 92 scientists 681–700 publications: 73 scientists 701–720 publications: 57 scientists 721–740 publications: 54 scientists 741–760 publications: 67 scientists 761–780 publications: 45 scientists 781–800 publications: 46 scientists 801–820 publications: 39 scientists 821–840 publications: 32 scientists 841–860 publications: 36 scientists 861–880 publications: 29 scientists 881–900 publications: 26 scientists 901–920 publications: 24 scientists 921–940 publications: 14 scientists 941–960 publications: 23 scientists 961–980 publications: 28 scientists 981–1,000 publications: 15 scientists 1,001–1,020 publications: 29 scientists 1,021–1,040 publications: 12 scientists 1,041–1,060 publications: 19 scientists 1,061–1,080 publications: 12 scientists 1,081–1,100 publications: 6 scientists 1,101–1,120 publications: 8 scientists 1,121–1,140 publications: 12 scientists 1,141–1,160 publications: 5 scientists 1,161–1,180 publications: 6 scientists 1,181–1,200 publications: 14 scientists 1,201–1,220 publications: 7 scientists 1,221–1,240 publications: 2 scientists 1,241–1,260 publications: 6 scientists 1,261–1,280 publications: 4 scientists 1,281–1,294 publications: 6 scientists 1,295+ publications: 100 scientists
61 publications 1,295+

This scientist: 599 publications — 93rd percentile

93% of scientists in this discipline score the same or lower.

The last bar groups every scientist with 1,295 publications or more.

Brian D. Sykes D-index placement in Chemistry in 2026

The chart shows the D-index (discipline H-index) distribution of Chemistry scientists ranked by Research.com in 2026. The highlighted bar marks where Brian D. Sykes sits on this spectrum.

40–41 D-Index: 289 scientists 42–43 D-Index: 612 scientists 44–45 D-Index: 808 scientists 46–47 D-Index: 776 scientists 48–49 D-Index: 835 scientists 50–51 D-Index: 861 scientists 52–53 D-Index: 872 scientists 54–55 D-Index: 933 scientists 56–57 D-Index: 1,051 scientists 58–59 D-Index: 930 scientists 60–61 D-Index: 882 scientists 62–63 D-Index: 834 scientists 64–65 D-Index: 731 scientists 66–67 D-Index: 775 scientists 68–69 D-Index: 683 scientists 70–71 D-Index: 646 scientists 72–73 D-Index: 561 scientists 74–75 D-Index: 501 scientists 76–77 D-Index: 437 scientists 78–79 D-Index: 388 scientists 80–81 D-Index: 354 scientists 82–83 D-Index: 292 scientists 84–85 D-Index: 275 scientists 86–87 D-Index: 254 scientists 88–89 D-Index: 235 scientists 90–91 D-Index: 185 scientists 92–93 D-Index: 192 scientists 94–95 D-Index: 155 scientists 96–97 D-Index: 163 scientists 98–99 D-Index: 125 scientists 100–101 D-Index: 105 scientists 102–103 D-Index: 105 scientists 104–105 D-Index: 112 scientists 106–107 D-Index: 88 scientists 108–109 D-Index: 68 scientists 110–111 D-Index: 69 scientists 112–113 D-Index: 65 scientists 114–115 D-Index: 79 scientists 116–117 D-Index: 61 scientists 118–119 D-Index: 44 scientists 120–121 D-Index: 37 scientists 122–123 D-Index: 40 scientists 124–125 D-Index: 33 scientists 126–127 D-Index: 26 scientists 128–129 D-Index: 34 scientists 130–131 D-Index: 35 scientists 132–133 D-Index: 25 scientists 134–135 D-Index: 27 scientists 136–137 D-Index: 17 scientists 138–139 D-Index: 16 scientists 140–141 D-Index: 20 scientists 142–143 D-Index: 20 scientists 144–145 D-Index: 15 scientists 146–147 D-Index: 9 scientists 148–149 D-Index: 9 scientists 150–151 D-Index: 16 scientists 152–153 D-Index: 11 scientists 154–155 D-Index: 9 scientists 156–157 D-Index: 3 scientists 158 D-Index: 3 scientists 159+ D-Index: 98 scientists
40 D-Index 159+

This scientist: 100 D-Index — 93rd percentile

93% of scientists in this discipline score the same or lower.

The last bar groups every scientist with 159 D-Index or more.

Research.com Recognitions

  • 2025 - Research.com Chemistry in Canada Leader Award
  • 2022 - Research.com Chemistry in Canada Leader Award

Overview

Brian D. Sykes is affiliated with the University of Alberta in Canada, where their research encompasses a range of topics within medicine and biochemistry. Their work includes significant contributions in cardiology and cardiovascular medicine as well as molecular biology, particularly focused on the mechanisms of muscle function and related biochemical processes.

The scientist's recent publications cover various specialized fields and have appeared in multiple journals. Notable papers include:

  • Structural Basis of Tirasemtiv Activation of Fast Skeletal Muscle, 2021, Journal of Medicinal Chemistry
  • Optimizing fluorine labelling for 19F solid-state NMR in oriented biological systems, 2020, Journal of Biomolecular NMR
  • The Role of Electrostatics in the Mechanism of Cardiac Thin Filament Based Sensitizers, 2020, ACS Chemical Biology
  • Conversion of a Cardiac Muscle Modulator from an Inhibitor to an Activator, 2023, ACS Medicinal Chemistry Letters
  • Metabolomic study of disease progression in scrapie prion infected mice; validation of a novel method for brain metabolite extraction, 2020, Metabolomics

Their frequent coauthors include colleagues with expertise in related fields. Some coauthors with multiple collaborations are Fangze Cai, Thomas Kampourakis, Kieran T. Cockburn, Ian M. Robertson, and Brittney A. Klein.

The research has been published primarily in venues such as:

  • ACS Medicinal Chemistry Letters
  • Journal of Biomolecular NMR
  • ACS Chemical Biology
  • Biophysical Journal
  • bioRxiv (Cold Spring Harbor Laboratory)

Main fields of study for the scientist are centered around medicine, with 22 publications, and biochemistry, genetics, and molecular biology, with 12 publications. Subfields of particular focus include cardiology and cardiovascular medicine, molecular biology, spectroscopy, radiology and nuclear medicine, and biophysics.

The primary topics of their research work include:

  • Cardiomyopathy and Myosin Studies
  • Advanced NMR Techniques and Applications
  • Electron Spin Resonance Studies
  • Force Microscopy Techniques and Applications
  • RNA and protein synthesis mechanisms
  • Cardiovascular Function and Risk Factors
  • Pancreatic function and diabetes

Best Publications

  • HMDB: The human metabolome database

    David S. Wishart;Dan Tzur;Craig Knox;Roman Eisner

  • 1H, 13C and 15N chemical shift referencing in biomolecular NMR

    D S Wishart;C G Bigam;J Yao;F Abildgaard

  • The chemical shift index: A fast and simple method for the assignment of protein secondary structure through NMR spectroscopy

    D. S. Wishart;B. D. Sykes;F. M. Richards

  • The 13C chemical-shift index: a simple method for the identification of protein secondary structure using 13C chemical-shift data.

    David S. Wishart;Brian D. Sykes

  • Relationship between nuclear magnetic resonance chemical shift and protein secondary structure.

    D.S. Wishart;B.D. Sykes;F.M. Richards

  • 1H, 13C and 15N random coil NMR chemical shifts of the common amino acids. I. Investigations of nearest-neighbor effects.

    David S. Wishart;Colin G. Bigam;Arne Holm;Robert S. Hodges

  • Chemical shifts as a tool for structure determination.

    David S Wishart;Brian D Sykes

  • VADAR: a web server for quantitative evaluation of protein structure quality

    Leigh Willard;Anuj Ranjan;Haiyan Zhang;Hassan Monzavi

  • Solution structure and basis for functional activity of stromal cell-derived factor-1; dissociation of CXCR4 activation from binding and inhibition of HIV-1.

    Matthew P. Crump;Jiang Hong Gong;Pius Loetscher;Krishna Rajarathnam

  • Effect of trifluoroethanol on protein secondary structure: an NMR and CD study using a synthetic actin peptide.

    F. D. Sonnichsen;J. E. Van Eyk;R. S. Hodges;B. D. Sykes

  • Recommendations for the presentation of NMR structures of proteins and nucleic acids

    John L. Markley;Ad Bax;Yoji Arata;C. W. Hilbers

  • Recommendations for the presentation of NMR structures of proteins and nucleic acids. IUPAC-IUBMB-IUPAB Inter-Union Task Group on the Standardization of Data Bases of Protein and Nucleic Acid Structures Determined by NMR Spectroscopy.

    John L. Markley;Ad Bax;Yoji Arata;C. W. Hilbers

  • 1H, 13C and 15N random coil NMR chemical shifts of the common amino acids. I. Investigations of nearest-neighbor effects

    Unknown

  • β-Helix structure and ice-binding properties of a hyperactive antifreeze protein from an insect

    Steffen P. Graether;Steffen P. Graether;Michael J. Kuiper;Stéphane M. Gagné;Virginia K. Walker

  • Recommendations for the presentation of NMR structures of proteins and nucleic acids (IUPAC Recommendations 1998)

    John L. Markley;Ad Bax;Yoji Arata;C. W. Hilbers

  • Structure-activity relationships of chemokines.

    Ian Clark-Lewis;Key-Sun Kim;Krishnakumar Rajarathnam;Jiang-Hong Gong

  • Water Eliminated Fourier Transform NMR Spectroscopy

    Steven L. Patt;Brian D. Sykes

  • Neutrophil activation by monomeric interleukin-8

    Krishnakumar Rajarathnam;Brian D. Sykes;Cyril M. Kay;Beatrice Dewald

  • Binding of cardiac troponin-I147-163 induces a structural opening in human cardiac troponin-C.

    Monica X. Li;Leo Spyracopoulos;Brian D. Sykes

  • Measurement of 2H T1 and T1.rho. Relaxation Times in Uniformly 13C-Labeled and Fractionally 2H-Labeled Proteins in Solution

    D. R. Muhandiram;Toshio Yamazaki;Brian D. Sykes;Lewis E. Kay

  • Structures of the troponin C regulatory domains in the apo and calcium-saturated states.

    Stéphane M. Gagné;Sakae Tsuda;Monica X. Li;Lawrence B. Smillie

  • Structural and functional analysis of the Na+/H+ exchanger

    Emily R. Slepkov;Jan K. Rainey;Brian D. Sykes;Larry Fliegel

Frequent Co-Authors

Robert S. Hodges
Robert S. Hodges University of Colorado Denver
Cyril M. Kay
Cyril M. Kay University of Alberta
David S. Wishart
David S. Wishart University of Alberta
Frank D. Sönnichsen
Frank D. Sönnichsen Kiel University
Peter L. Davies
Peter L. Davies Queen's University
Larry Fliegel
Larry Fliegel University of Alberta
Robert O. Ryan
Robert O. Ryan University of Nevada Reno
Lawrence B. Smillie
Lawrence B. Smillie University of Alberta
Matthew P. Crump
Matthew P. Crump University of Bristol
Ian Clark-Lewis
Ian Clark-Lewis University of British Columbia

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