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D-Index & Metrics

Chemistry

D-Index
56
Citations
9736
World Ranking
11799
National Ranking
3173

Biology and Biochemistry

D-Index
59
Citations
10508
World Ranking
12738
National Ranking
5429

Overview

Randal A. Skidgel is affiliated with the University of Illinois at Chicago in the United States. Their research spans multiple fields primarily within medicine and biochemistry, genetics, and molecular biology.

The main areas of study for Skidgel include immunology and allergy, genetics, oncology, hematology, and immunology as subfields. Their work extensively covers topics such as cell adhesion molecules research, peptidase inhibition and analysis, platelet disorders and treatments, neuropeptides and animal physiology, blood disorders and treatments, protease and inhibitor mechanisms, and immune response and inflammation.

Skidgel has published a number of papers in notable scientific journals. These recent papers include:

  • High-loading Gα 13-binding EXE peptide nanoparticles prevent thrombosis and protect mice from cardiac ischemia/reperfusion injury, 2020, Science Translational Medicine
  • Targeting Gα13-integrin interaction ameliorates systemic inflammation, 2021, Nature Communications
  • Integrin β3 directly inhibits the Gα13-p115RhoGEF interaction to regulate G protein signaling and platelet exocytosis, 2023, Nature Communications
  • Gα13 Mediates Transendothelial Migration of Neutrophils by Promoting Integrin-Dependent Motility without Affecting Directionality, 2021, The Journal of Immunology
  • Ervin G. Erdös, MD, (October 16, 1922-November 17, 2019), 2020, Hypertension

The frequent co-authors collaborating with Skidgel include Ni Cheng, Yanyan Bai, Xiaoping Du, Claire Chang, and Can Wang.

Skidgel's research has been featured predominantly in several publication venues, notably:

  • Nature Communications
  • Science Translational Medicine
  • The Journal of Immunology
  • Hypertension
  • Blood

Best Publications

  • Neutral endopeptidase 24.11 (enkephalinase) and related regulators of peptide hormones

    Ervin G. Erdös;Randal A. Skidgel

  • Hydrolysis of substance p and neurotensin by converting enzyme and neutral endopeptidase

    Randal A. Skidgel;Siegfried Engelbrecht;Alice R. Johnson;Ervin G. Erdös

  • N-Domain–Specific Substrate and C-Domain Inhibitors of Angiotensin-Converting Enzyme: Angiotensin-(1–7) and Keto-ACE

    Peter A. Deddish;Branislav Marcic;Herbert L. Jackman;Huan Zhu Wang

  • Human kidney "enkephalinase", a neutral metalloendopeptidase that cleaves active peptides.

    John T. Gafford;Randal A. Skidgel;Ervin G. Erdos;Louis B. Hersh

  • Basic carboxypeptidases: regulators of peptide hormone activity

    Randal A. Skidgel

  • Neutral endopeptidase 24.11 in human neutrophils: cleavage of chemotactic peptide

    Jon C. Connelly;Randal A. Skidgel;Werner W. Schulz;Alice R. Johnson

  • Reversal of type 1 diabetes via islet β cell regeneration following immune modulation by cord blood-derived multipotent stem cells

    Yong Zhao;Zhaoshun Jiang;Tingbao Zhao;Mingliang Ye

  • A peptidase in human platelets that deamidates tachykinins. Probable identity with the lysosomal "protective protein".

    Herbert L. Jackman;Fulong Tan;Hironori Tamei;Christina Beurling-Harbury

  • The broad substrate specificity of human angiotensin I converting enzyme.

    Randal A. Skidgel;Ervin G. Erdös

  • Angiotensin converting enzyme (ACE) and neprilysin hydrolyze neuropeptides: a brief history, the beginning and follow-ups to early studies.

    Randal A Skidgel;Ervin G Erdös

  • Human carboxypeptidase M. Purification and characterization of a membrane-bound carboxypeptidase that cleaves peptide hormones.

    R. A. Skidgel;R. M. Davis;Fulong Tan

  • Differential regulation of inducible and endothelial nitric oxide synthase by kinin B1 and B2 receptors.

    F. Kuhr;J. Lowry;Y. Zhang;V. Brovkovych

  • Angiotensin I–Converting Enzyme Inhibitors Are Allosteric Enhancers of Kinin B1 and B2 Receptor Function

    Ervin G. Erdös;Fulong Tan;Randal A. Skidgel

  • Novel activity of human angiotensin I converting enzyme: release of the NH2- and COOH-terminal tripeptides from the luteinizing hormone-releasing hormone

    Randal A. Skidgel;Ervin G. Erdos

  • Novel Mechanism of Endothelial Nitric Oxide Synthase Activation Mediated by Caveolae Internalization in Endothelial Cells

    Nikolaos A. Maniatis;Viktor Brovkovych;Scott E. Allen;Theresa A. John

  • Novel mode of action of angiotensin I converting enzyme inhibitors: direct activation of bradykinin B1 receptor.

    Tatjana Ignjatovic;Fulong Tan;Viktor Brovkovych;Randal A. Skidgel

  • Sequencing and cloning of human prolylcarboxypeptidase (angiotensinase C). Similarity to both serine carboxypeptidase and prolylendopeptidase families.

    Fulong Tan;Paul W. Morris;Randal A. Skidgel;Ervin G. Erdös

  • Hydrolysis of opioid hexapeptides by carboxypeptidase N: Presence of carboxypeptidase in cell membranes

    Randal A. Skidgel;Alice R. Johnson;Ervin G. Erdös

  • Nitric oxide-dependent Src activation and resultant caveolin-1 phosphorylation promote eNOS/caveolin-1 binding and eNOS inhibition.

    Zhenlong Chen;Farnaz R. Bakhshi;Ayesha N. Shajahan;Tiffany Sharma

  • Molecular cloning and sequencing of the cDNA for human membrane-bound carboxypeptidase M. Comparison with carboxypeptidases A, B, H, and N.

    Fulong Tan;Shu Jin Chan;D. F. Steiner;J. W. Schilling

  • Bradykinin-Degrading Enzymes: Structure, Function, Distribution, and Potential Roles in Cardiovascular Pharmacology

    Randal A. Skidgel

  • Cellular carboxypeptidases

    Unknown

Frequent Co-Authors

Ervin G. Erdös
Ervin G. Erdös University of Illinois at Chicago
Richard D. Minshall
Richard D. Minshall University of Illinois at Chicago
Asrar B. Malik
Asrar B. Malik University of Illinois at Chicago
Xiaoping Du
Xiaoping Du University of Illinois at Chicago
Michael Rehli
Michael Rehli University of Regensburg
William B. Campbell
William B. Campbell Medical College of Wisconsin
Stephen M. Vogel
Stephen M. Vogel University of Illinois at Chicago
Nissim Hay
Nissim Hay University of Illinois at Chicago
Chinnaswamy Tiruppathi
Chinnaswamy Tiruppathi University of Illinois at Chicago
Klaus Maskos
Klaus Maskos Proteros biostructures GmbH

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