D-Index & Metrics Best Publications

D-Index & Metrics D-index (Discipline H-index) only includes papers and citation values for an examined discipline in contrast to General H-index which accounts for publications across all disciplines.

Discipline name D-index D-index (Discipline H-index) only includes papers and citation values for an examined discipline in contrast to General H-index which accounts for publications across all disciplines. Citations Publications World Ranking National Ranking
Biology and Biochemistry D-index 76 Citations 19,019 320 World Ranking 3177 National Ranking 1642

Overview

What is he best known for?

The fields of study he is best known for:

  • Enzyme
  • Gene
  • Amino acid

Louis B. Hersh mainly investigates Choline acetyltransferase, Biochemistry, Cholinergic neuron, Cholinergic and Neuroscience. The study incorporates disciplines such as Anatomy and Nerve growth factor in addition to Choline acetyltransferase. His research related to Enzyme, Peptide, Aminopeptidase, Cleavage and Enkephalinase might be considered part of Biochemistry.

The Enzyme study combines topics in areas such as Hormone and Enkephalin. Louis B. Hersh interconnects Pathology, Caudate nucleus, Nucleus and Basal forebrain in the investigation of issues within Cholinergic neuron. His Neuroscience research incorporates elements of Alzheimer's disease and Acetylcholinesterase.

His most cited work include:

  • Environmental Enrichment Reduces Aβ Levels and Amyloid Deposition in Transgenic Mice (730 citations)
  • Insulin-degrading enzyme regulates extracellular levels of amyloid beta-protein by degradation. (722 citations)
  • Neprilysin Gene Transfer Reduces Human Amyloid Pathology in Transgenic Mice (332 citations)

What are the main themes of his work throughout his whole career to date?

His primary areas of study are Biochemistry, Enzyme, Choline acetyltransferase, Molecular biology and Internal medicine. His study in Enzyme is interdisciplinary in nature, drawing from both Hydrolysis, Methylamine, Stereochemistry and Enkephalin. His Choline acetyltransferase study combines topics from a wide range of disciplines, such as Anatomy and Cholinergic neuron.

His studies in Molecular biology integrate themes in fields like Protein kinase A and Complementary DNA, Regulation of gene expression, Transcription factor, Gene. His Internal medicine research is multidisciplinary, relying on both Endocrinology and Neprilysin. His Neprilysin research is multidisciplinary, incorporating elements of Amyloid beta, Metalloendopeptidase, Cell biology, Genetically modified mouse and Amyloid.

He most often published in these fields:

  • Biochemistry (45.31%)
  • Enzyme (31.56%)
  • Choline acetyltransferase (28.75%)

What were the highlights of his more recent work (between 2003-2021)?

  • Neprilysin (17.19%)
  • Biochemistry (45.31%)
  • Internal medicine (16.87%)

In recent papers he was focusing on the following fields of study:

His primary scientific interests are in Neprilysin, Biochemistry, Internal medicine, Enzyme and Insulin-degrading enzyme. He combines subjects such as Amyloid beta, Amyloid precursor protein, Cell biology, Genetically modified mouse and Amyloid with his study of Neprilysin. His research integrates issues of Molecular biology and Insulin in his study of Biochemistry.

He has researched Internal medicine in several fields, including Endocrinology and Cancer research. His Endocrinology study incorporates themes from Disease and Pathology. His biological study spans a wide range of topics, including Protein structure and Cleavage.

Between 2003 and 2021, his most popular works were:

  • Environmental Enrichment Reduces Aβ Levels and Amyloid Deposition in Transgenic Mice (730 citations)
  • Neprilysin regulates amyloid Beta peptide levels. (136 citations)
  • Choline Acetyltransferase: Celebrating Its Fiftieth Year (136 citations)

In his most recent research, the most cited papers focused on:

  • Enzyme
  • Gene
  • Amino acid

The scientist’s investigation covers issues in Neprilysin, Endocrinology, Internal medicine, Alzheimer's disease and Biochemistry. His research in Neprilysin intersects with topics in Amyloid beta, Amyloid precursor protein, Cell biology, Genetically modified mouse and Amyloid. His Endocrinology research incorporates themes from Enzyme assay and Metalloendopeptidase.

Biochemistry and Ascorbic acid are two areas of study in which he engages in interdisciplinary work. His Binding site study combines topics in areas such as Choline acetyltransferase, Acetylcholine and Cholinergic. His study looks at the relationship between Choline acetyltransferase and topics such as Gene, which overlap with Molecular biology.

This overview was generated by a machine learning system which analysed the scientist’s body of work. If you have any feedback, you can contact us here.

Best Publications

Environmental Enrichment Reduces Aβ Levels and Amyloid Deposition in Transgenic Mice

Orly Lazarov;John Robinson;Ya Ping Tang;Ilana S. Hairston.
Cell (2005)

1067 Citations

Insulin-degrading enzyme regulates extracellular levels of amyloid beta-protein by degradation.

Wei Qiao Qiu;Dominic M. Walsh;Zhen Ye;Konstantinos Vekrellis.
Journal of Biological Chemistry (1998)

1042 Citations

Neprilysin Gene Transfer Reduces Human Amyloid Pathology in Transgenic Mice

Robert A. Marr;Edward Rockenstein;Atish Mukherjee;Mark S. Kindy.
The Journal of Neuroscience (2003)

447 Citations

Amyloid-β peptide levels in brain are inversely correlated with insulysin activity levels in vivo

Bonnie C. Miller;Elizabeth A. Eckman;Kumar Sambamurti;Kumar Sambamurti;Nicole Dobbs.
Proceedings of the National Academy of Sciences of the United States of America (2003)

369 Citations

Human kidney "enkephalinase", a neutral metalloendopeptidase that cleaves active peptides.

John T. Gafford;Randal A. Skidgel;Ervin G. Erdos;Louis B. Hersh.
Biochemistry (1983)

361 Citations

Preservation of nucleus basalis neurons containing choline acetyltransferase and the vesicular acetylcholine transporter in the elderly with mild cognitive impairment and early Alzheimer's disease.

Michelle L. Gilmor;Jeffrey D. Erickson;Hélène Varoqui;Louis B. Hersh.
The Journal of Comparative Neurology (1999)

338 Citations

Effects of Estrogen Replacement on the Relative Levels of Choline Acetyltransferase, trkA, and Nerve Growth Factor Messenger RNAs in the Basal Forebrain and Hippocampal Formation of Adult Rats

Robert B. Gibbs;Donghai Wu;Louis B. Hersh;Donald W. Pfaff.
Experimental Neurology (1994)

334 Citations

Two new proteases in the MHC class I processing pathway

Lars Stoltze;Markus Schirle;Gerold Schwarz;Christian Schröter.
Nature Immunology (2000)

330 Citations

Human reticular formation: Cholinergic neurons of the pedunculopontine and laterodorsal tegmental nuclei and some cytochemical comparisons to forebrain cholinergic neurons

M. Marsel Mesulam;Changiz Geula;Mark A. Bothwell;Louis B. Hersh.
The Journal of Comparative Neurology (1989)

321 Citations

The hydrolysis of endothelins by neutral endopeptidase 24.11 (enkephalinase).

J. Vijayaraghavan;A. G. Scicli;O. A. Carretero;Clive A. Slaughter.
Journal of Biological Chemistry (1990)

319 Citations

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