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D-Index & Metrics

Biology and Biochemistry

D-Index
66
Citations
17971
World Ranking
8566
National Ranking
3848

Overview

H. Alex Brown was affiliated with Vanderbilt University in the United States. Their research spanned multiple areas within biochemistry, genetics, and molecular biology, with six publications in these main fields of study. The scientist contributed notably to subfields such as molecular biology, genetics, cancer research, ecology, and radiology, nuclear medicine, and imaging.

Their work addressed several key topics, including:

  • Congenital heart defects research
  • Connective tissue disorders research
  • Genomics and rare diseases
  • Bacteriophages and microbial interactions
  • Monoclonal and polyclonal antibodies research
  • Microbial infections and disease research
  • Cancer, lipids, and metabolism

Frequent coauthors in their publications included Najim Lahrouchi, Alex V. Postma, Christian Salazar, Daniel M. De Laughter, and Fleur V.Y. Tjong.

The scientist published in several venues, with each venue hosting at least one publication. These venues included:

  • Journal of Clinical Investigation
  • Viruses
  • Neuro-Oncology
  • Journal of Visualized Experiments

Some of their recent papers demonstrated the breadth of their research focus:

  • "Biallelic loss-of-function variants in PLD1 cause congenital right-sided cardiac valve defects and neonatal cardiomyopathy," 2021, Journal of Clinical Investigation
  • "Characterization of Lactobacilli Phage Endolysins and Their Functional Domains-Potential Live Biotherapeutic Testing Reagents," 2023, Viruses
  • "TAMI-18. DIFFERENTIAL LIPID METABOLISM IN CANCER MICROENVIRONMENTS LEADS TO A REQUIREMENT FOR FATTY ACID DESATURASES FADS1 AND FADS2 IN GBM CANCER STEM CELL MAINTENANCE," 2021, Neuro-Oncology
  • "Measurement of Cyclic Guanosine Monophosphate (cGMP) in Solid Tissues using Competitive Enzyme-Linked Immunosorbent Assay (ELISA)," 2025, Journal of Visualized Experiments

Best Publications

  • A comprehensive classification system for lipids

    Eoin Fahy;Shankar Subramaniam;H. Alex Brown;Christopher K. Glass

  • ADP-ribosylation factor, a small GTP-dependent regulatory protein, stimulates phospholipase D activity

    H. Alex Brown;Stephen Gutowski;Carolyn R. Moomaw;Clive A. Slaughter

  • Regulated Accumulation of Desmosterol Integrates Macrophage Lipid Metabolism and Inflammatory Responses

    Nathanael J. Spann;Lana X. Garmire;Jeffrey G. McDonald;David S. Myers

  • Evidence that phospholipase D mediates ADP ribosylation factor-dependent formation of Golgi coated vesicles.

    N T Ktistakis;H A Brown;M G Waters;P C Sternweis

  • Phospholipase D - enzymology, functionality, and chemical modulation

    Paige E. Selvy;Robert R. Lavieri;Craig W. Lindsley;H. Alex Brown

  • Biomarkers of NAFLD progression: a lipidomics approach to an epidemic

    D. Lee Gorden;David S. Myers;Pavlina T. Ivanova;Eoin Fahy

  • The TMAO-Generating Enzyme Flavin Monooxygenase 3 Is a Central Regulator of Cholesterol Balance.

    Manya Warrier;Diana M. Shih;Amy C. Burrows;Daniel Ferguson

  • Adiponutrin functions as a nutritionally regulated lysophosphatidic acid acyltransferase.

    Manju Kumari;Gabriele Schoiswohl;Gabriele Schoiswohl;Chandramohan Chitraju;Margret Paar

  • A Mouse Macrophage Lipidome

    Edward A. Dennis;Raymond A. Deems;Richard Harkewicz;Oswald Quehenberger

  • Phospholipase D Signaling Pathways and Phosphatidic Acid as Therapeutic Targets in Cancer

    Ronald C. Bruntz;Craig W. Lindsley;H. Alex Brown

  • Design of isoform-selective phospholipase D inhibitors that modulate cancer cell invasiveness

    Sarah A Scott;Paige E Selvy;Jason R Buck;Hyekyung P Cho

  • Regulation of Phospholipase D by Protein Kinase C Is Synergistic with ADP-ribosylation Factor and Independent of Protein Kinase Activity

    William D. Singer;H. Alex Brown;Xuejun Jiang;Paul C. Sternweis

  • Chronic overexpression of PNPLA3 I148M in mouse liver causes hepatic steatosis

    John Zhong Li;Yongcheng Huang;Ruchan Karaman;Pavlina T. Ivanova

  • Phospholipase D is present on Golgi-enriched membranes and its activation by ADP ribosylation factor is sensitive to brefeldin A

    N T Ktistakis;H A Brown;P C Sternweis;M G Roth

  • Lipidomics: an analysis of cellular lipids by ESI-MS.

    Stephen Milne;Pavlina Ivanova;Jeffrey Forrester;H. Alex Brown

  • Subcellular organelle lipidomics in TLR-4-activated macrophages,

    Alexander Y. Andreyev;Eoin Fahy;Ziqiang Guan;Samuel Kelly

  • Targeting phospholipase D in cancer, infection and neurodegenerative disorders

    H. Alex Brown;Paul G. Thomas;Craig W. Lindsley

  • PLD1 Regulates mTOR Signaling and Mediates Cdc42 Activation of S6K1

    Yimin Fang;In Hyun Park;Ai Luen Wu;Guangwei Du

  • Glycerophospholipid identification and quantitation by electrospray ionization mass spectrometry.

    Pavlina T. Ivanova;Stephen B. Milne;Mark O. Byrne;Yun Xiang

  • Partial Purification and Characterization of Arf-sensitive Phospholipase D from Porcine Brain

    H. A. Brown;S. Gutowski;R. A. Kahn;P. C. Sternweis

Frequent Co-Authors

Craig W. Lindsley
Craig W. Lindsley Vanderbilt University
Paul G. Thomas
Paul G. Thomas St. Jude Children's Research Hospital
Shankar Subramaniam
Shankar Subramaniam University of California, San Diego
Robert C. Murphy
Robert C. Murphy University of Colorado Denver
David W. Russell
David W. Russell University of Washington
Edward A. Dennis
Edward A. Dennis University of California, San Diego
Lawrence J. Marnett
Lawrence J. Marnett Vanderbilt University
Christopher K. Glass
Christopher K. Glass University of California, San Diego
Alfred H. Merrill
Alfred H. Merrill Georgia Institute of Technology
Jeffrey G. McDonald
Jeffrey G. McDonald The University of Texas Southwestern Medical Center

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