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Biology and Biochemistry
Australia
2023

D-Index & Metrics

Biology and Biochemistry

D-Index
82
Citations
27235
World Ranking
3658
National Ranking
87

Research.com Recognitions

  • 2023 - Research.com Biology and Biochemistry in Australia Leader Award
  • 2018 - Australian Laureate Fellow

Overview

Bostjan Kobe is affiliated with the University of Queensland in Australia. Their research expertise spans several interconnected fields including Biochemistry, Genetics and Molecular Biology, Medicine, and Immunology and Microbiology. Within these areas, they have notably contributed to subfields such as Immunology, Molecular Biology, Plant Science, Epidemiology, and Physiology.

The scientist's main research topics include:

  • Plant-Microbe Interactions and Immunity
  • Immune Response and Inflammation
  • Neutrophil, Myeloperoxidase and Oxidative Mechanisms
  • Enzyme Structure and Function
  • Biochemical effects in animals
  • Calcium signaling and nucleotide metabolism
  • Antimicrobial Peptides and Activities

Bostjan Kobe's recent publications illustrate their focus on molecular mechanisms and immune signaling. Selected papers include:

  • SARM1 is a metabolic sensor activated by an increased NMN/NAD+ ratio to trigger axon degeneration, 2021, Neuron
  • Cyclic ADP ribose isomers: Production, chemical structures, and immune signaling, 2022, Science
  • Structural basis of SARM1 activation, substrate recognition, and inhibition by small molecules, 2022, Molecular Cell
  • Structural basis of NLR activation and innate immune signalling in plants, 2022, Immunogenetics
  • MyD88 TIR domain higher-order assembly interactions revealed by microcrystal electron diffraction and serial femtosecond crystallography, 2021, Nature Communications

Frequent co-authors in their work include Thomas Ve, Jeffrey D. Nanson, Weixi Gu, M.K. Manik, and Zhenyao Luo, reflecting sustained collaborative efforts over multiple projects.

Their publications have appeared most often in:

  • Acta Crystallographica Section A Foundations and Advances
  • bioRxiv (Cold Spring Harbor Laboratory)
  • Journal of Biological Chemistry
  • Nature Communications
  • New Phytologist

Bostjan Kobe was awarded the Australian Laureate Fellow in 2018.

Best Publications

  • The leucine-rich repeat as a protein recognition motif

    Bostjan Kobe;Andrey V Kajava

  • The leucine-rich repeat: a versatile binding motif.

    Bostjan Kobe;Johann Deisenhofer

  • Direct protein interaction underlies gene-for-gene specificity and coevolution of the flax resistance genes and flax rust avirulence genes

    Peter N. Dodds;Gregory J. Lawrence;Ann-Maree Catanzariti;Trazel Teh

  • A structural basis of the interactions between leucine-rich repeats and protein ligands.

    Bostjan Kobe;Johann Deisenhofer

  • Crystal structure of porcine ribonuclease inhibitor, a protein with leucine-rich repeats

    Bostjan Kobe;Johann Deisenhofer

  • Uses for JNK: the Many and Varied Substrates of the c-Jun N-Terminal Kinases

    Marie A. Bogoyevitch;Bostjan Kobe

  • Proteins with leucine-rich repeats

    Bostjan Kobe;Johann Deisenhofer

  • A Molecular Mechanism for Bacterial Susceptibility to Zinc.

    Christopher A. McDevitt;Abiodun D. Ogunniyi;Eugene Valkov;Michael C. Lawrence

  • Structural basis of recognition of monopartite and bipartite nuclear localization sequences by mammalian importin-alpha

    Marcos R.M. Fontes;Trazel Teh;Bostjan Kobe

  • Autoinhibition by an internal nuclear localization signal revealed by the crystal structure of mammalian importin alpha.

    Bostjan Kobe

  • Molecular basis for specificity of nuclear import and prediction of nuclear localization

    Mary Marfori;Andrew Mynott;Jonathan J. Ellis;Ahmed M. Mehdi

  • NAD+ cleavage activity by animal and plant TIR domains in cell death pathways

    Shane Horsefield;Hayden Burdett;Xiaoxiao Zhang;Xiaoxiao Zhang;Mohammad K. Manik

  • Discovering Sequence Motifs with Arbitrary Insertions and Deletions

    Martin C. Frith;Neil F. W. Saunders;Bostjan Kobe;Timothy L. Bailey

  • Structural Basis for Assembly and Function of a Heterodimeric Plant Immune Receptor

    Simon J. Williams;Kee Hoon Sohn;Kee Hoon Sohn;Li Wan;Maud Bernoux

  • Structural and Functional Analysis of a Plant Resistance Protein TIR Domain Reveals Interfaces for Self-Association, Signaling, and Autoregulation.

    Maud Bernoux;Thomas Ve;Simon Williams;Christopher Warren

  • Crystal structures of fusion proteins with large-affinity tags

    Douglas R. Smyth;Marek K. Mrozkiewicz;William J. McGrath;William J. McGrath;Pawel Listwan;Pawel Listwan

  • When protein folding is simplified to protein coiling: the continuum of solenoid protein structures.

    Bostjan Kobe;Andrey V Kajava

  • Emerging Insights into the Functions of Pathogenesis-Related Protein 1

    Susan Breen;Simon J. Williams;Megan Outram;Bostjan Kobe

  • Crystal structure of human T cell leukemia virus type 1 gp21 ectodomain crystallized as a maltose-binding protein chimera reveals structural evolution of retroviral transmembrane proteins

    Bostjan Kobe;Bruce E. Kemp;Pantelis Poumbourios

  • Structural basis of autoregulation of phenylalanine hydroxylase

    Bostjan Kobe;Ian G. Jennings;Colin M. House;Colin M. House;Belinda J. Michell

Frequent Co-Authors

Peter N. Dodds
Peter N. Dodds Commonwealth Scientific and Industrial Research Organisation
Jennifer L. Martin
Jennifer L. Martin University of Wollongong
Thomas Huber
Thomas Huber Australian National University
David A. Hume
David A. Hume University of Queensland
Bruce E. Kemp
Bruce E. Kemp Australian Catholic University
Jeffrey G. Ellis
Jeffrey G. Ellis Commonwealth Scientific and Industrial Research Organisation
Paul R. Young
Paul R. Young University of Queensland
Brian J. Staskawicz
Brian J. Staskawicz University of California, Berkeley
Ashley Mansell
Ashley Mansell Hudson Institute of Medical Research
Alastair G. McEwan
Alastair G. McEwan University of Queensland

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