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Frederico Guilherme Graeff

Frederico Guilherme Graeff

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Neuroscience
Brazil
2026

D-Index & Metrics

Neuroscience

D-Index
75
Citations
18406
World Ranking
2032
National Ranking
7

Research.com Recognitions

  • 2026 - Research.com Neuroscience in Brazil Leader Award
  • 2025 - Research.com Neuroscience in Brazil Leader Award

Overview

Frederico Guilherme Graeff is affiliated with the Universidade de São Paulo in Brazil and conducts research primarily in the fields of Medicine and Neuroscience. Their work spans areas such as Pharmacology, Cellular and Molecular Neuroscience, Molecular Biology, Biological Psychiatry, and Experimental and Cognitive Psychology.

They focus on topics including:

  • Treatment of Major Depression
  • Neurotransmitter Receptor Influence on Behavior
  • Tryptophan and brain disorders
  • Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
  • Pharmacological Receptor Mechanisms and Effects
  • Menstrual Health and Disorders
  • Perfectionism, Procrastination, Anxiety Studies

Among their recent scientific contributions are the following papers:

  • "Antipanic-like effect of esketamine and buprenorphine in rats exposed to acute hypoxia," 2021, published in Behavioural Brain Research
  • "Low doses of fluoxetine for the treatment of emotional premenstrual syndrome: a randomized double-blind, placebo-controlled, pilot study," 2023, published in Psychoneuroendocrinology
  • "Bradykinin actions in the central nervous system: historical overview and psychiatric implications," 2024, published in Acta Neuropsychiatrica
  • "Investigating novel pharmacological strategies for treatment-resistant depression: focus on new mechanisms and approaches," 2025, published in Expert Opinion on Drug Discovery
  • "Effect of tramadol as an adjunctive pharmacological treatment for major depressive disorder: a randomised, double-blind, placebo-controlled trial," 2023, published in Neuroscience Applied

Their frequent co-authors include:

  • Cristina Marta Del-Ben (4 joint publications)
  • Hélio Zangrossi (3 joint publications)
  • Sâmia Joca (2 joint publications)
  • André Campiolo Boin (2 joint publications)
  • Camila Marcelino Loureiro (2 joint publications)

Frederico Guilherme Graeff has published repeatedly in specialized journals such as Behavioural Brain Research, Psychoneuroendocrinology, Acta Neuropsychiatrica, Expert Opinion on Drug Discovery, and Neuroscience Applied.

Best Publications

  • Role of 5-HT in stress, anxiety, and depression

    Frederico Guilherme Graeff;Francisco Silveira Guimarães;T G C S De Andrade;J F W Deakin

  • 5-HT and mechanisms of defence.

    J. F. William Deakin;Frederico G. Graeff

  • Ethopharmacological analysis of rat behavior on the elevated plus-maze

    A.P.M. Cruz;F. Frei;F.G. Graeff

  • The elevated T-maze as an experimental model of anxiety

    Frederico G Graeff;Cristina Ferreira Netto;Hélio Zangrossi

  • Effects of ipsapirone and cannabidiol on human experimental anxiety.

    A W Zuardi;R A Cosme;F G Graeff;F S Guimarães

  • Antianxiety effect of cannabidiol in the elevated plus-maze

    Francisco Silveira Guimarães;T M Chiaretti;Frederico Guilherme Graeff;A W Zuardi

  • Neuroanatomy and neurotransmitter regulation of defensive behaviors and related emotions in mammals

    Graeff Fg

  • Serotonin, the periaqueductal gray and panic.

    Frederico G Graeff

  • Role of the amygdala and periaqueductal gray in anxiety and panic

    Frederico G. Graeff;Maria Cristina L. Silveira;Regina L. Nogueira;Elisabeth A. Audi

  • Induction of Fos immunoreactivity in the brain by exposure to the elevated plus-maze

    Maria Cristina L. Silveira;Guy Sandner;Frederico G. Graeff

  • The elevated T-maze: a new animal model of anxiety and memory.

    M.B. Viana;C. Tomaz;F.G. Graeff

  • On serotonin and experimental anxiety.

    Frederico G Graeff

  • The elevated T maze, a new experimental model of anxiety and memory: effect of diazepam.

    F G Graeff;M B Viana;C Tomaz

  • Behavioral effects of acute and chronic imipramine in the elevated T-maze model of anxiety.

    Rafael Custódio Teixeira;Hélio Zangrossi;Frederico G Graeff

  • Trial 2 in the elevated plus-maze: a different form of fear?

    Sandra E. File;Helio Zangrossi;Milena Viana;Frederico G. Graeff

  • GABA mediation of the anti-aversive action of minor tranquilizers☆

    M.L. Brandão;J.C. De Aguiar;F.G. Graeff

  • Dual role of 5-HT in defense and anxiety

    Frederico G. Graeff;Milena B. Viana;Paula O. Mora

  • Behavioral Validation of the Elevated T-Maze, a New Animal Model of Anxiety

    Hélio Zangrossi;Frederico G Graeff

  • Neurobiology of panic disorder: from animal models to brain neuroimaging.

    Frederico G. Graeff;Cristina M. Del-Ben

  • Anti-aversive role of serotonin in the dorsal periaqueductal grey matter.

    M. T. B. Schütz;J. C. de Aguiar;F. G. Graeff

  • Regional gray matter abnormalities in panic disorder: A voxel-based morphometry study

    Ricardo R. Uchida;Cristina M. Del-Ben;Geraldo F. Busatto;Fábio L.S. Duran

  • Anxiolytic effect in the elevated plus-maze of the NMDA receptor antagonist AP7 microinjected into the dorsal periaqueductal grey

    F. S. Guimarães;A. P. Carobrez;J. C. De Aguiar;F. G. Graeff

Frequent Co-Authors

Hélio Zangrossi
Hélio Zangrossi Universidade de São Paulo
Francisco Silveira Guimarães
Francisco Silveira Guimarães Universidade de São Paulo
Marcus Lira Brandão
Marcus Lira Brandão Universidade de São Paulo
Carlos Tomaz
Carlos Tomaz University of Brasília
Norberto Cysne Coimbra
Norberto Cysne Coimbra Universidade de São Paulo
John Francis William Deakin
John Francis William Deakin University of Manchester
Verner Knott
Verner Knott University of Ottawa
Mario Francisco Juruena
Mario Francisco Juruena King's College London
Jean-Marie Danion
Jean-Marie Danion University of Strasbourg
Flávia de Lima Osório
Flávia de Lima Osório Universidade de São Paulo

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