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D-Index & Metrics

Molecular Biology

D-Index
64
Citations
13537
World Ranking
1754
National Ranking
22

Overview

Luis Blanco is affiliated with the Spanish National Research Council in Spain. Their research spans the broader field of Biochemistry, Genetics and Molecular Biology with a focus on Molecular Biology as the main subfield. Additional areas of study include Cancer Research, Epidemiology, Genetics, and Infectious Diseases.

The scientist's work is concentrated on several key topics within molecular biology and genetics. These include:

  • DNA Repair Mechanisms
  • DNA and Nucleic Acid Chemistry
  • CRISPR and Genetic Engineering
  • Genomics and Chromatin Dynamics
  • Epigenetics and DNA Methylation
  • Carcinogens and Genotoxicity Assessment
  • RNA and protein synthesis mechanisms

Blanco has published multiple papers in notable venues, with frequent contributions to UNC Libraries, Nucleic Acids Research, bioRxiv (Cold Spring Harbor Laboratory), International Journal of Molecular Sciences, and The EMBO Journal.

Selected recent publications include:

  • "PrimPol-mediated repriming facilitates replication traverse of DNA interstrand crosslinks," 2021, The EMBO Journal
  • "Identifying the role of PrimPol in TDF-induced toxicity and implications of its loss of function mutation in an HIV+ patient," 2020, Scientific Reports
  • "A unique arginine cluster in PolDIP2 enhances nucleotide binding and DNA synthesis by PrimPol," 2021, Nucleic Acids Research
  • "Human PrimPol Discrimination against Dideoxynucleotides during Primer Synthesis," 2021, Genes
  • "PrimPol primase mediates replication traverse of DNA interstrand crosslinks," 2020, bioRxiv (Cold Spring Harbor Laboratory)

Frequent collaborators in their research include María I. Martínez-Jiménez, Dale A. Ramsden, Juan Méndez, Kazutoshi Kasho, and Gorazd Stojkovič. These collaborations have supported multiple publications, reflecting established working relationships in the field.

Best Publications

  • Highly efficient DNA synthesis by the phage phi 29 DNA polymerase. Symmetrical mode of DNA replication.

    L Blanco;A Bernad;J M Lázaro;G Martín

  • A conserved 3'----5' exonuclease active site in prokaryotic and eukaryotic DNA polymerases.

    Antonio Bernad;Luis Blanco;José M. Lázaro;Gil Martín

  • PrimPol, an Archaic Primase/Polymerase Operating in Human Cells

    Sara García-Gómez;Aurelio Reyes;María I. Martínez-Jiménez;E. Sandra Chocrón

  • Eukaryotic DNA polymerases: proposal for a revised nomenclature.

    Peter M J Burgers;Eugene V. Koonin;Elspeth Bruford;Luis Blanco

  • A gradient of template dependence defines distinct biological roles for family X polymerases in nonhomologous end joining.

    Stephanie A. Nick McElhinny;Jody M. Havener;Miguel Garcia-Diaz;Raquel Juárez

  • DNA polymerase lambda (Pol lambda), a novel eukaryotic DNA polymerase with a potential role in meiosis.

    Miguel Garcı́a-Dı́az;Orlando Domı́nguez;Luis A López-Fernández;Laı́n Teresa de Lera

  • A general structure for DNA-dependent DNA polymerases.

    Luis Blanco;Antonio Bernad;María A. Blasco;Margarita Salas

  • Repriming of DNA synthesis at stalled replication forks by human PrimPol

    Silvana Mourón;Sara Rodriguez-Acebes;María I Martínez-Jiménez;Sara García-Gómez

  • DNA polymerase mu (Pol μ), homologous to TdT, could act as a DNA mutator in eukaryotic cells

    Orlando Domínguez;José F. Ruiz;Teresa Laín de Lera;Miguel García‐Díaz

  • Identification of an intrinsic 5'-deoxyribose-5-phosphate lyase activity in human DNA polymerase lambda: a possible role in base excision repair.

    Miguel Garcı́a-Dı́az;Katarzyna Bebenek;Thomas A. Kunkel;Luis Blanco

  • Implication of DNA Polymerase λ in Alignment-based Gap Filling for Nonhomologous DNA End Joining in Human Nuclear Extracts *

    Jae Wan Lee;Luis Blanco;Tong Zhou;Miguel Garcia-Diaz

  • Characterization and purification of a phage phi 29-encoded DNA polymerase required for the initiation of replication.

    Luis Blanco;Margarita Salas

  • DNA Polymerase λ, a Novel DNA Repair Enzyme in Human Cells

    Miguel Garcı́a-Dı́az;Katarzyna Bebenek;Rosario Sabariegos;Orlando Domı́nguez

  • Structures of phi29 DNA polymerase complexed with substrate: the mechanism of translocation in B-family polymerases

    Andrea J Berman;Satwik Kamtekar;Jessica L Goodman;José M Lázaro

  • Insights into strand displacement and processivity from the crystal structure of the protein-primed DNA polymerase of bacteriophage phi29.

    Satwik Kamtekar;Andrea J. Berman;Jimin Wang;José M. Lázaro

  • Structural and functional relationships between prokaryotic and eukaryotic DNA polymerases.

    A Bernad;A Zaballos;M Salas;L Blanco

  • Relating Structure to Function in 29 DNA Polymerase

    Luis Blanco;Margarita Salas

  • The bacteriophage phi 29 DNA polymerase, a proofreading enzyme.

    C Garmendia;A Bernad;J A Esteban;L Blanco

  • A Structural Solution for the DNA Polymerase λ-Dependent Repair of DNA Gaps with Minimal Homology

    Miguel Garcia-Diaz;Katarzyna Bebenek;Joseph M Krahn;Luis Blanco

  • Site-directed mutagenesis at the Exo III motif of phi 29 DNA polymerase; overlapping structural domains for the 3'-5' exonuclease and strand-displacement activities.

    M.S. Soengas;J.A. Esteban;J.M. Lázaro;A. Bernad

Frequent Co-Authors

Margarita Salas
Margarita Salas Spanish National Research Council
Antonio Bernad
Antonio Bernad Spanish National Research Council
Maria A. Blasco
Maria A. Blasco Spanish National Cancer Research Centre
Katarzyna Bebenek
Katarzyna Bebenek National Institutes of Health
Thomas A. Kunkel
Thomas A. Kunkel National Institutes of Health
Thomas A. Steitz
Thomas A. Steitz Yale University
Paula B. Andrade
Paula B. Andrade University of Porto
Juan Antonio García
Juan Antonio García Spanish National Research Council
Dale A. Ramsden
Dale A. Ramsden University of North Carolina at Chapel Hill
Aidan J. Doherty
Aidan J. Doherty University of Sussex

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