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Rafick P. Sekaly

Rafick P. Sekaly

D-Index & Metrics

Immunology

D-Index
73
Citations
21915
World Ranking
2119
National Ranking
1031

Overview

What is he best known for?

The fields of study he is best known for:

  • Immune system
  • Gene
  • Virus

His scientific interests lie mostly in Immunology, Virology, T cell, Antigen and Interleukin 21. His Viral replication, Immune system and T-cell receptor study are his primary interests in Immunology. His Virology study incorporates themes from Human leukocyte antigen and Major histocompatibility complex.

His Antigen research incorporates elements of Molecular biology and Viral load. Interleukin 21 is a subfield of Cytotoxic T cell that Rafick Pierre Sekaly studies. He combines subjects such as Cell biology, IL-2 receptor, CCL5 and Antigen-presenting cell with his study of CD8.

His most cited work include:

  • Upregulation of PD-1 expression on HIV-specific CD8 + T cells leads to reversible immune dysfunction (1242 citations)
  • Upregulation of PD-1 expression on HIV-specific CD8 + T cells leads to reversible immune dysfunction (1242 citations)
  • Skewed maturation of memory HIV-specific CD8 T lymphocytes (959 citations)

What are the main themes of his work throughout his whole career to date?

Rafick Pierre Sekaly mainly focuses on Immunology, Virology, T cell, Immune system and Cytotoxic T cell. His research in Virology intersects with topics in Interleukin 2 and CTL*. He works mostly in the field of Interleukin 2, limiting it down to concerns involving Interferon gamma and, occasionally, Interleukin.

His T cell study integrates concerns from other disciplines, such as Receptor, Peripheral blood mononuclear cell and Antigen. While the research belongs to areas of Cytotoxic T cell, Rafick Pierre Sekaly spends his time largely on the problem of Cancer research, intersecting his research to questions surrounding Stem cell. His Interleukin 21 study frequently links to other fields, such as IL-2 receptor.

He most often published in these fields:

  • Immunology (78.87%)
  • Virology (44.37%)
  • T cell (40.14%)

What were the highlights of his more recent work (between 2013-2021)?

  • Immunology (78.87%)
  • Virology (44.37%)
  • Immune system (29.58%)

In recent papers he was focusing on the following fields of study:

The scientist’s investigation covers issues in Immunology, Virology, Immune system, Cancer research and Inflammation. Rafick Pierre Sekaly combines topics linked to Cytotoxic T cell with his work on Immunology. The study incorporates disciplines such as Proliferative capacity and Antigen in addition to Cytotoxic T cell.

His work on Viremia as part of general Virology research is frequently linked to Nonhuman primate, Cocaine use, Proviral dna and Heroin, bridging the gap between disciplines. His Inflammation study which covers Pathogenesis that intersects with Macrophage and Interferon. His study explores the link between Interleukin 21 and topics such as IL-2 receptor that cross with problems in CD28, Antigen-presenting cell and Natural killer T cell.

Between 2013 and 2021, his most popular works were:

  • Normalizing the environment recapitulates adult human immune traits in laboratory mice (541 citations)
  • CD4+ T Cells Expressing PD-1, TIGIT and LAG-3 Contribute to HIV Persistence during ART (191 citations)
  • Sequential Infection with Common Pathogens Promotes Human-like Immune Gene Expression and Altered Vaccine Response (121 citations)

In his most recent research, the most cited papers focused on:

  • Immune system
  • Gene
  • Virus

His primary areas of investigation include Immunology, Immune system, Immunity, T cell and Virology. Rafick Pierre Sekaly usually deals with Immunology and limits it to topics linked to Lymph and Cellular compartment. His Immune system research is multidisciplinary, relying on both Specific-pathogen-free, Specific Pathogen Free Organism, Blood cell and Laboratory mouse.

He has included themes like Virus latency, Cytotoxic T cell and Cytokine in his T cell study. His Cytokine research includes elements of Interleukin 12, Cell biology, IL-2 receptor and CD8. His Interleukin 21 study is focused on Antigen in general.

Best Publications

  • Upregulation of PD-1 expression on HIV-specific CD8 + T cells leads to reversible immune dysfunction

    Lydie Trautmann;Loury Janbazian;Loury Janbazian;Nicolas Chomont;Elias A. Said

  • Skewed maturation of memory HIV-specific CD8 T lymphocytes

    P Champagne;G S Ogg;A S King;C Knabenhans

  • Normalizing the environment recapitulates adult human immune traits in laboratory mice

    Lalit K. Beura;Sara E. Hamilton;Kevin Bi;Jason M. Schenkel

  • Major expansion of CD8+ T cells with a predominant V beta usage during the primary immune response to HIV.

    G Pantaleo;J F Demarest;H Soudeyns;C Graziosi

  • Early activation of caspases during T lymphocyte stimulation results in selective substrate cleavage in nonapoptotic cells.

    Antoine Alam;Luchino Y. Cohen;Salah Aouad;Rafick-Pierre Sékaly

  • HIV-1 Viremia Prevents the Establishment of Interleukin 2–producing HIV-specific Memory CD4+ T Cells Endowed with Proliferative Capacity

    Souheil Antoine Younes;Bader Yassine-Diab;Alam R. Dumont;Alam R. Dumont;Mohamed Rachid Boulassel

  • Activation of HIV transcription with short-course vorinostat in HIV-infected patients on suppressive antiretroviral therapy.

    Julian H. Elliott;Fiona Wightman;Ajantha Solomon;Khader Ghneim

  • Lack of evidence for the dichotomy of TH1 and TH2 predominance in HIV-infected individuals

    Cecilia Graziosi;Giuseppe Pantaleo;Kira R. Gantt;Jean-Pierre Fortin

  • Influence of HLA-B57 on clinical presentation and viral control during acute HIV-1 infection.

    Marcus Altfeld;Marylyn M. Addo;Eric S. Rosenberg;Frederick M. Hecht

  • CD4+ T Cells Expressing PD-1, TIGIT and LAG-3 Contribute to HIV Persistence during ART

    Rémi Fromentin;Wendy Bakeman;Mariam B. Lawani;Gabriela Khoury;Gabriela Khoury

  • Peripheral Blood CCR4 + CCR6 + and CXCR3 + CCR6 + CD4 + T Cells Are Highly Permissive to HIV-1 Infection

    Annie Gosselin;Patricia Monteiro;Nicolas Chomont;Felipe Diaz-Griffero

  • Barriers to a cure for HIV: new ways to target and eradicate HIV-1 reservoirs

    Christine Katlama;Steven G Deeks;Brigitte Autran;Javier Martinez-Picado

  • The qualitative nature of the primary immune response to HIV infection is a prognosticator of disease progression independent of the initial level of plasma viremia

    Giuseppe Pantaleo;James F. Demarest;Timothy Schacker;Mauro Vaccarezza

  • Synthetic double-stranded RNA induces innate immune responses similar to a live viral vaccine in humans

    Marina Caskey;François Lefebvre;Abdelali Filali-Mouhim;Mark J. Cameron

  • Substantial differences in specificity of HIV-specific cytotoxic T cells in acute and chronic HIV infection.

    Philip J.R. Goulder;Philip J.R. Goulder;Marcus A. Altfeld;Eric S. Rosenberg;Thi Nguyen

  • HIV Infection Rapidly Induces and Maintains a Substantial Suppression of Thymocyte Proliferation

    Marie Lise Dion;Jean François Poulin;Rebeka Bordi;Myriam Sylvestre

  • Restricted dendritic cell and monocyte progenitors in human cord blood and bone marrow

    Jaeyop Lee;Gaëlle Breton;Thiago Yukio Kikuchi Oliveira;Yu Jerry Zhou

  • Direct Evidence for Thymic Function in Adult Humans

    Jean François Poulin;Mohan N. Viswanathan;Jeffrey M. Harris;Krishna V. Komanduri

  • A Novel Assay to Measure the Magnitude of the Inducible Viral Reservoir in HIV-infected Individuals

    Francesco Andrea Procopio;Rémi Fromentin;Deanna A. Kulpa;Jessica H. Brehm

  • Standardization of cytokine flow cytometry assays

    Holden T Maecker;Aline Rinfret;Patricia D'Souza;Janice Darden

Frequent Co-Authors

Jean-Pierre Routy
Jean-Pierre Routy McGill University Health Centre
Nicolas Chomont
Nicolas Chomont University of Montreal
Elias K. Haddad
Elias K. Haddad Drexel University
Mirko Paiardini
Mirko Paiardini Emory University
Jacob D. Estes
Jacob D. Estes Oregon Health & Science University
Giuseppe Pantaleo
Giuseppe Pantaleo University of Lausanne
Sharon R. Lewin
Sharon R. Lewin University of Melbourne
Genoveffa Franchini
Genoveffa Franchini National Institutes of Health
Richard A. Koup
Richard A. Koup National Institute of Allergy and Infectious Diseases
Joseph M. McCune
Joseph M. McCune University of California, San Francisco

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