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D-Index & Metrics

Molecular Biology

D-Index
43
Citations
6426
World Ranking
2985
National Ranking
1418

Overview

Kristin A. Eckert is affiliated with Pennsylvania State University in the United States. Their scientific work primarily focuses on biochemistry, genetics, and molecular biology, with specific contributions to molecular biology, oncology, cellular and molecular neuroscience, genetics, and ecology.

The research output includes a significant number of publications concentrated in the field of DNA repair mechanisms, RNA and protein synthesis mechanisms, and DNA and nucleic acid chemistry. Additional research areas cover advanced biosensing and bioanalysis techniques, genetic neurodegenerative diseases, cancer-related molecular pathways, and genetics and neurodevelopmental disorders.

Key recent papers reflect these scientific interests, including:

  • Non-B DNA: a major contributor to small- and large-scale variation in nucleotide substitution frequencies across the genome, 2021, Nucleic Acids Research
  • Selection and thermostability suggest G-quadruplexes are novel functional elements of the human genome, 2021, Genome Research
  • Accurate sequencing of DNA motifs able to form alternative (non-B) structures, 2023, Genome Research
  • Variation in G-quadruplex sequence and topology differentially impacts human DNA polymerase fidelity, 2022, DNA repair
  • Impact of G-Quadruplexes and Chronic Inflammation on Genome Instability: Additive Effects during Carcinogenesis, 2021, Genes

Frequent co-authors that have collaborated on multiple works include Kateryna D. Makova, Wilfried M. Guiblet, Francesca Chiaromonte, Yi-Fei Huang, and Matthias H. Weissensteiner.

Their work is published predominantly in venues such as Nucleic Acids Research, Genes, bioRxiv (Cold Spring Harbor Laboratory), Genome Research, and DNA repair. The most common publication venues reflect the focus on molecular biology and genetics-related disciplines.

Best Publications

  • DNA polymerase fidelity and the polymerase chain reaction.

    Kristin A. Eckert;Thomas A. Kunkel

  • High fidelity DNA synthesis by the Thermus aquaticus DNA polymerase.

    Kristin A. Eckert;Thomas A. Kunkel

  • DNA synthesis by Pol η promotes fragile site stability by preventing under-replicated DNA in mitosis

    Valérie Bergoglio;Valérie Bergoglio;Anne Sophie Boyer;Anne Sophie Boyer;Erin Walsh;Valeria Naim

  • Breast cancer metastasis suppressor 1 (BRMS1) forms complexes with retinoblastoma-binding protein 1 (RBP1) and the mSin3 histone deacetylase complex and represses transcription.

    William J. Meehan;Rajeev S. Samant;Rajeev S. Samant;James E. Hopper;Michael J. Carrozza

  • Interplay between DNA repair and inflammation, and the link to cancer

    Dawit Kidane;Wook Jin Chae;Jennifer Czochor;Kristin A Eckert

  • A genome-wide analysis of common fragile sites: What features determine chromosomal instability in the human genome?

    Arkarachai Fungtammasan;Erin Walsh;Francesca Chiaromonte;Kristin A. Eckert

  • Biochemical studies on the reverse transcriptase and RNase H activities from human immunodeficiency virus strains resistant to 3'-azido-3'-deoxythymidine.

    S F Lacey;J E Reardon;E S Furfine;T A Kunkel

  • What is a microsatellite: a computational and experimental definition based upon repeat mutational behavior at A/T and GT/AC repeats

    Yogeshwar D. Kelkar;Noelle Strubczewski;Suzanne E. Hile;Francesca Chiaromonte

  • Every microsatellite is different: Intrinsic DNA features dictate mutagenesis of common microsatellites present in the human genome.

    Kristin A. Eckert;Suzanne E. Hile

  • Defective Mismatch Repair, Microsatellite Mutation Bias, and Variability in Clinical Cancer Phenotypes

    Sandeep N. Shah;Suzanne E. Hile;Kristin A. Eckert

  • DNA polymerases and human diseases.

    Joann B. Sweasy;Julia M. Lauper;Kristin A. Eckert

  • Characterization of human breast epithelial cells by confocal Raman microspectroscopy.

    Chenxu Yu;Erin Gestl;Kristin Eckert;David Allara

  • Factors Affecting Fidelity of DNA Synthesis During PCR Amplification of d(C-A)n•d(G-T)n Microsatellite Repeats

    Jill M. Hite;Kristin A. Eckert;Keith C. Cheng

  • Human PrimPol is a highly error-prone polymerase regulated by single-stranded DNA binding proteins

    Thomas A. Guilliam;Stanislaw K. Jozwiakowski;Aaron Ehlinger;Ryan P. Barnes

  • The proofreading 3'-->5' exonuclease activity of DNA polymerases: a kinetic barrier to translesion DNA synthesis.

    Vineeta Khare;Kristin A Eckert

  • Molecular analysis of mutations induced in human cells by N-ethyl-N-nitrosourea.

    Kristin A. Eckert;Caroline A. Ingle;Donna K. Klinedinst;Norman R. Drinkwater

  • DNA structure and the Werner protein modulate human DNA polymerase delta-dependent replication dynamics within the common fragile site FRA16D

    Sandeep N. Shah;Patricia L. Opresko;Xiao Meng;Marietta Y. W. T. Lee

  • Base Miscoding and Strand Misalignment Errors by Mutator Klenow Polymerases with Amino Acid Substitutions at Tyrosine 766 in the O Helix of the Fingers Subdomain

    Juliette B. Bell;Kristin A. Eckert;Catherine M. Joyce;Thomas A. Kunkel

  • Accurate typing of short tandem repeats from genome-wide sequencing data and its applications

    Arkarachai Fungtammasan;Guruprasad Ananda;Suzanne E. Hile;Marcia Shu Wei Su

  • A matter of life or death: how microsatellites emerge in and vanish from the human genome.

    Yogeshwar D. Kelkar;Kristin A. Eckert;Francesca Chiaromonte;Kateryna D. Makova

Frequent Co-Authors

Kateryna D. Makova
Kateryna D. Makova Pennsylvania State University
Thomas A. Kunkel
Thomas A. Kunkel National Institutes of Health
Patricia L. Opresko
Patricia L. Opresko University of Pittsburgh
Danny R. Welch
Danny R. Welch University of Kansas
Walter J. Chazin
Walter J. Chazin Vanderbilt University
Alfred L. M. Bothwell
Alfred L. M. Bothwell University of Arizona
Rafael Casellas
Rafael Casellas The University of Texas MD Anderson Cancer Center
Katarzyna Bebenek
Katarzyna Bebenek National Institutes of Health
Jonathan Schug
Jonathan Schug University of Pennsylvania
Aidan J. Doherty
Aidan J. Doherty University of Sussex

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