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Genetics

D-Index
57
Citations
12718
World Ranking
3405
National Ranking
1471

Overview

Dale A. Ramsden is affiliated with the University of North Carolina at Chapel Hill in the United States. Their research primarily focuses on topics within Biochemistry, Genetics, and Molecular Biology, with a strong specialization in Molecular Biology.

The scientist's work covers a range of interconnected subfields and topics such as:

  • Molecular Biology
  • Oncology
  • Cell Biology
  • Plant Science
  • Genetics

The main research interests of Dale A. Ramsden encompass:

  • DNA Repair Mechanisms
  • CRISPR and Genetic Engineering
  • DNA and Nucleic Acid Chemistry
  • Genomics and Chromatin Dynamics
  • Microtubule and mitosis dynamics
  • Cancer therapeutics and mechanisms
  • Mitochondrial Function and Pathology

Their publication record includes papers in notable scientific venues, with frequent contributions to:

  • UNC Libraries
  • Nature Communications
  • bioRxiv (Cold Spring Harbor Laboratory)
  • Nature Reviews Molecular Cell Biology
  • Nature

Recent papers authored or co-authored by Dale A. Ramsden illustrate their involvement in the study of DNA repair and mechanisms related to cancer biology. These include:

  • The molecular basis and disease relevance of non-homologous DNA end joining (2020, Nature Reviews Molecular Cell Biology)
  • Mechanism, cellular functions and cancer roles of polymerase-theta-mediated DNA end joining (2021, Nature Reviews Molecular Cell Biology)
  • Mechanistic basis for microhomology identification and genome scarring by polymerase theta (2020, Proceedings of the National Academy of Sciences)
  • Radiation-related genomic profile of papillary thyroid carcinoma after the Chernobyl accident (2021, Science)
  • Retrotransposons hijack alt-EJ for DNA replication and eccDNA biogenesis (2023, Nature)

Frequent co-authors in their publications include:

  • Juan Carvajal-Garcia
  • Gaorav P. Gupta
  • Thomas A. Kunkel
  • Wanjuan Feng
  • Adam J. Luthman

Best Publications

  • Cleavage at a V(D)J recombination signal requires only RAG1 and RAG2 proteins and occurs in two steps

    J.Fraser McBlane;Dik C. van Gent;Dale A. Ramsden;Charles Romeo

  • Ku Recruits the XRCC4-Ligase IV Complex to DNA Ends

    Stephanie A. Nick McElhinny;Carey M. Snowden;Joseph McCarville;Dale A. Ramsden

  • Autophosphorylation of the catalytic subunit of the DNA-dependent protein kinase is required for efficient end processing during DNA double-strand break repair.

    Qi Ding;Yeturu V. R. Reddy;Wei Wang;Timothy Woods

  • Ku complex interacts with and stimulates the Werner protein

    Marcus P. Cooper;Amrita Machwe;David K. Orren;Robert M. Brosh

  • Ku protein stimulates DNA end joining by mammalian DNA ligases: a direct role for Ku in repair of DNA double‐strand breaks

    Dale A. Ramsden;Martin Gellert

  • Association of DNA Polymerase μ (pol μ) with Ku and Ligase IV: Role for pol μ in End-Joining Double-Strand Break Repair

    Kiran N. Mahajan;Stephanie A. Nick McElhinny;Beverly S. Mitchell;Dale A. Ramsden

  • Initiation of V(D)J recombination in a cell-free system

    Dik C van Gent;J Fraser McBlane;Dale A Ramsden;Moshe J Sadofsky

  • The RAG1 and RAG2 Proteins Establish the 12/23 Rule in V(D)J Recombination

    Dik C van Gent;Dale A Ramsden;Martin Gellert

  • A gradient of template dependence defines distinct biological roles for family X polymerases in nonhomologous end joining.

    Stephanie A. Nick McElhinny;Jody M. Havener;Miguel Garcia-Diaz;Raquel Juárez

  • Inflammasome-independent role of AIM2 in suppressing colon tumorigenesis via DNA-PK and Akt

    Justin E. Wilson;Alex S. Petrucelli;Liang Chen;A. Alicia Koblansky

  • The molecular basis and disease relevance of non-homologous DNA end joining

    Bailin Zhao;Eli Rothenberg;Dale A. Ramsden;Michael R. Lieber

  • The DNA-dependent protein kinase: the director at the end.

    Katheryn Meek;Shikha Gupta;Dale A. Ramsden;Susan P. Lees-Miller

  • Mechanism of suppression of chromosomal instability by DNA polymerase POLQ

    Matthew J. Yousefzadeh;David W. Wyatt;Kei ichi Takata;Yunxiang Mu

  • Essential Roles for Polymerase θ-Mediated End Joining in the Repair of Chromosome Breaks

    David W. Wyatt;Wanjuan Feng;Michael P. Conlin;Matthew J. Yousefzadeh

  • Conservation of sequence in recombination signal sequence spacers

    Dale A. Ramsden;Kristin Baetz;Gillian E. Wu

  • Ku is a 5′-dRP/AP lyase that excises nucleotide damage near broken ends

    Steven A. Roberts;Natasha Strande;Martin D. Burkhalter;Christina Strom

  • Distinct DNA sequence and structure requirements for the two steps of V(D)J recombination signal cleavage

    D. A. Ramsden;J. F. McBlane;D. C. van Gent;M. Gellert

  • Polymerase mu is a DNA-directed DNA/RNA polymerase.

    Stephanie A. Nick McElhinny;Dale A. Ramsden

  • Formation and resolution of double-strand break intermediates in V(D)J rearrangement.

    Dale A. Ramsden;Martin Gellert

  • Cell-free V ( D ) J recombination

    Dale A. Ramsden;Dale A. Ramsden;Tanya T. Paull;Tanya T. Paull;Martin Gellert

Frequent Co-Authors

Christopher J. Paige
Christopher J. Paige Princess Margaret Cancer Centre
Thomas A. Kunkel
Thomas A. Kunkel National Institutes of Health
Katarzyna Bebenek
Katarzyna Bebenek National Institutes of Health
Lars C. Pedersen
Lars C. Pedersen National Institutes of Health
Richard D. Wood
Richard D. Wood The University of Texas MD Anderson Cancer Center
Susan P. Lees-Miller
Susan P. Lees-Miller University of Calgary
Luis Blanco
Luis Blanco Spanish National Research Council
Michael R. Lieber
Michael R. Lieber University of Southern California
Joel S. Parker
Joel S. Parker University of North Carolina at Chapel Hill
Piotr A. Mieczkowski
Piotr A. Mieczkowski University of North Carolina at Chapel Hill

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