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Molecular Biology

D-Index
59
Citations
10523
World Ranking
2033
National Ranking
163

Overview

Kengo Sakaguchi is affiliated with Tokyo University of Science in Japan. Their research spans multiple fields primarily within Biochemistry, Genetics and Molecular Biology, and Medicine, with a specific focus on Molecular Biology, Oncology, Cancer Research, Pulmonary and Respiratory Medicine, and Materials Chemistry.

The main topics addressed in their work include Cancer, Hypoxia, and Metabolism; Monoclonal and Polyclonal Antibodies Research; Advanced Biosensing Techniques and Applications; Bacteriophages and microbial interactions; Lung Cancer Research Studies; Pancreatic and Hepatic Oncology Research; and Neuroendocrine Tumor Research Advances.

The scientist has contributed to several recent papers, demonstrating a focus on cancer therapeutics, radioimmunotherapy, and biochemical mechanisms under hypoxic conditions:

  • Phage display technology for target determination of small-molecule therapeutics: an update, 2020, Expert Opinion on Drug Discovery
  • The natural sulfoglycolipid derivative SQAP improves the therapeutic efficacy of tissue factor-targeted radioimmunotherapy in the stroma-rich pancreatic cancer model BxPC-3, 2021, Translational Oncology
  • SQAP, an acyl sulfoquinovosyl derivative, suppresses expression of histone deacetylase and induces cell death of cancer cells under hypoxic conditions, 2021, Bioscience Biotechnology and Biochemistry
  • Epo-C12 inhibits peroxiredoxin 1 peroxidase activity, 2021, Bioorganic & Medicinal Chemistry
  • Anticancer agent α-sulfoquinovosyl-acylpropanediol enhances the radiosensitivity of human malignant mesothelioma in nude mouse models, 2021, Journal of Radiation Research

Sakaguchi frequently collaborates with other researchers, with notable co-authors including Fumio Sugawara, Yoichi Takakusagi, Kouji Kuramochi, Masahiko Oshige, and Koki Kano.

Their work has been published across a range of scientific venues, indicating a multidisciplinary approach:

  • Expert Opinion on Drug Discovery
  • Translational Oncology
  • Bioscience Biotechnology and Biochemistry
  • Journal of Radiation Research
  • Bioorganic & Medicinal Chemistry

Best Publications

  • A method for the molecular imprinting of hemoglobin on silica surfaces using silanes

    Toru Shiomi;Masayoshi Matsui;Fujio Mizukami;Kengo Sakaguchi

  • The inhibitory action of fatty acids on DNA polymerase β

    Yoshiyuki Mizushina;Shonen Yoshida;Akio Matsukage;Kengo Sakaguchi

  • Sulfoquinovosyldiacylglycerol, KM043, a New Potent Inhibitor of Eukaryotic DNA Polymerases and HIV-Reverse Transcriptase Type 1 from a Marine Red Alga, Gigartina tenella.

    Keisuke Ohta;Yoshiyuki Mizushima;Noriko Hirata;Masaharu Takemura

  • Fatty acids selectively inhibit eukaryotic DNA polymerase activities in vitro.

    Yoshiyuki Mizushina;Nobukazu Tanaka;Hisaaki Yagi;Takayoshi Kurosawa

  • DNA repair in plants.

    Seisuke Kimura;Kengo Sakaguchi

  • Inhibition of human telomerase by rubromycins: implication of spiroketal system of the compounds as an active moiety.

    Takamasa Ueno;Hirotada Takahashi;Masako Oda;Makiko Mizunuma

  • DNA damage response in plants: conserved and variable response compared to animals.

    Kaoru Okamoto Yoshiyama;Kengo Sakaguchi;Seisuke Kimura

  • A Mushroom Fruiting Body-Inducing Substance Inhibits Activities of Replicative DNA Polymerases

    Yoshiyuki Mizushina;Linda Hanashima;Toyofumi Yamaguchi;Masaharu Takemura

  • Studies on inhibitors of mammalian DNA polymerase α and β: Sulfolipids from a pteridophyte, Athyrium niponicum

    Yoshiyuki Mizushina;Itiro Watanabe;Keisuke Ohta;Masaharu Takemura

  • Lucidenic acid O and lactone, new terpene inhibitors of eukaryotic DNA polymerases from a basidiomycete, Ganoderma lucidum.

    Yoshiyuki Mizushina;Naoko Takahashi;Linda Hanashima;Hiroyuki Koshino

  • Selective adsorption of biopolymers on zeolites.

    Masayoshi Matsui;Yoshimichi Kiyozumi;Taichi Yamamoto;Yoshiyuki Mizushina

  • Plant DNA polymerase λ, a DNA repair enzyme that functions in plant meristematic and meiotic tissues

    Yukinobu Uchiyama;Seisuke Kimura;Taichi Yamamoto;Toyotaka Ishibashi

  • Encapsulation of hemoglobin in mesoporous silica (FSM)-enhanced thermal stability and resistance to denaturants.

    Yoko Urabe;Yoko Urabe;Toru Shiomi;Toru Shiomi;Tetsuji Itoh;Akiko Kawai

  • Action of Bredinin on Mammalian Cells

    Kengo Sakaguchi;Masatoshi Tsujino;Munetoshi Yoshizawa;Kimio Mizuno

  • Novel triterpenoids inhibit both DNA polymerase and DNA topoisomerase.

    Yoshiyuki Mizushina;Akira Iida;Keisuke Ohta;Fumio Sugawara

  • The DNA Replication-related Element (DRE)/DRE-binding Factor System Is a Transcriptional Regulator of the Drosophila E2FGene

    Tomoyuki Sawado;Fumiko Hirose;Yasuhiko Takahashi;Takayo Sasaki

  • Knockdown of LIM15/DMC1 in the mushroom Coprinus cinereus by double-stranded RNA-mediated gene silencing.

    Satoshi H. Namekawa;Kazuki Iwabata;Hiroko Sugawara;Fumika N. Hamada

  • DNA repair in higher plants; photoreactivation is the major DNA repair pathway in non‐proliferating cells while excision repair (nucleotide excision repair and base excision repair) is active in proliferating cells

    Seisuke Kimura;Yasue Tahira;Toyotaka Ishibashi;Yoko Mori

  • Chromatin-Associated DNA Polymerase Activity in Meiotic Cells of Lily and Mouse;its Stimulation by Meiotic Helix-Destabilizing Protein

    Kengo Sakaguchi;Yasuo Hotta;Herbert Stern

  • Transcriptional Regulation of the Drosophila CycA Gene by the DNA Replication-Related Element (DRE) and DRE Binding Factor (DREF)

    Katsuhito Ohno;Fumiko Hirose;Kengo Sakaguchi;Yasuyoshi Nishida

Frequent Co-Authors

Yoshiyuki Mizushina
Yoshiyuki Mizushina Shinshu University
Hiromi Yoshida
Hiromi Yoshida Kobe Gakuin University
Fujio Mizukami
Fujio Mizukami National Institute of Advanced Industrial Science and Technology
Noriyuki Sato
Noriyuki Sato Sapporo Medical University
Akio Matsukage
Akio Matsukage Hokkaido University
Shonen Yoshida
Shonen Yoshida Nagoya University
Masamitsu Yamaguchi
Masamitsu Yamaguchi Kyoto Institute of Technology
Masahiko Abe
Masahiko Abe Tokyo University of Science
Hideki Sakai
Hideki Sakai Tokyo University of Science
Hiroyuki Koshino
Hiroyuki Koshino Tokyo University of Agriculture

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